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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1967 5
1968 11
1969 19
1970 56
1971 141
1972 166
1973 193
1974 194
1975 181
1976 154
1977 179
1978 188
1979 164
1980 178
1981 158
1982 186
1983 173
1984 210
1985 206
1986 220
1987 239
1988 229
1989 296
1990 333
1991 306
1992 264
1993 281
1994 316
1995 312
1996 298
1997 317
1998 314
1999 342
2000 391
2001 393
2002 401
2003 411
2004 454
2005 479
2006 472
2007 515
2008 563
2009 558
2010 647
2011 691
2012 803
2013 836
2014 932
2015 1066
2016 1032
2017 1137
2018 1216
2019 1281
2020 1493
2021 1622
2022 1592
2023 141
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23,698 results
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Page 1
Mechanisms of ketamine action as an antidepressant.
Zanos P, Gould TD. Zanos P, et al. Mol Psychiatry. 2018 Apr;23(4):801-811. doi: 10.1038/mp.2017.255. Epub 2018 Mar 13. Mol Psychiatry. 2018. PMID: 29532791 Free PMC article. Review.
Recent preclinical research has focused on unraveling the molecular mechanisms underlying the antidepressant actions of ketamine in an effort to develop novel pharmacotherapies, which will mimic ketamine's antidepressant actions but lack its undesirable effec …
Recent preclinical research has focused on unraveling the molecular mechanisms underlying the antidepressant actions of ketamine in a …
Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis.
Bahji A, Vazquez GH, Zarate CA Jr. Bahji A, et al. J Affect Disord. 2021 Jan 1;278:542-555. doi: 10.1016/j.jad.2020.09.071. Epub 2020 Sep 23. J Affect Disord. 2021. PMID: 33022440 Free PMC article. Review.
FINDINGS: 24 trials representing 1877 participants were pooled. Racemic ketamine relative to esketamine demonstrated greater overall response (RR = 3.01 vs. ...RR = 1.47), as well as lower dropouts (RR = 0.76 vs. RR = 1.37). CONCLUSIONS: Intravenous ketamine …
FINDINGS: 24 trials representing 1877 participants were pooled. Racemic ketamine relative to esketamine demonstrated greater o …
Therapeutic Mechanisms of Ketamine.
Mihaljević S, Pavlović M, Reiner K, Ćaćić M. Mihaljević S, et al. Psychiatr Danub. 2020 Autumn-Winter;32(3-4):325-333. doi: 10.24869/psyd.2020.325. Psychiatr Danub. 2020. PMID: 33370729 Free article. Review.
However, unique pharmacodynamic properties of ketamine have increased interests in it's use for treatment of depression. ...Acute side effects, such as increased salivation, increase in heart rate, systemic arterial pressure and intracranial pressure necessitate car …
However, unique pharmacodynamic properties of ketamine have increased interests in it's use for treatment of depression. ...Ac …
Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms.
Zanos P, Moaddel R, Morris PJ, Riggs LM, Highland JN, Georgiou P, Pereira EFR, Albuquerque EX, Thomas CJ, Zarate CA Jr, Gould TD. Zanos P, et al. Pharmacol Rev. 2018 Jul;70(3):621-660. doi: 10.1124/pr.117.015198. Pharmacol Rev. 2018. PMID: 29945898 Free PMC article. Review.
Ketamine, a racemic mixture consisting of (S)- and (R)-ketamine, has been in clinical use since 1970. ...Dissociative, psychotomimetic, cognitive, and peripheral side effects associated with short-term or prolonged exposure, as well as recreational ketamin …
Ketamine, a racemic mixture consisting of (S)- and (R)-ketamine, has been in clinical use since 1970. ...Dissociative, …
Ketamine.
Sinner B, Graf BM. Sinner B, et al. Handb Exp Pharmacol. 2008;(182):313-33. doi: 10.1007/978-3-540-74806-9_15. Handb Exp Pharmacol. 2008. PMID: 18175098 Review.
