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Did you mean killen stem cell (15 results)?
Integrated pseudotime analysis of human pre-implantation embryo single-cell transcriptomes reveals the dynamics of lineage specification.
Meistermann D, Bruneau A, Loubersac S, Reignier A, Firmin J, François-Campion V, Kilens S, Lelièvre Y, Lammers J, Feyeux M, Hulin P, Nedellec S, Bretin B, Castel G, Allègre N, Covin S, Bihouée A, Soumillon M, Mikkelsen T, Barrière P, Chazaud C, Chappell J, Pasque V, Bourdon J, Fréour T, David L. Meistermann D, et al. Cell Stem Cell. 2021 Sep 2;28(9):1625-1640.e6. doi: 10.1016/j.stem.2021.04.027. Epub 2021 May 17. Cell Stem Cell. 2021. PMID: 34004179
Understanding lineage specification during human pre-implantation development is a gateway to improving assisted reproductive technologies and stem cell research. Here we employ pseudotime analysis of single-cell RNA sequencing (scRNA-seq) data to reconstruct …
Understanding lineage specification during human pre-implantation development is a gateway to improving assisted reproductive technologies a …
Induction of Human Trophoblast Stem Cells from Somatic Cells and Pluripotent Stem Cells.
Castel G, Meistermann D, Bretin B, Firmin J, Blin J, Loubersac S, Bruneau A, Chevolleau S, Kilens S, Chariau C, Gaignerie A, Francheteau Q, Kagawa H, Charpentier E, Flippe L, François-Campion V, Haider S, Dietrich B, Knöfler M, Arima T, Bourdon J, Rivron N, Masson D, Fournier T, Okae H, Fréour T, David L. Castel G, et al. Cell Rep. 2020 Nov 24;33(8):108419. doi: 10.1016/j.celrep.2020.108419. Cell Rep. 2020. PMID: 33238118 Free article.
Human trophoblast stem cells (hTSCs) derived from blastocysts and first-trimester cytotrophoblasts offer an unprecedented opportunity to study the placenta. ...Here, we show that hTSCs can be generated from numerous genetic backgrounds using post-natal cells
Human trophoblast stem cells (hTSCs) derived from blastocysts and first-trimester cytotrophoblasts offer an unprecedented oppo …
NOTO Transcription Factor Directs Human Induced Pluripotent Stem Cell-Derived Mesendoderm Progenitors to a Notochordal Fate.
Colombier P, Halgand B, Chédeville C, Chariau C, François-Campion V, Kilens S, Vedrenne N, Clouet J, David L, Guicheux J, Camus A. Colombier P, et al. Cells. 2020 Feb 24;9(2):509. doi: 10.3390/cells9020509. Cells. 2020. PMID: 32102328 Free PMC article.
After birth, mature notochordal cells (NC) are identified as key regulators of disc homeostasis. Better understanding of their biology has great potential in delaying the onset of disc degeneration or as a regenerative-cell source for disc repair. Using human plurip …
After birth, mature notochordal cells (NC) are identified as key regulators of disc homeostasis. Better understanding of their biolog …
Induction of Human Naïve Pluripotent Stem Cells from Somatic Cells.
Onfray C, Tan JP, Kilens S, Liu X, Polo J, David L. Onfray C, et al. Methods Mol Biol. 2022;2416:39-51. doi: 10.1007/978-1-0716-1908-7_4. Methods Mol Biol. 2022. PMID: 34870829
Generating patient-specific stem cells representing the onset of development has become possible since the discovery of somatic cell reprogramming into induced pluripotent stem cells. ...We also discuss validation methods for human naive pluripo …
Generating patient-specific stem cells representing the onset of development has become possible since the discovery of somati …
Parallel derivation of isogenic human primed and naive induced pluripotent stem cells.
Kilens S, Meistermann D, Moreno D, Chariau C, Gaignerie A, Reignier A, Lelièvre Y, Casanova M, Vallot C, Nedellec S, Flippe L, Firmin J, Song J, Charpentier E, Lammers J, Donnart A, Marec N, Deb W, Bihouée A, Le Caignec C, Pecqueur C, Redon R, Barrière P, Bourdon J, Pasque V, Soumillon M, Mikkelsen TS, Rougeulle C, Fréour T, David L; Milieu Intérieur Consortium. Kilens S, et al. Nat Commun. 2018 Jan 24;9(1):360. doi: 10.1038/s41467-017-02107-w. Nat Commun. 2018. PMID: 29367672 Free PMC article.
Induced pluripotent stem cells (iPSCs) have considerably impacted human developmental biology and regenerative medicine, notably because they circumvent the use of cells of embryonic origin and offer the potential to generate patient-specific pluripotent s
Induced pluripotent stem cells (iPSCs) have considerably impacted human developmental biology and regenerative medicine, notab …