kenneth matreyek - Search Results

Year	Number of Results
2006	1
2007	1
2009	1
2010	1
2011	2
2012	2
2013	3
2014	2
2017	1
2018	2
2019	1
2020	7
2021	4
2022	4
2023	4
2024	5
2025	0

1

High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology.

Muhammad A, Calandranis ME, Li B, Yang T, Blackwell DJ, Harvey ML, Smith JE, Daniel ZA, Chew AE, Capra JA, Matreyek KA, Fowler DM, Roden DM, Glazer AM. Muhammad A, et al. Among authors: matreyek ka. Genome Med. 2024 May 30;16(1):73. doi: 10.1186/s13073-024-01340-5. Genome Med. 2024. PMID: 38816749 Free PMC article.

2

Pseudotyped virus infection of multiplexed ACE2 libraries reveals SARS-CoV-2 variant shifts in receptor usage.

Shukla N, Roelle SM, Snell JC, DelSignore O, Bruchez AM, Matreyek KA. Shukla N, et al. Among authors: matreyek ka. PLoS Pathog. 2024 May 20;20(5):e1012044. doi: 10.1371/journal.ppat.1012044. eCollection 2024 May. PLoS Pathog. 2024. PMID: 38768238 Free PMC article.

3

Evidence of antigenic drift in the fusion machinery core of SARS-CoV-2 spike.

Tan TJC, Verma AK, Odle A, Lei R, Meyerholz DK, Matreyek KA, Perlman S, Wong LR, Wu NC. Tan TJC, et al. Among authors: matreyek ka. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2317222121. doi: 10.1073/pnas.2317222121. Epub 2024 Apr 1. Proc Natl Acad Sci U S A. 2024. PMID: 38557175 Free PMC article.

4

Multiplex Functional Characterization of Protein Variant Libraries in Mammalian Cells with Single-Copy Genomic Integration and High-Throughput DNA Sequencing.

Kamath ND, Matreyek KA. Kamath ND, et al. Among authors: matreyek ka. Methods Mol Biol. 2024;2774:135-152. doi: 10.1007/978-1-0716-3718-0_10. Methods Mol Biol. 2024. PMID: 38441763

5

CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods.

Critical Assessment of Genome Interpretation Consortium. Critical Assessment of Genome Interpretation Consortium. Genome Biol. 2024 Feb 22;25(1):53. doi: 10.1186/s13059-023-03113-6. Genome Biol. 2024. PMID: 38389099 Free PMC article.

6

Optogenetic Microwell Array Screening System: A High-Throughput Engineering Platform for Genetically Encoded Fluorescent Indicators.

Rappleye M, Wait SJ, Lee JD, Siebart JC, Torp L, Smith N, Muster J, Matreyek KA, Fowler DM, Berndt A. Rappleye M, et al. Among authors: matreyek ka. ACS Sens. 2023 Nov 24;8(11):4233-4244. doi: 10.1021/acssensors.3c01573. Epub 2023 Nov 13. ACS Sens. 2023. PMID: 37956352 Free PMC article.

7

Mammalian Genomic Manipulation with Orthogonal Bxb1 DNA Recombinase Sites for the Functional Characterization of Protein Variants.

Roelle SM, Kamath ND, Matreyek KA. Roelle SM, et al. Among authors: matreyek ka. ACS Synth Biol. 2023 Nov 17;12(11):3352-3365. doi: 10.1021/acssynbio.3c00355. Epub 2023 Nov 3. ACS Synth Biol. 2023. PMID: 37922210 Free PMC article.

8

Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome K_ATP Channel Mutations in Intact Cells.

Gao J, McClenaghan C, Matreyek KA, Grange DK, Nichols CG. Gao J, et al. Among authors: matreyek ka. J Pharmacol Exp Ther. 2023 Sep;386(3):298-309. doi: 10.1124/jpet.123.001659. Epub 2023 Aug 1. J Pharmacol Exp Ther. 2023. PMID: 37527933 Free PMC article.

9

High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike.

Tan TJC, Mou Z, Lei R, Ouyang WO, Yuan M, Song G, Andrabi R, Wilson IA, Kieffer C, Dai X, Matreyek KA, Wu NC. Tan TJC, et al. Among authors: matreyek ka. Nat Commun. 2023 Apr 10;14(1):2003. doi: 10.1038/s41467-023-37786-1. Nat Commun. 2023. PMID: 37037866 Free PMC article.

10

Probing the biophysical constraints of SARS-CoV-2 spike N-terminal domain using deep mutational scanning.

