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Page 1
Mast Cell Activation Syndrome.
Frieri M. Frieri M. Clin Rev Allergy Immunol. 2018 Jun;54(3):353-365. doi: 10.1007/s12016-015-8487-6. Clin Rev Allergy Immunol. 2018. PMID: 25944644 Review.
Mast cell activation syndrome (MCAS) involves the skin, gastrointestinal, cardiovascular, respiratory, and neurologic systems, classified as primary, secondary, and idiopathic. ...A recent global classification is a response of clinical symptoms, a substantial trans …
Mast cell activation syndrome (MCAS) involves the skin, gastrointestinal, cardiovascular, respiratory, and neurologic systems, …
Mast Cell Stabilizer Ketotifen Inhibits Gouty Inflammation in Rats.
Hsu DZ, Chu PY, Chen SJ, Liu MY. Hsu DZ, et al. Am J Ther. 2016 Jul-Aug;23(4):e1009-15. doi: 10.1097/MJT.0b013e31829ea238. Am J Ther. 2016. PMID: 23884077
We examined the therapeutic effect of ketotifen, a mast cell stabilizer, on monosodium urate (MSU) crystal-induced acute inflammation. ...Ketotifen significantly inhibited MSU-induced mast cell activation and histamine concentration in ai …
We examined the therapeutic effect of ketotifen, a mast cell stabilizer, on monosodium urate (MSU) crystal-induced acut …
Efficacy of mast cell directed therapies in irritable bowel syndrome: a systematic review.
Coppens D, Kips M, Stiévenard T, Mertens C, De Schepper H. Coppens D, et al. Acta Gastroenterol Belg. 2024 Jan-Mar;87(1):15-27. doi: 10.51821/87.1.12487. Acta Gastroenterol Belg. 2024. PMID: 38431786 Free article.
BACKGROUND AND STUDY AIM: Lately, mast cells (MCs) are increasingly implicated in the pathophysiology of irritable bowel syndrome (IBS). The aim of this systematic review was to assess the efficacy of mast cell directed therapies in reducing the main s …
BACKGROUND AND STUDY AIM: Lately, mast cells (MCs) are increasingly implicated in the pathophysiology of irritable bowel syndr …
Mast cell stabilizer ketotifen reduces hyperalgesia in a rodent model of surgically induced endometriosis.
Zhu TH, Zou G, Ding SJ, Li TT, Zhu LB, Wang JZ, Yao YX, Zhang XM. Zhu TH, et al. J Pain Res. 2019 Apr 29;12:1359-1369. doi: 10.2147/JPR.S195909. eCollection 2019. J Pain Res. 2019. PMID: 31118754 Free PMC article.
Purpose: This study aimed to investigate the effect of oral treatment with ketotifen, a mast cell (MC) stabilizer, in a rat model of surgically induced endometriosis. ...Our results suggest that ketotifen may inhibit the development of endometriotic le …
Purpose: This study aimed to investigate the effect of oral treatment with ketotifen, a mast cell (MC) stabilizer, in a …
Mast cell-mediated splanchnic cholestatic inflammation.
Aller MÁ, Martínez V, Arias A, Nava MP, Cuervas-Mons V, Vergara P, Arias J. Aller MÁ, et al. Clin Res Hepatol Gastroenterol. 2019 Oct;43(5):561-574. doi: 10.1016/j.clinre.2019.02.001. Epub 2019 Mar 8. Clin Res Hepatol Gastroenterol. 2019. PMID: 30853494
INTRODUCTION: Splanchnic mast cells increase in chronic liver and in acute-on-chronic liver diseases. We administered Ketotifen, a mast cell stabilizer, and measured the mast cells in the splanchnic organs of cholestatic rats. ... …
INTRODUCTION: Splanchnic mast cells increase in chronic liver and in acute-on-chronic liver diseases. We administered Ketot …
Anti-Allergic Drugs Tranilast and Ketotifen Dose-Dependently Exert Mast Cell-Stabilizing Properties.
Baba A, Tachi M, Ejima Y, Endo Y, Toyama H, Matsubara M, Saito K, Yamauchi M, Miura C, Kazama I. Baba A, et al. Cell Physiol Biochem. 2016;38(1):15-27. doi: 10.1159/000438605. Epub 2016 Jan 8. Cell Physiol Biochem. 2016. PMID: 26741745 Free article.
