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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 1
1971 2
1972 8
1973 9
1974 9
1975 20
1976 11
1977 10
1978 13
1979 14
1980 14
1981 13
1982 22
1983 8
1984 24
1985 22
1986 14
1987 22
1988 21
1989 26
1990 31
1991 20
1992 23
1993 14
1994 22
1995 28
1996 20
1997 30
1998 25
1999 22
2000 18
2001 19
2002 22
2003 22
2004 30
2005 25
2006 24
2007 32
2008 38
2009 52
2010 63
2011 74
2012 119
2013 166
2014 204
2015 255
2016 264
2017 303
2018 329
2019 426
2020 552
2021 599
2022 614
2023 173
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4,299 results
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Page 1
Ketamine and depression: a narrative review.
Corriger A, Pickering G. Corriger A, et al. Drug Des Devel Ther. 2019 Aug 27;13:3051-3067. doi: 10.2147/DDDT.S221437. eCollection 2019. Drug Des Devel Ther. 2019. PMID: 31695324 Free PMC article. Review.
It was restricted to Cochrane reviews, meta-analyses, and randomized controlled trials (RCTs) of ketamine for major depressive disorder and/or bipolar disorder. This review included two Cochrane reviews, 14 meta-analyses and 15 trials. ...Intranasal ( …
It was restricted to Cochrane reviews, meta-analyses, and randomized controlled trials (RCTs) of ketamine for major depressive
Ketamine for depression.
Jelen LA, Stone JM. Jelen LA, et al. Int Rev Psychiatry. 2021 May;33(3):207-228. doi: 10.1080/09540261.2020.1854194. Epub 2021 Feb 11. Int Rev Psychiatry. 2021. PMID: 33569971 Review.
Ketamine is a racemic mixture composed of equal amounts of (S)-ketamine and (R)-ketamine. Although ketamine currently remains an off-label treatment for TRD, an (S)-ketamine nasal spray has been approved for use in TRD (in conjunct
Ketamine is a racemic mixture composed of equal amounts of (S)-ketamine and (R)-ketamine. Although ketamine
Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis.
Bahji A, Vazquez GH, Zarate CA Jr. Bahji A, et al. J Affect Disord. 2021 Jan 1;278:542-555. doi: 10.1016/j.jad.2020.09.071. Epub 2020 Sep 23. J Affect Disord. 2021. PMID: 33022440 Free PMC article. Review.
BACKGROUND: Ketamine appears to have a therapeutic role in certain mental disorders, most notably depression. ...RR = 1.47), as well as lower dropouts (RR = 0.76 vs. RR = 1.37). CONCLUSIONS: Intravenous ketamine appears to be more efficacious than intranasal …
BACKGROUND: Ketamine appears to have a therapeutic role in certain mental disorders, most notably depression. ...RR = 1.47), a …
Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.
McIntyre RS, Rosenblat JD, Nemeroff CB, Sanacora G, Murrough JW, Berk M, Brietzke E, Dodd S, Gorwood P, Ho R, Iosifescu DV, Lopez Jaramillo C, Kasper S, Kratiuk K, Lee JG, Lee Y, Lui LMW, Mansur RB, Papakostas GI, Subramaniapillai M, Thase M, Vieta E, Young AH, Zarate CA Jr, Stahl S. McIntyre RS, et al. Am J Psychiatry. 2021 May 1;178(5):383-399. doi: 10.1176/appi.ajp.2020.20081251. Epub 2021 Mar 17. Am J Psychiatry. 2021. PMID: 33726522 Free PMC article. Review.
Ketamine and esketamine represent pharmacologically novel treatment avenues for adults with treatment-resistant depression. In addition to providing hope to affected persons, these agents represent the first non-monoaminergic agents with proven rapid-onset ef
Ketamine and esketamine represent pharmacologically novel treatment avenues for adults with treatment-resistant depression
Efficacy of Intravenous Ketamine in Adolescent Treatment-Resistant Depression: A Randomized Midazolam-Controlled Trial.
Dwyer JB, Landeros-Weisenberger A, Johnson JA, Londono Tobon A, Flores JM, Nasir M, Couloures K, Sanacora G, Bloch MH. Dwyer JB, et al. Am J Psychiatry. 2021 Apr 1;178(4):352-362. doi: 10.1176/appi.ajp.2020.20010018. Epub 2021 Mar 3. Am J Psychiatry. 2021. PMID: 33653121 Clinical Trial.
