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2,557 results

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Page 1
Kinesin superfamily motor proteins and intracellular transport.
Hirokawa N, Noda Y, Tanaka Y, Niwa S. Hirokawa N, et al. Nat Rev Mol Cell Biol. 2009 Oct;10(10):682-96. doi: 10.1038/nrm2774. Nat Rev Mol Cell Biol. 2009. PMID: 19773780 Review.
Intracellular transport is fundamental for cellular function, survival and morphogenesis. Kinesin superfamily proteins (also known as KIFs) are important molecular motors that directionally transport various cargos, including membranous organelles, protein complexes …
Intracellular transport is fundamental for cellular function, survival and morphogenesis. Kinesin superfamily proteins (also known as …
Structural Biology of Cilia and Intraflagellar Transport.
Klena N, Pigino G. Klena N, et al. Annu Rev Cell Dev Biol. 2022 Oct 6;38:103-123. doi: 10.1146/annurev-cellbio-120219-034238. Epub 2022 Jun 29. Annu Rev Cell Dev Biol. 2022. PMID: 35767872 Review.
In both cilia types, an intraflagellar transport (IFT) system powered by unique kinesin and dynein motors functions to deliver the molecules required to build cilia and maintain their functions. Cryo-electron tomography has helped to reveal the organization of protein c …
In both cilia types, an intraflagellar transport (IFT) system powered by unique kinesin and dynein motors functions to deliver the mo …
The intraflagellar transport cycle.
Lacey SE, Pigino G. Lacey SE, et al. Nat Rev Mol Cell Biol. 2025 Mar;26(3):175-192. doi: 10.1038/s41580-024-00797-x. Epub 2024 Nov 13. Nat Rev Mol Cell Biol. 2025. PMID: 39537792 Review.
IFT is performed by the IFT-A and IFT-B protein complexes, which together link cargoes to the microtubule motors kinesin and dynein. In this Review, we discuss recent structural and mechanistic insights on how the IFT complexes are first recruited to the base …
IFT is performed by the IFT-A and IFT-B protein complexes, which together link cargoes to the microtubule motors kinesin and d …
Kinesin-1-dependent transport of the betaPIX/GIT complex in neuronal cells.
Shin EY, Lee CS, Kim HB, Park JH, Oh K, Lee GW, Cho EY, Kim HK, Kim EG. Shin EY, et al. BMB Rep. 2021 Jul;54(7):380-385. doi: 10.5483/BMBRep.2021.54.7.061. BMB Rep. 2021. PMID: 34154701 Free PMC article.
However, the mechanism for translocation of this complex is still unknown. In the present study, we reported that the conventional kinesin, called kinesin-1, can transport the betaPIX/GIT complex. ...Furthermore, truncated mutants of betaPIX without LZ …
However, the mechanism for translocation of this complex is still unknown. In the present study, we reported that the conventional …
The gE/gI complex is necessary for kinesin-1 recruitment during alphaherpesvirus egress from neurons.
Diwaker D, Kim D, Cordova-Martinez D, Pujari N, Jordan BA, Smith GA, Wilson DW. Diwaker D, et al. J Virol. 2025 Jan 31;99(1):e0165024. doi: 10.1128/jvi.01650-24. Epub 2024 Dec 9. J Virol. 2025. PMID: 39651860 Free PMC article.
The virally encoded membrane proteins US9p and the glycoprotein heterodimer gE/gI of pseudorabies virus (PRV) and herpes simplex virus type 1 (HSV-1) play critical roles in anterograde spread, likely as a tripartite gE/gI-US9p complex. Two kinesin motors, kinesin …
The virally encoded membrane proteins US9p and the glycoprotein heterodimer gE/gI of pseudorabies virus (PRV) and herpes simplex virus type …
BORC complex specific components and Kinesin-1 mediate autophagy evasion by the autophagy-resistant Mycobacterium tuberculosis Beijing strain.
