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Year Number of Results
2002 1
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2004 3
2005 5
2006 9
2007 8
2008 6
2009 6
2010 10
2011 20
2012 19
2013 20
2014 19
2015 20
2016 16
2017 15
2018 21
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290 results

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Page 1
The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria.
Woodland JG, Coertzen D, Wicht KJ, Hidalgo VF, Pasaje CFA, Godoy LC, Qahash T, Mmonwa MM, Dziwornu GA, Wambua L, Harries S, Korkor CM, Njoroge M, Krugmann L, Taylor D, Leshabane M, Langeveld H, Rabie T, Reader J, van der Watt M, Venter N, Erlank E, Aswat AS, Koekemoer LL, Yeo T, Jeon JH, Fidock DA, Gamo FJ, Wittlin S, Niles JC, Llinas M, Coulson LB, Birkholtz LM, Chibale K. Woodland JG, et al. Among authors: chibale k. Angew Chem Int Ed Engl. 2025 Jul 7;64(28):e202425206. doi: 10.1002/anie.202425206. Epub 2025 May 15. Angew Chem Int Ed Engl. 2025. PMID: 40317875 Free PMC article.
Medicinal Chemistry Progression of Sapanisertib, the Anticancer and Dual Plasmodium Phosphatidylinositol 4-Kinase Beta and cGMP-Dependent Protein Kinase Inhibitor, for Malaria.
Gachuhi S, Kamunya S, Fienberg S, Wambua L, Salomane N, Mayoka G, Taylor D, Coertzen D, van der Watt M, Reader J, Birkholtz LM, Wittlin S, Krugmann L, Coulson LB, Chibale K. Gachuhi S, et al. Among authors: chibale k. J Med Chem. 2025 Jun 12;68(11):10757-10770. doi: 10.1021/acs.jmedchem.4c02799. Epub 2025 May 16. J Med Chem. 2025. PMID: 40377111 Free PMC article.
Cell-Based Progression of Spiroindoline Phenotypic Hits Leads to the Identification of Compounds with Diverging Parasitological Profiles against the Human Malaria Parasite Plasmodium falciparum.
Dam J, Boyle GA, Horatscheck A, Woodland JG, Le Manach C, Kaur G, Taylor D, Krugmann L, Njoroge M, Lawrence N, Brunschwig C, Zdorichenko V, Cox B, Wittlin S, von Geldern TW, Smith D, Duffy J, Basarab GS, Chibale K. Dam J, et al. Among authors: chibale k. J Med Chem. 2025 May 22;68(10):10156-10172. doi: 10.1021/acs.jmedchem.5c00302. Epub 2025 May 12. J Med Chem. 2025. PMID: 40353796 Free PMC article.
Synthesis and SAR Studies of Acyl-Thiourea Platinum(II) Complexes Yield Analogs with Dual-Stage Antiplasmodium Activity.
Ishmail FZ, Coertzen D, Tshabalala S, Leshabane M, da Rocha S, Njoroge M, Gibhard L, Birkholtz LM, Woodland JG, Egan TJ, Wicht KJ, Chibale K. Ishmail FZ, et al. Among authors: chibale k. ACS Med Chem Lett. 2025 Feb 17;16(3):428-435. doi: 10.1021/acsmedchemlett.4c00545. eCollection 2025 Mar 13. ACS Med Chem Lett. 2025. PMID: 40104806 Free PMC article.
Discovery of Non-Covalent Inhibitors for SARS-CoV-2 PLpro: Integrating Virtual Screening, Synthesis, and Experimental Validation.
Sousa BKP, Mottin M, Seanego D, Jurisch CD, Rodrigues BSA, da Silva VLS, Andrade MA, Morais GS, Boerin DF, Froes TQ, Motta FN, Nonato MC, Bastos IDM, Chibale K, Gessner RK, Andrade CH. Sousa BKP, et al. Among authors: chibale k. ACS Med Chem Lett. 2024 Dec 2;15(12):2140-2149. doi: 10.1021/acsmedchemlett.4c00420. eCollection 2024 Dec 12. ACS Med Chem Lett. 2024. PMID: 39691531 Free PMC article.
Author Correction: Antimalarial drug discovery: progress and approaches.
Siqueira-Neto JL, Wicht KJ, Chibale K, Burrows JN, Fidock DA, Winzeler EA. Siqueira-Neto JL, et al. Among authors: chibale k. Nat Rev Drug Discov. 2024 Nov;23(11):880. doi: 10.1038/s41573-024-01045-9. Nat Rev Drug Discov. 2024. PMID: 39271962 No abstract available.
Dose-fractionation studies of a Plasmodium phosphatidylinositol 4-kinase inhibitor in a humanized mouse model of malaria.