The authors conducted an active-placebo-controlled study of ketamine's safety and efficacy in adolescents. METHODS: In this proof-of-concept randomized, double-blind, single-dose crossover clinical trial, 17 adolescents (ages 13-17) with a diagnosis of major depr
The authors conducted an active-placebo-controlled study of ketamine's safety and efficacy in adolescents. METHODS: In this pr …
Ketamine for depression clinical issues.
Iqbal SZ, Mathew SJ. Iqbal SZ, et al. Adv Pharmacol. 2020;89:131-162. doi: 10.1016/bs.apha.2020.02.005. Epub 2020 Apr 1. Adv Pharmacol. 2020. PMID: 32616205 Review.
Major depressive disorder (MDD) is a debilitating illness with significant morbidity and mortality, leading to attempted and completed suicides. ...Ketamine is a racemic mixture comprised of two enantiomers (R)-ketamine and (S)-ketamine a …
Major depressive disorder (MDD) is a debilitating illness with significant morbidity and mortality, leading to attempted and c …
Oral Ketamine for Depression: A Systematic Review.
Rosenblat JD, Carvalho AF, Li M, Lee Y, Subramanieapillai M, McIntyre RS. Rosenblat JD, et al. J Clin Psychiatry. 2019 Apr 16;80(3):18r12475. doi: 10.4088/JCP.18r12475. J Clin Psychiatry. 2019. PMID: 30995364
The objective of the current systematic review, in accordance with PRISMA, is to determine the efficacy, safety, tolerability, and dose range of oral ketamine for bipolar and unipolar depression. DATA SOURCES: The MEDLINE/PubMed, EMBASE, and Google Scholar databases …
The objective of the current systematic review, in accordance with PRISMA, is to determine the efficacy, safety, tolerability, and dose rang …
Use of ketamine and esketamine for depression: an overview of systematic reviews with meta-analyses.
Lima TM, Visacri MB, Aguiar PM. Lima TM, et al. Eur J Clin Pharmacol. 2022 Mar;78(3):311-338. doi: 10.1007/s00228-021-03216-8. Epub 2021 Oct 27. Eur J Clin Pharmacol. 2022. PMID: 34705064 Review.
PURPOSE: To summarize the evidence of efficacy and safety of the use of ketamine and esketamine for depression. METHODS: A literature search was performed in Medline, the Cochrane Library, LILACS, and CRD until November 2020. ...Ketamine and esketam
PURPOSE: To summarize the evidence of efficacy and safety of the use of ketamine and esketamine for depression. METHODS …
Maintenance ketamine treatment for depression: a systematic review of efficacy, safety, and tolerability.
Smith-Apeldoorn SY, Veraart JK, Spijker J, Kamphuis J, Schoevers RA. Smith-Apeldoorn SY, et al. Lancet Psychiatry. 2022 Nov;9(11):907-921. doi: 10.1016/S2215-0366(22)00317-0. Lancet Psychiatry. 2022. PMID: 36244360 Review.
Ketamine has rapid yet often transient antidepressant effects in patients with treatment-resistant depression. Different strategies have been proposed to prolong these effects. Maintenance ketamine treatment appears promising, but little is known about its ef
Ketamine has rapid yet often transient antidepressant effects in patients with treatment-resistant depression. Different strat
Long-term safety of ketamine and esketamine in treatment of depression.
Nikayin S, Murphy E, Krystal JH, Wilkinson ST. Nikayin S, et al. Expert Opin Drug Saf. 2022 Jun;21(6):777-787. doi: 10.1080/14740338.2022.2066651. Epub 2022 Apr 19. Expert Opin Drug Saf. 2022. PMID: 35416105 Review.
INTRODUCTION: Ketamine can produce rapid-acting antidepressant effects. Esketamine (Spravato), the S-enantiomer of racemic ketamine, was approved by the FDA for treatment-resistant depression in 2019. ...However, severe bladder pathology has not …
INTRODUCTION: Ketamine can produce rapid-acting antidepressant effects. Esketamine (Spravato), the S-enantiomer of race …
4,299 results