Tunganuntarat J, Kanjanasirirat P, Khumpanied T, Benjaskulluecha S, Wongprom B, Palaga T, Siregar TAP, Borwornpinyo S, Chaiprasert A, Palittapongarnpim P, Ponpuak M. Tunganuntarat J, et al. Sci Rep. 2023 Jan 30;13(1):1663. doi: 10.1038/s41598-023-28983-5. Sci Rep. 2023. PMID: 36717601 Free PMC article.
In this work, we further characterised the other specific components of the BORC complex, BORC5-8, and Kinesin proteins in autophagy resistance by the BJN. Depletion of BORCS5-8 and Kinesin-1, but not Kinesin-3, reverted autophagy avoidance by the BJN, …
In this work, we further characterised the other specific components of the BORC complex, BORC5-8, and Kinesin proteins in aut …
An orphan kinesin in Trypanosoma brucei regulates hook complex assembly and Golgi biogenesis.
Zhou Q, Kurasawa Y, Hu H, Souza Onofre T, Li Z. Zhou Q, et al. mBio. 2024 Dec 11;15(12):e0263424. doi: 10.1128/mbio.02634-24. Epub 2024 Oct 30. mBio. 2024. PMID: 39475234 Free PMC article.
The early branching kinetoplastid protozoan Trypanosoma brucei has an expanded repertoire of kinetoplastid-specific kinesins and orphan kinesins, many of which have unknown functions. We report here the identification of an orphan kinesin named KIN-G that pla …
The early branching kinetoplastid protozoan Trypanosoma brucei has an expanded repertoire of kinetoplastid-specific kinesins and orph …
The EB1-Kinesin-14 complex is required for efficient metaphase spindle assembly and kinetochore bi-orientation.
Kornakov N, Möllers B, Westermann S. Kornakov N, et al. J Cell Biol. 2020 Dec 7;219(12):e202003072. doi: 10.1083/jcb.202003072. J Cell Biol. 2020. PMID: 33044553 Free PMC article.
Here, we show that key functions of budding yeast Kinesin-14 Cik1-Kar3 are accomplished in a complex with Bim1 (yeast EB1). Genetic complementation of mitotic phenotypes identifies a novel KLTF peptide motif in the Cik1 N-terminus. ...Our results reveal the contribu …
Here, we show that key functions of budding yeast Kinesin-14 Cik1-Kar3 are accomplished in a complex with Bim1 (yeast EB1). Ge …
Dopey1-Mon2 complex binds to dual-lipids and recruits kinesin-1 for membrane trafficking.
Mahajan D, Tie HC, Chen B, Lu L. Mahajan D, et al. Nat Commun. 2019 Jul 19;10(1):3218. doi: 10.1038/s41467-019-11056-5. Nat Commun. 2019. PMID: 31324769 Free PMC article.
The N-terminus of Dopey1 further interacts with kinesin-1, a plus-end or centrifugal-direction microtubule motor. Dopey1-Mon2 complex functions as a dual-lipid-regulated cargo-adaptor to recruit kinesin-1 to secretory and endocytic organelles or membrane carr …
The N-terminus of Dopey1 further interacts with kinesin-1, a plus-end or centrifugal-direction microtubule motor. Dopey1-Mon2 comp …
Molecular basis of mRNA transport by a kinesin-1-atypical tropomyosin complex.
Dimitrova-Paternoga L, Jagtap PKA, Cyrklaff A, Vaishali, Lapouge K, Sehr P, Perez K, Heber S, Löw C, Hennig J, Ephrussi A. Dimitrova-Paternoga L, et al. Genes Dev. 2021 Jul 1;35(13-14):976-991. doi: 10.1101/gad.348443.121. Epub 2021 Jun 17. Genes Dev. 2021. PMID: 34140355 Free PMC article.
Kinesin-1 carries cargos including proteins, RNAs, vesicles, and pathogens over long distances within cells. ...Transport of oskar mRNA to the posterior pole of the Drosophila oocyte is mediated by Drosophila kinesin-1, also called kinesin heavy chain (Khc), …
Kinesin-1 carries cargos including proteins, RNAs, vesicles, and pathogens over long distances within cells. ...Transport of oskar mR …
2,557 results