Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1997 2
1998 2
1999 1
2000 1
2004 1
2005 1
2006 2
2008 2
2009 3
2010 3
2011 2
2012 9
2013 6
2014 19
2015 16
2016 16
2017 23
2018 23
2019 24
2020 37
2021 30
2022 34
2023 37
2024 40
2025 33
2026 20

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

319 results

Results by year

Filters applied: . Clear all
Page 1
Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial.
Phillips JL, Norris S, Talbot J, Birmingham M, Hatchard T, Ortiz A, Owoeye O, Batten LA, Blier P. Phillips JL, et al. Am J Psychiatry. 2019 May 1;176(5):401-409. doi: 10.1176/appi.ajp.2018.18070834. Epub 2019 Mar 29. Am J Psychiatry. 2019. PMID: 30922101 Clinical Trial.
The purpose of this study was to evaluate the antidepressant effects of a single ketamine infusion, a series of repeated ketamine infusions, and prolongation of response with maintenance infusions. ...Participants had no further change in MADRS …
The purpose of this study was to evaluate the antidepressant effects of a single ketamine infusion, a series of repeated ke …
Ketamine for Chronic Pain and Mental Health: Regulations, Legalities, and the Growth of Infusion Clinics.
Bloomfield A, Chan N, Fryml L, Horace R, Pyati S. Bloomfield A, et al. Curr Pain Headache Rep. 2023 Oct;27(10):579-585. doi: 10.1007/s11916-023-01150-1. Epub 2023 Aug 12. Curr Pain Headache Rep. 2023. PMID: 37572245 Review.
PURPOSE OF REVIEW: In this article, we will review evidence for ketamine's role in chronic pain and mental health conditions, its current legal status and abuse potential, and the regulations related to its administration in stand-alone infusion …
PURPOSE OF REVIEW: In this article, we will review evidence for ketamine's role in chronic pain and mental health …
Effect of Intraoperative Esketamine Infusion on Postoperative Sleep Disturbance After Gynecological Laparoscopy: A Randomized Clinical Trial.
Qiu D, Wang XM, Yang JJ, Chen S, Yue CB, Hashimoto K, Yang JJ. Qiu D, et al. JAMA Netw Open. 2022 Dec 1;5(12):e2244514. doi: 10.1001/jamanetworkopen.2022.44514. JAMA Netw Open. 2022. PMID: 36454569 Free PMC article. Clinical Trial.
OBJECTIVE: To examine the effect of intraoperative esketamine infusion on the incidence of PSD in patients who underwent gynecological laparoscopic surgery. ...Patients were randomly assigned to either the esketamine group or control group. Data were analyzed …
OBJECTIVE: To examine the effect of intraoperative esketamine infusion on the incidence of PSD in patients who underwent gynec …
Ketamine treatment for depression: a review.
Yavi M, Lee H, Henter ID, Park LT, Zarate CA Jr. Yavi M, et al. Discov Ment Health. 2022;2(1):9. doi: 10.1007/s44192-022-00012-3. Epub 2022 Apr 15. Discov Ment Health. 2022. PMID: 35509843 Free PMC article. Review.
This manuscript reviews the clinical evidence regarding single-dose intravenous (IV) administration of the novel glutamatergic modulator racemic (R,S)-ketamine (hereafter referred to as ketamine) as well as its S-enantiomer, intranasal esketamine, for …
This manuscript reviews the clinical evidence regarding single-dose intravenous (IV) administration of the novel glutamatergic modulator rac …
Antidepressant effects of ketamine in depressed patients.
Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, Krystal JH. Berman RM, et al. Biol Psychiatry. 2000 Feb 15;47(4):351-4. doi: 10.1016/s0006-3223(99)00230-9. Biol Psychiatry. 2000. PMID: 10686270 Clinical Trial.
METHODS: Seven subjects with major depression completed 2 test days that involved intravenous treatment with ketamine hydrochloride (.5 mg/kg) or saline solutions under randomized, double-blind conditions. RESULTS: Subjects with depression evidenced significant improvement …
METHODS: Seven subjects with major depression completed 2 test days that involved intravenous treatment with ketamine hydrochloride ( …
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate CA Jr, Singh JB, Carlson PJ, Brutsche NE, Ameli R, Luckenbaugh DA, Charney DS, Manji HK. Zarate CA Jr, et al. Arch Gen Psychiatry. 2006 Aug;63(8):856-64. doi: 10.1001/archpsyc.63.8.856. Arch Gen Psychiatry. 2006. PMID: 16894061 Clinical Trial.
SETTING: Mood Disorders Research Unit at the National Institute of Mental Health. Patients Eighteen subjects with DSM-IV major depression (treatment resistant). INTERVENTIONS: After a 2-week drug-free period, subjects were given an intravenous infusion of eit …
SETTING: Mood Disorders Research Unit at the National Institute of Mental Health. Patients Eighteen subjects with DSM-IV major …
Efficacy of a single low dose of esketamine after childbirth for mothers with symptoms of prenatal depression: randomised clinical trial.
Wang S, Deng CM, Zeng Y, Chen XZ, Li AY, Feng SW, Xu LL, Chen L, Yuan HM, Hu H, Yang T, Han T, Zhang HY, Jiang M, Sun XY, Guo HN, Sessler DI, Wang DX. Wang S, et al. BMJ. 2024 Apr 10;385:e078218. doi: 10.1136/bmj-2023-078218. BMJ. 2024. PMID: 38808490 Free PMC article. Clinical Trial.
OBJECTIVE: To determine whether a single low dose of esketamine administered after childbirth reduces postpartum depression in mothers with prenatal depression. ...INTERVENTIONS: Participants were randomly assigned 1:1 to receive either 0.2 mg/kg esketamine or place …
OBJECTIVE: To determine whether a single low dose of esketamine administered after childbirth reduces postpartum depression in mother …
Ketamine for the acute treatment of severe suicidal ideation: double blind, randomised placebo controlled trial.
Abbar M, Demattei C, El-Hage W, Llorca PM, Samalin L, Demaricourt P, Gaillard R, Courtet P, Vaiva G, Gorwood P, Fabbro P, Jollant F. Abbar M, et al. BMJ. 2022 Feb 2;376:e067194. doi: 10.1136/bmj-2021-067194. BMJ. 2022. PMID: 35110300 Free PMC article. Clinical Trial.
INTERVENTION: Two 40 minute intravenous infusions of ketamine (0.5 mg/kg) or placebo (saline) were administered at baseline and 24 hours, in addition to usual treatment. ...Comorbid mental disorders appear to be important moderators. An analgesic effect on …
INTERVENTION: Two 40 minute intravenous infusions of ketamine (0.5 mg/kg) or placebo (saline) were administered at baseline an …
Hippocampal PACAP signaling activation triggers a rapid antidepressant response.
Zhang HL, Sun Y, Wu ZJ, Yin Y, Liu RY, Zhang JC, Zhang ZJ, Yau SY, Wu HX, Yuan TF, Zhang L, Adzic M, Chen G. Zhang HL, et al. Mil Med Res. 2024 Jul 23;11(1):49. doi: 10.1186/s40779-024-00548-1. Mil Med Res. 2024. PMID: 39044298 Free PMC article.
BACKGROUND: The development of ketamine-like rapid antidepressants holds promise for enhancing the therapeutic efficacy of depression, but the underlying cellular and molecular mechanisms remain unclear. ...Pre-activation of CaMKII signaling within the DG blunted PACAP-ind …
BACKGROUND: The development of ketamine-like rapid antidepressants holds promise for enhancing the therapeutic efficacy of depression …
319 results