Gibhard L, Njoroge M, Mulubwa M, Lawrence N, Smith D, Duffy J, Le Manach C, Brunschwig C, Taylor D, van der Westhuyzen R, Street LJ, Basarab GS, Chibale K. Gibhard L, et al. Among authors: chibale k. Antimicrob Agents Chemother. 2024 Oct 8;68(10):e0084224. doi: 10.1128/aac.00842-24. Epub 2024 Aug 28. Antimicrob Agents Chemother. 2024. PMID: 39194209 Free PMC article.
The Tuberculosis Drug Candidate SQ109 and Its Analogs Have Multistage Activity against Plasmodium falciparum.
Watson SJ, van der Watt ME, Theron A, Reader J, Tshabalala S, Erlank E, Koekemoer LL, Naude M, Stampolaki M, Adewole F, Sadowska K, Pérez-Lozano P, Turcu AL, Vázquez S, Ko J, Mazurek B, Singh D, Malwal SR, Njoroge M, Chibale K, Onajole OK, Kolocouris A, Oldfield E, Birkholtz LM. Watson SJ, et al. Among authors: chibale k. ACS Infect Dis. 2024 Sep 13;10(9):3358-3367. doi: 10.1021/acsinfecdis.4c00461. Epub 2024 Aug 14. ACS Infect Dis. 2024. PMID: 39143042 Free PMC article.
2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy.
Dziwornu GA, Seanego D, Fienberg S, Clements M, Ferreira J, Sypu VS, Samanta S, Bhana AD, Korkor CM, Garnie LF, Teixeira N, Wicht KJ, Taylor D, Olckers R, Njoroge M, Gibhard L, Salomane N, Wittlin S, Mahato R, Chakraborty A, Sevilleno N, Coyle R, Lee MCS, Godoy LC, Pasaje CF, Niles JC, Reader J, van der Watt M, Birkholtz LM, Bolscher JM, de Bruijni MHC, Coulson LB, Basarab GS, Ghorpade SR, Chibale K. Dziwornu GA, et al. Among authors: chibale k. J Med Chem. 2024 Jul 11;67(13):11401-11420. doi: 10.1021/acs.jmedchem.4c01154. Epub 2024 Jun 25. J Med Chem. 2024. PMID: 38918002 Free PMC article.
Characterization of antimalarial activity of artemisinin-based hybrid drugs.
Quadros HC, Herrmann L, Manaranche J, Paloque L, Borges-Silva MC, Dziwornu GA, D'Alessandro S, Chibale K, Basilico N, Benoit-Vical F, Tsogoeva SB, Moreira DRM. Quadros HC, et al. Among authors: chibale k. Antimicrob Agents Chemother. 2024 Jul 9;68(7):e0014324. doi: 10.1128/aac.00143-24. Epub 2024 Jun 20. Antimicrob Agents Chemother. 2024. PMID: 38899927 Free PMC article.
Forging a Future Free from Neglected Tropical Diseases.
da Silva Emery F, Chibale K. da Silva Emery F, et al. Among authors: chibale k. ACS Med Chem Lett. 2024 Feb 26;15(3):314-315. doi: 10.1021/acsmedchemlett.4c00060. eCollection 2024 Mar 14. ACS Med Chem Lett. 2024. PMID: 38505853 Free PMC article. No abstract available.
Drug discovery in Africa tackles zoonotic and related infections.
Hikaambo CN, Shakela N, Woodland JG, Wicht KJ, Chibale K. Hikaambo CN, et al. Among authors: chibale k. Sci Transl Med. 2023 Oct 18;15(718):eadj0035. doi: 10.1126/scitranslmed.adj0035. Epub 2023 Oct 18. Sci Transl Med. 2023. PMID: 37851825 Review.
Antimalarial drug discovery: progress and approaches.
Siqueira-Neto JL, Wicht KJ, Chibale K, Burrows JN, Fidock DA, Winzeler EA. Siqueira-Neto JL, et al. Among authors: chibale k. Nat Rev Drug Discov. 2023 Oct;22(10):807-826. doi: 10.1038/s41573-023-00772-9. Epub 2023 Aug 31. Nat Rev Drug Discov. 2023. PMID: 37652975 Free PMC article. Review.
Including African data in drug discovery and development.
Veale CGL, Edkins AL, Winks S, Njoroge M, Chibale K. Veale CGL, et al. Among authors: chibale k. Nat Rev Drug Discov. 2023 Jul;22(7):521-522. doi: 10.1038/d41573-023-00088-8. Nat Rev Drug Discov. 2023. PMID: 37264173 No abstract available.
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model.
Mambwe D, Korkor CM, Mabhula A, Ngqumba Z, Cloete C, Kumar M, Barros PL, Leshabane M, Coertzen D, Taylor D, Gibhard L, Njoroge M, Lawrence N, Reader J, Moreira DR, Birkholtz LM, Wittlin S, Egan TJ, Chibale K. Mambwe D, et al. Among authors: chibale k. J Med Chem. 2022 Dec 22;65(24):16695-16715. doi: 10.1021/acs.jmedchem.2c01516. Epub 2022 Dec 12. J Med Chem. 2022. PMID: 36507890
1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis.