There are two optical isomers of the 2-(2-chlorophenyl)-2-(methylamino)-cyclohexanone ketamine: S(+) ketamine and R(-) ketamine. Effects of this drug are mediated by N-methyl-d-aspartate (NMDA), opioid, muscarinic and different voltage-gated receptors. …
There are two optical isomers of the 2-(2-chlorophenyl)-2-(methylamino)-cyclohexanone ketamine: S(+) ketamine and R(-) …
Esketamine for treatment resistant depression.
Swainson J, Thomas RK, Archer S, Chrenek C, MacKay MA, Baker G, Dursun S, Klassen LJ, Chokka P, Demas ML. Swainson J, et al. Expert Rev Neurother. 2019 Oct;19(10):899-911. doi: 10.1080/14737175.2019.1640604. Epub 2019 Jul 16. Expert Rev Neurother. 2019. PMID: 31282772 Review.
Introduction: Treatment Resistant Depression (TRD) is a common and burdensome condition with poor outcomes and few treatment options. Esketamine is the S-enantiomer of ketamine and has recently been FDA approved in the United States for treating depression th …
Introduction: Treatment Resistant Depression (TRD) is a common and burdensome condition with poor outcomes and few treatment options. Esk …
Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.
McIntyre RS, Rosenblat JD, Nemeroff CB, Sanacora G, Murrough JW, Berk M, Brietzke E, Dodd S, Gorwood P, Ho R, Iosifescu DV, Lopez Jaramillo C, Kasper S, Kratiuk K, Lee JG, Lee Y, Lui LMW, Mansur RB, Papakostas GI, Subramaniapillai M, Thase M, Vieta E, Young AH, Zarate CA Jr, Stahl S. McIntyre RS, et al. Am J Psychiatry. 2021 May 1;178(5):383-399. doi: 10.1176/appi.ajp.2020.20081251. Epub 2021 Mar 17. Am J Psychiatry. 2021. PMID: 33726522 Free PMC article. Review.
Despite the proven efficacy of monoamine-based antidepressants in major depression, the majority of treated individuals fail to achieve full syndromal and functional recovery with the index and subsequent pharmacological treatments. Ketamine and esketamine represent …
Despite the proven efficacy of monoamine-based antidepressants in major depression, the majority of treated individuals fail to achieve full …
Ketamine use in current clinical practice.
Gao M, Rejaei D, Liu H. Gao M, et al. Acta Pharmacol Sin. 2016 Jul;37(7):865-72. doi: 10.1038/aps.2016.5. Epub 2016 Mar 28. Acta Pharmacol Sin. 2016. PMID: 27018176 Free PMC article. Review.
Over the last two decades, much research has been conducted highlighting the drug's mechanisms of action, specifically those of its enantiomers. ...Recently, new insights have been gained on ketamine's potential anti-depressive and antisuicidal effects. This …
Over the last two decades, much research has been conducted highlighting the drug's mechanisms of action, specifically those of its e …
Ketamine for depression clinical issues.
Iqbal SZ, Mathew SJ. Iqbal SZ, et al. Adv Pharmacol. 2020;89:131-162. doi: 10.1016/bs.apha.2020.02.005. Epub 2020 Apr 1. Adv Pharmacol. 2020. PMID: 32616205 Review.
Ketamine is a racemic mixture comprised of two enantiomers (R)-ketamine and (S)-ketamine and acts as an NMDA receptor antagonist. ...However, ketamine is a scheduled agent with abuse potential, making its long-term use challenging and mandating …
Ketamine is a racemic mixture comprised of two enantiomers (R)-ketamine and (S)-ketamine and acts as an NMDA rec …
Ketamine applications beyond anesthesia - A literature review.
Nowacka A, Borczyk M. Nowacka A, et al. Eur J Pharmacol. 2019 Oct 5;860:172547. doi: 10.1016/j.ejphar.2019.172547. Epub 2019 Jul 23. Eur J Pharmacol. 2019. PMID: 31348905 Review.
Ketamine's clinical use began in the 1970s. Physicians benefited from its safety and ability to induce short-term anesthesia and analgesia. ...This review aims to discuss the well-known and new promising applications of ketamine....
Ketamine's clinical use began in the 1970s. Physicians benefited from its safety and ability to induce short-term anesthesia a …
23,698 results
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