Ouyang WO, Tan TJC, Lei R, Song G, Kieffer C, Andrabi R, Matreyek KA, Wu NC. Ouyang WO, et al. Among authors: matreyek ka. Sci Adv. 2022 Nov 25;8(47):eadd7221. doi: 10.1126/sciadv.add7221. Epub 2022 Nov 23. Sci Adv. 2022. PMID: 36417523 Free PMC article.

11

Receptor-Binding Domain (RBD) Antibodies Contribute More to SARS-CoV-2 Neutralization When Target Cells Express High Levels of ACE2.

Farrell AG, Dadonaite B, Greaney AJ, Eguia R, Loes AN, Franko NM, Logue J, Carreño JM, Abbad A, Chu HY, Matreyek KA, Bloom JD. Farrell AG, et al. Among authors: matreyek ka. Viruses. 2022 Sep 16;14(9):2061. doi: 10.3390/v14092061. Viruses. 2022. PMID: 36146867 Free PMC article.

12

Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domains.

Roelle SM, Shukla N, Pham AT, Bruchez AM, Matreyek KA. Roelle SM, et al. Among authors: matreyek ka. PLoS Biol. 2022 Jul 27;20(7):e3001738. doi: 10.1371/journal.pbio.3001738. eCollection 2022 Jul. PLoS Biol. 2022. PMID: 35895696 Free PMC article.

13

Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution.

Starr TN, Greaney AJ, Hannon WW, Loes AN, Hauser K, Dillen JR, Ferri E, Farrell AG, Dadonaite B, McCallum M, Matreyek KA, Corti D, Veesler D, Snell G, Bloom JD. Starr TN, et al. Among authors: matreyek ka. Science. 2022 Jul 22;377(6604):420-424. doi: 10.1126/science.abo7896. Epub 2022 Jun 28. Science. 2022. PMID: 35762884 Free PMC article.

14

Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling.

Coyote-Maestas W, Nedrud D, Suma A, He Y, Matreyek KA, Fowler DM, Carnevale V, Myers CL, Schmidt D. Coyote-Maestas W, et al. Among authors: matreyek ka. Nat Commun. 2021 Dec 8;12(1):7114. doi: 10.1038/s41467-021-27342-0. Nat Commun. 2021. PMID: 34880224 Free PMC article.

15

Integrating thousands of PTEN variant activity and abundance measurements reveals variant subgroups and new dominant negatives in cancers.

Matreyek KA, Stephany JJ, Ahler E, Fowler DM. Matreyek KA, et al. Genome Med. 2021 Oct 14;13(1):165. doi: 10.1186/s13073-021-00984-x. Genome Med. 2021. PMID: 34649609 Free PMC article.

16

Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection.

Shukla N, Roelle SM, Suzart VG, Bruchez AM, Matreyek KA. Shukla N, et al. Among authors: matreyek ka. PLoS Pathog. 2021 Jul 16;17(7):e1009715. doi: 10.1371/journal.ppat.1009715. eCollection 2021 Jul. PLoS Pathog. 2021. PMID: 34270613 Free PMC article.

17

Extracellular vesicles carry SARS-CoV-2 spike protein and serve as decoys for neutralizing antibodies.

Troyer Z, Alhusaini N, Tabler CO, Sweet T, de Carvalho KIL, Schlatzer DM, Carias L, King CL, Matreyek K, Tilton JC. Troyer Z, et al. Among authors: matreyek k. J Extracell Vesicles. 2021 Jun;10(8):e12112. doi: 10.1002/jev2.12112. Epub 2021 Jun 18. J Extracell Vesicles. 2021. PMID: 34188786 Free PMC article.

18

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact.

Chiasson MA, Rollins NJ, Stephany JJ, Sitko KA, Matreyek KA, Verby M, Sun S, Roth FP, DeSloover D, Marks DS, Rettie AE, Fowler DM. Chiasson MA, et al. Among authors: matreyek ka. Elife. 2020 Sep 1;9:e58026. doi: 10.7554/eLife.58026. Elife. 2020. PMID: 32870157 Free PMC article.

19

MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses.

Bruchez A, Sha K, Johnson J, Chen L, Stefani C, McConnell H, Gaucherand L, Prins R, Matreyek KA, Hume AJ, Mühlberger E, Schmidt EV, Olinger GG, Stuart LM, Lacy-Hulbert A. Bruchez A, et al. Among authors: matreyek ka. Science. 2020 Oct 9;370(6513):241-247. doi: 10.1126/science.abb3753. Epub 2020 Aug 27. Science. 2020. PMID: 32855215 Free PMC article.

