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337 results

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Page 1
FKBP5 deficiency attenuates calcium oxalate kidney stone formation by suppressing cell-crystal adhesion, apoptosis and macrophage M1 polarization via inhibition of NF-kappaB signaling.
Song Q, Song C, Chen X, Xiong Y, Li L, Liao W, Xue L, Yang S. Song Q, et al. Cell Mol Life Sci. 2023 Sep 23;80(10):301. doi: 10.1007/s00018-023-04958-7. Cell Mol Life Sci. 2023. PMID: 37740796 Free PMC article.
Lentivirus and adeno-associated virus were used to control FKBP5 expression in a CaOx kidney stone model. Transcriptomic sequencing and immunological assays were used to analyze the mechanism of FKBP5 deficiency in CaOx kidney stones. ...Finally, in vivo expe …
Lentivirus and adeno-associated virus were used to control FKBP5 expression in a CaOx kidney stone model. Transcriptomic seque …
Kidney stone matrix proteins: Role in stone formation.
Negri AL, Spivacow FR. Negri AL, et al. World J Nephrol. 2023 Mar 25;12(2):21-28. doi: 10.5527/wjn.v12.i2.21. World J Nephrol. 2023. PMID: 37035509 Free PMC article. Review.
Proteins are the most abundant component of kidney stone matrix, and their presence may reflect the process of stone formation. Many recent studies have explored the proteomics of urinary stones. ...Many of these proteins have other functions in modulating ox …
Proteins are the most abundant component of kidney stone matrix, and their presence may reflect the process of stone fo …
Novel Biocompatible Adhesive to Remove Stone Dust: Usability Trial in a Kidney Model.
Hausmann T, Becker B, Gross AJ, Netsch C, Rosenbaum CM. Hausmann T, et al. J Endourol. 2021 Aug;35(8):1223-1228. doi: 10.1089/end.2020.0748. Epub 2021 Apr 15. J Endourol. 2021. PMID: 33559523
Introduction and Objective: "Clinically insignificant residual fragments" are an independent predictive factor for recurrence of nephrolithiasis. To improve the stone-free rates (SFR), we tested the viability of a novel bioadhesive system for intrarenal embedding and retri …
Introduction and Objective: "Clinically insignificant residual fragments" are an independent predictive factor for recurrence of nephrolithi …
Application of metabolomics in urolithiasis: the discovery and usage of succinate.
Zhang XZ, Lei XX, Jiang YL, Zhao LM, Zou CY, Bai YJ, Li YX, Wang R, Li QJ, Chen QZ, Fan MH, Song YT, Zhang WQ, Zhang Y, Li-Ling J, Xie HQ. Zhang XZ, et al. Signal Transduct Target Ther. 2023 Jan 21;8(1):41. doi: 10.1038/s41392-023-01311-z. Signal Transduct Target Ther. 2023. PMID: 36681678 Free PMC article.
Urinary stone is conceptualized as a chronic metabolic disorder punctuated by symptomatic stone events. ...We thereby assessed the impact of the inhibitors with an EG-induced rat model for kidney stones. Notably, succinate, a key player in the tricarboxylic a …
Urinary stone is conceptualized as a chronic metabolic disorder punctuated by symptomatic stone events. ...We thereby assessed …
Inhibition of sodium-glucose cotransporter 2 suppresses renal stone formation.
Anan G, Hirose T, Kikuchi D, Takahashi C, Endo A, Ito H, Sato S, Nakayama S, Hashimoto H, Ishiyama K, Kimura T, Takahashi K, Sato M, Mori T. Anan G, et al. Pharmacol Res. 2022 Dec;186:106524. doi: 10.1016/j.phrs.2022.106524. Epub 2022 Oct 28. Pharmacol Res. 2022. PMID: 36349594 Free article.
RESULTS: Nephrolithiasis prevalence in diabetic men was significantly lower in the SGLT2 inhibitor prescription group than in the non-SGLT2 inhibitor prescription group. Phlorizin attenuated renal stone formation and downregulated the kidney injury molecule 1 (Kim1) …
RESULTS: Nephrolithiasis prevalence in diabetic men was significantly lower in the SGLT2 inhibitor prescription group than in the non-SGLT2 …
Proteomics of Crystal-Cell Interactions: A Model for Kidney Stone Research.
Thongboonkerd V. Thongboonkerd V. Cells. 2019 Sep 12;8(9):1076. doi: 10.3390/cells8091076. Cells. 2019. PMID: 31547429 Free PMC article. Review.
Nephrolithiasis/urolithiasis (i.e., kidney stone disease) remains a global public health problem with increasing incidence/prevalence. ...During the past 12 years, proteomics has been extensively applied to kidney stone research aiming for better under …
Nephrolithiasis/urolithiasis (i.e., kidney stone disease) remains a global public health problem with increasing incidence/pre …
Non-Coding RNAs in Kidney Stones.
Wang G, Mi J, Bai J, He Q, Li X, Wang Z. Wang G, et al. Biomolecules. 2024 Feb 11;14(2):213. doi: 10.3390/biom14020213. Biomolecules. 2024. PMID: 38397450 Free PMC article. Review.
An increasing body of evidence suggests that non-coding RNAs, especially microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), play a role in stone formation and stone-related kidney injury. MiRNAs have been studied quite extensively in nephrolithiasis, and …
An increasing body of evidence suggests that non-coding RNAs, especially microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), play a role …
Ferroptosis in calcium oxalate kidney stone formation and the possible regulatory mechanism of ANKRD1.
Zhao J, Wu Y, Zhou K, Huang M, Sun Y, Kang J, Su Q, Zhao Y, Liu Q, Li C. Zhao J, et al. Biochim Biophys Acta Mol Cell Res. 2023 Jun;1870(5):119452. doi: 10.1016/j.bbamcr.2023.119452. Epub 2023 Mar 11. Biochim Biophys Acta Mol Cell Res. 2023. PMID: 36907445 Free article.
The study found that the Nrf2/HO-1 and p53/SLC7A11 signaling pathways were activated in the kidney stone model group, and the expression of the ferroptosis marker proteins SLC7A11 and GPX4 was significantly reduced, while the expression of ACSL4 was significantly in …
The study found that the Nrf2/HO-1 and p53/SLC7A11 signaling pathways were activated in the kidney stone model group, and the …
Meta-data analysis of kidney stone disease highlights ATP1A1 involvement in renal crystal formation.
Li Y, Lu X, Yu Z, Wang H, Gao B. Li Y, et al. Redox Biol. 2023 May;61:102648. doi: 10.1016/j.redox.2023.102648. Epub 2023 Feb 27. Redox Biol. 2023. PMID: 36871182 Free PMC article.
Nephrolithiasis is a complicated disease affected by various environmental and genetic factors. Crystal-cell adhesion is a critical initiation process during kidney stone formation. However, genes regulated by environmental and genetic factors in this process …
Nephrolithiasis is a complicated disease affected by various environmental and genetic factors. Crystal-cell adhesion is a critical i …
StoneMod: a database for kidney stone modulatory proteins with experimental evidence.
Sassanarakkit S, Peerapen P, Thongboonkerd V. Sassanarakkit S, et al. Sci Rep. 2020 Sep 15;10(1):15109. doi: 10.1038/s41598-020-71730-3. Sci Rep. 2020. PMID: 32934277 Free PMC article.
Better understanding of molecular mechanisms for kidney stone formation is required to improve management of kidney stone disease with better therapeutic outcome. Recent kidney stone research has indicated critical roles of a group of pro …
Better understanding of molecular mechanisms for kidney stone formation is required to improve management of kidney
337 results