BACKGROUND: Anti-allergic drugs, such as tranilast and ketotifen, inhibit the release of chemokines from mast cells. However, we know little about their direct effects on the exocytotic process of mast cells. ...The mast cell-stabi …
BACKGROUND: Anti-allergic drugs, such as tranilast and ketotifen, inhibit the release of chemokines from mast cells. Ho …
Ketotifen Modulates Mast Cell Chemotaxis to Kit-Ligand, but Does Not Impact Mast Cell Numbers, Degranulation, or Tumor Behavior in Neurofibromas of Nf1-Deficient Mice.
Burks CA, Rhodes SD, Bessler WK, Chen S, Smith A, Gehlhausen JR, Hawley ET, Jiang L, Li X, Yuan J, Lu Q, Jacobsen M, Sandusky GE, Jones DR, Clapp DW, Blakeley JO. Burks CA, et al. Mol Cancer Ther. 2019 Dec;18(12):2321-2330. doi: 10.1158/1535-7163.MCT-19-0123. Epub 2019 Sep 16. Mol Cancer Ther. 2019. PMID: 31527226 Free PMC article.
Ketotifen is an FDA-approved drug for the treatment of allergic conjunctivitis and asthma that promotes mast cell stabilization and has been used in prior case studies to treat or prevent pNFs. ...Ketotifen decreased mast cell infiltratio …
Ketotifen is an FDA-approved drug for the treatment of allergic conjunctivitis and asthma that promotes mast cell stabi …
Mast cell stabilizer ketotifen fumarate reverses inflammatory but not neuropathic-induced mechanical pain in mice.
Meloto CB, Ingelmo P, Perez EV, Pitt R, González Cárdenas VH, Mohamed N, Sotocinal SG, Bourassa V, Lima LV, Ribeiro-da-Silva A, Mogil JS, Diatchenko L. Meloto CB, et al. Pain Rep. 2021 Jun 3;6(2):e902. doi: 10.1097/PR9.0000000000000902. eCollection 2021 Jul-Aug. Pain Rep. 2021. PMID: 34104835 Free PMC article.
INTRODUCTION: Mast cell (MC) activation could establish a positive feedback loop that perpetuates inflammation and maintains pain. Stabilizing MCs with ketotifen fumarate (KF) may disrupt this loop and relieve pain. OBJECTIVE: We aimed to test the effect of t …
INTRODUCTION: Mast cell (MC) activation could establish a positive feedback loop that perpetuates inflammation and maintains p …
Mast cell degranulation in rat mesenteric venule: effects of L-NAME, methylene blue and ketotifen.
Kimura M, Mitani H, Bandoh T, Totsuka T, Hayashi S. Kimura M, et al. Pharmacol Res. 1999 May;39(5):397-402. doi: 10.1006/phrs.1999.0451. Pharmacol Res. 1999. PMID: 10328998
The degranulation was associated with increased adhesion of leukocytes to the endothelium and the slowed rolling. Pretreatment with ketotifen at an oral dose of 1 mg kg-1 inhibited mast cell degranulation in responses to either L-NAME or MB. It is conceivable …
The degranulation was associated with increased adhesion of leukocytes to the endothelium and the slowed rolling. Pretreatment with ketot …
The mast cell stabilizer ketotifen fumarate lessens contracture severity and myofibroblast hyperplasia: a study of a rabbit model of posttraumatic joint contractures.
Monument MJ, Hart DA, Befus AD, Salo PT, Zhang M, Hildebrand KA. Monument MJ, et al. J Bone Joint Surg Am. 2010 Jun;92(6):1468-77. doi: 10.2106/JBJS.I.00684. J Bone Joint Surg Am. 2010. PMID: 20516323 Free PMC article.
Affected joint capsules become fibrotic, characterized by myofibroblast and collagen hyperplasia. Mast cell hyperplasia is common within fibrotic tissue, and mast cells are known to synthesize many profibrotic mediators. ...The joint capsule myofibrobl …
Affected joint capsules become fibrotic, characterized by myofibroblast and collagen hyperplasia. Mast cell hyperplasia is com …
484 results