20

High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel K_V11.1.

Kozek KA, Glazer AM, Ng CA, Blackwell D, Egly CL, Vanags LR, Blair M, Mitchell D, Matreyek KA, Fowler DM, Knollmann BC, Vandenberg JI, Roden DM, Kroncke BM. Kozek KA, et al. Among authors: matreyek ka. Heart Rhythm. 2020 Dec;17(12):2180-2189. doi: 10.1016/j.hrthm.2020.05.041. Epub 2020 Jun 6. Heart Rhythm. 2020. PMID: 32522694 Free PMC article.

21

A Premalignant Cell-Based Model for Functionalization and Classification of PTEN Variants.

Chao JT, Hollman R, Meyers WM, Meili F, Matreyek KA, Dean P, Fowler DM, Haas K, Roskelley CD, Loewen CJR. Chao JT, et al. Among authors: matreyek ka. Cancer Res. 2020 Jul 1;80(13):2775-2789. doi: 10.1158/0008-5472.CAN-19-3278. Epub 2020 May 4. Cancer Res. 2020. PMID: 32366478

22

Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity.

Suiter CC, Moriyama T, Matreyek KA, Yang W, Scaletti ER, Nishii R, Yang W, Hoshitsuki K, Singh M, Trehan A, Parish C, Smith C, Li L, Bhojwani D, Yuen LYP, Li CK, Li CH, Yang YL, Walker GJ, Goodhand JR, Kennedy NA, Klussmann FA, Bhatia S, Relling MV, Kato M, Hori H, Bhatia P, Ahmad T, Yeoh AEJ, Stenmark P, Fowler DM, Yang JJ. Suiter CC, et al. Among authors: matreyek ka. Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5394-5401. doi: 10.1073/pnas.1915680117. Epub 2020 Feb 24. Proc Natl Acad Sci U S A. 2020. PMID: 32094176 Free PMC article.

23

Deep Mutational Scan of an SCN5A Voltage Sensor.

Glazer AM, Kroncke BM, Matreyek KA, Yang T, Wada Y, Shields T, Salem JE, Fowler DM, Roden DM. Glazer AM, et al. Among authors: matreyek ka. Circ Genom Precis Med. 2020 Feb;13(1):e002786. doi: 10.1161/CIRCGEN.119.002786. Epub 2020 Jan 12. Circ Genom Precis Med. 2020. PMID: 31928070 Free PMC article.

24

An improved platform for functional assessment of large protein libraries in mammalian cells.

Matreyek KA, Stephany JJ, Chiasson MA, Hasle N, Fowler DM. Matreyek KA, et al. Nucleic Acids Res. 2020 Jan 10;48(1):e1. doi: 10.1093/nar/gkz910. Nucleic Acids Res. 2020. PMID: 31612958 Free PMC article.

25

The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes.

Hasle N, Matreyek KA, Fowler DM. Hasle N, et al. Among authors: matreyek ka. Cold Spring Harb Perspect Med. 2019 Nov 1;9(11):a036228. doi: 10.1101/cshperspect.a036228. Cold Spring Harb Perspect Med. 2019. PMID: 31451538 Free PMC article. Review.

26

Multiplex assessment of protein variant abundance by massively parallel sequencing.

Matreyek KA, Starita LM, Stephany JJ, Martin B, Chiasson MA, Gray VE, Kircher M, Khechaduri A, Dines JN, Hause RJ, Bhatia S, Evans WE, Relling MV, Yang W, Shendure J, Fowler DM. Matreyek KA, et al. Nat Genet. 2018 Jun;50(6):874-882. doi: 10.1038/s41588-018-0122-z. Epub 2018 May 21. Nat Genet. 2018. PMID: 29785012 Free PMC article.

27

On the design of CRISPR-based single-cell molecular screens.

Hill AJ, McFaline-Figueroa JL, Starita LM, Gasperini MJ, Matreyek KA, Packer J, Jackson D, Shendure J, Trapnell C. Hill AJ, et al. Among authors: matreyek ka. Nat Methods. 2018 Apr;15(4):271-274. doi: 10.1038/nmeth.4604. Epub 2018 Feb 19. Nat Methods. 2018. PMID: 29457792 Free PMC article.

28

A platform for functional assessment of large variant libraries in mammalian cells.

Matreyek KA, Stephany JJ, Fowler DM. Matreyek KA, et al. Nucleic Acids Res. 2017 Jun 20;45(11):e102. doi: 10.1093/nar/gkx183. Nucleic Acids Res. 2017. PMID: 28335006 Free PMC article.