Singh V, Grzegorzewicz AE, Fienberg S, Müller R, Khonde LP, Sanz O, Alfonso S, Urones B, Drewes G, Bantscheff M, Ghidelli-Disse S, Ioerger TR, Angala B, Liu J, Lee RE, Sacchettini JC, Krieger IV, Jackson M, Chibale K, Ghorpade SR. Singh V, et al. Among authors: chibale k. ACS Infect Dis. 2022 Nov 11;8(11):2315-2326. doi: 10.1021/acsinfecdis.2c00392. Epub 2022 Nov 3. ACS Infect Dis. 2022. PMID: 36325756 Free PMC article.
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages.
Arendse LB, Murithi JM, Qahash T, Pasaje CFA, Godoy LC, Dey S, Gibhard L, Ghidelli-Disse S, Drewes G, Bantscheff M, Lafuente-Monasterio MJ, Fienberg S, Wambua L, Gachuhi S, Coertzen D, van der Watt M, Reader J, Aswat AS, Erlank E, Venter N, Mittal N, Luth MR, Ottilie S, Winzeler EA, Koekemoer LL, Birkholtz LM, Niles JC, Llinás M, Fidock DA, Chibale K. Arendse LB, et al. Among authors: chibale k. Sci Transl Med. 2022 Oct 19;14(667):eabo7219. doi: 10.1126/scitranslmed.abo7219. Epub 2022 Oct 19. Sci Transl Med. 2022. PMID: 36260689 Free PMC article.
Drug discovery research in Ghana, challenges, current efforts, and the way forward.
Amewu RK, Amoateng P, Arthur PK, Asare P, Asiamah I, Boamah D, Darko Otchere I, Dzidzor Amengor C, Ekuadzi E, Chibale K, Farrell SJ, Appiah-Oppong R, Osei-Safo D, David Read K, Hugh Gilbert I, Yeboah-Manu D. Amewu RK, et al. Among authors: chibale k. PLoS Negl Trop Dis. 2022 Sep 15;16(9):e0010645. doi: 10.1371/journal.pntd.0010645. eCollection 2022 Sep. PLoS Negl Trop Dis. 2022. PMID: 36107859 Free PMC article. Review.
Total Synthesis of the Antimycobacterial Natural Product Chlorflavonin and Analogs via a Late-Stage Ruthenium(II)-Catalyzed ortho-C(sp2)-H-Hydroxylation.
Berger A, Knak T, Kiffe-Delf AL, Mudrovcic K, Singh V, Njoroge M, Burckhardt BB, Gopalswamy M, Lungerich B, Ackermann L, Gohlke H, Chibale K, Kalscheuer R, Kurz T. Berger A, et al. Among authors: chibale k. Pharmaceuticals (Basel). 2022 Aug 10;15(8):984. doi: 10.3390/ph15080984. Pharmaceuticals (Basel). 2022. PMID: 36015133 Free PMC article.
Fostering drug discovery and development in Africa.
Winks S, Woodland JG, Pillai G', Chibale K. Winks S, et al. Among authors: chibale k. Nat Med. 2022 Aug;28(8):1523-1526. doi: 10.1038/s41591-022-01885-1. Nat Med. 2022. PMID: 35840729 No abstract available.
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.
Murithi JM, Deni I, Pasaje CFA, Okombo J, Bridgford JL, Gnädig NF, Edwards RL, Yeo T, Mok S, Burkhard AY, Coburn-Flynn O, Istvan ES, Sakata-Kato T, Gomez-Lorenzo MG, Cowell AN, Wicht KJ, Le Manach C, Kalantarov GF, Dey S, Duffey M, Laleu B, Lukens AK, Ottilie S, Vanaerschot M, Trakht IN, Gamo FJ, Wirth DF, Goldberg DE, Odom John AR, Chibale K, Winzeler EA, Niles JC, Fidock DA. Murithi JM, et al. Among authors: chibale k. Cell Chem Biol. 2022 May 19;29(5):824-839.e6. doi: 10.1016/j.chembiol.2021.06.006. Epub 2021 Jul 6. Cell Chem Biol. 2022. PMID: 34233174 Free PMC article.
Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity.
Govender P, Müller R, Singh K, Reddy V, Eyermann CJ, Fienberg S, Ghorpade SR, Koekemoer L, Myrick A, Schnappinger D, Engelhart C, Meshanni J, Byl JAW, Osheroff N, Singh V, Chibale K, Basarab GS. Govender P, et al. Among authors: chibale k. J Med Chem. 2022 May 12;65(9):6903-6925. doi: 10.1021/acs.jmedchem.2c00266. Epub 2022 May 2. J Med Chem. 2022. PMID: 35500229 Free PMC article.
290 results