29

Host and viral determinants for MxB restriction of HIV-1 infection.

Matreyek KA, Wang W, Serrao E, Singh PK, Levin HL, Engelman A. Matreyek KA, et al. Retrovirology. 2014 Oct 25;11:90. doi: 10.1186/s12977-014-0090-z. Retrovirology. 2014. PMID: 25348155 Free PMC article.

30

Structural insight into HIV-1 restriction by MxB.

Fribourgh JL, Nguyen HC, Matreyek KA, Alvarez FJD, Summers BJ, Dewdney TG, Aiken C, Zhang P, Engelman A, Xiong Y. Fribourgh JL, et al. Among authors: matreyek ka. Cell Host Microbe. 2014 Nov 12;16(5):627-638. doi: 10.1016/j.chom.2014.09.021. Epub 2014 Oct 9. Cell Host Microbe. 2014. PMID: 25312384 Free PMC article.

31

Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity.

Matreyek KA, Yücel SS, Li X, Engelman A. Matreyek KA, et al. PLoS Pathog. 2013;9(10):e1003693. doi: 10.1371/journal.ppat.1003693. Epub 2013 Oct 10. PLoS Pathog. 2013. PMID: 24130490 Free PMC article.

32

Viral and cellular requirements for the nuclear entry of retroviral preintegration nucleoprotein complexes.

Matreyek KA, Engelman A. Matreyek KA, et al. Viruses. 2013 Oct 7;5(10):2483-511. doi: 10.3390/v5102483. Viruses. 2013. PMID: 24103892 Free PMC article. Review.

33

Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration.

Koh Y, Wu X, Ferris AL, Matreyek KA, Smith SJ, Lee K, KewalRamani VN, Hughes SH, Engelman A. Koh Y, et al. Among authors: matreyek ka. J Virol. 2013 Jan;87(1):648-58. doi: 10.1128/JVI.01148-12. Epub 2012 Oct 24. J Virol. 2013. PMID: 23097450 Free PMC article.

34

Viral latency and potential eradication of HIV-1.

Matreyek KA, Oztop I, Freed EO, Engelman A. Matreyek KA, et al. Expert Rev Anti Infect Ther. 2012 Aug;10(8):855-7. doi: 10.1586/eri.12.68. Expert Rev Anti Infect Ther. 2012. PMID: 23030323 Free PMC article.

35

The requirement for nucleoporin NUP153 during human immunodeficiency virus type 1 infection is determined by the viral capsid.

Matreyek KA, Engelman A. Matreyek KA, et al. J Virol. 2011 Aug;85(15):7818-27. doi: 10.1128/JVI.00325-11. Epub 2011 May 18. J Virol. 2011. PMID: 21593146 Free PMC article.

36

Differential sensitivities of retroviruses to integrase strand transfer inhibitors.

Koh Y, Matreyek KA, Engelman A. Koh Y, et al. Among authors: matreyek ka. J Virol. 2011 Apr;85(7):3677-82. doi: 10.1128/JVI.02541-10. Epub 2011 Jan 26. J Virol. 2011. PMID: 21270168 Free PMC article.

37

The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase.

Krishnan L, Matreyek KA, Oztop I, Lee K, Tipper CH, Li X, Dar MJ, Kewalramani VN, Engelman A. Krishnan L, et al. Among authors: matreyek ka. J Virol. 2010 Jan;84(1):397-406. doi: 10.1128/JVI.01899-09. Epub 2009 Oct 21. J Virol. 2010. PMID: 19846519 Free PMC article.

38

Polybasic KKR motif in the cytoplasmic tail of Nipah virus fusion protein modulates membrane fusion by inside-out signaling.

Aguilar HC, Matreyek KA, Choi DY, Filone CM, Young S, Lee B. Aguilar HC, et al. Among authors: matreyek ka. J Virol. 2007 May;81(9):4520-32. doi: 10.1128/JVI.02205-06. Epub 2007 Feb 14. J Virol. 2007. PMID: 17301148 Free PMC article.

39

N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry.

Aguilar HC, Matreyek KA, Filone CM, Hashimi ST, Levroney EL, Negrete OA, Bertolotti-Ciarlet A, Choi DY, McHardy I, Fulcher JA, Su SV, Wolf MC, Kohatsu L, Baum LG, Lee B. Aguilar HC, et al. Among authors: matreyek ka. J Virol. 2006 May;80(10):4878-89. doi: 10.1128/JVI.80.10.4878-4889.2006. J Virol. 2006. PMID: 16641279 Free PMC article.

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