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222 results

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Page 1
Clinical review: Klinefelter syndrome--a clinical update.
Groth KA, Skakkebæk A, Høst C, Gravholt CH, Bojesen A. Groth KA, et al. J Clin Endocrinol Metab. 2013 Jan;98(1):20-30. doi: 10.1210/jc.2012-2382. Epub 2012 Nov 1. J Clin Endocrinol Metab. 2013. PMID: 23118429 Review.
CONTEXT: Recently, new clinically important information regarding Klinefelter syndrome (KS) has been published. ...Medical treatment is mainly testosterone replacement therapy to alleviate acute and long-term consequences of hypogonadism as well …
CONTEXT: Recently, new clinically important information regarding Klinefelter syndrome (KS) has been published. ...Medi …
Klinefelter syndrome: etiology and clinical considerations in male infertility .
Chen X, Zhang X, Jiang T, Xu W. Chen X, et al. Biol Reprod. 2024 Sep 14;111(3):516-528. doi: 10.1093/biolre/ioae076. Biol Reprod. 2024. PMID: 38785325 Review.
Klinefelter syndrome (KS) is the most prevalent chromosomal disorder occurring in males. ...A major phenotype is impaired reproductive function, in the form of low testosterone and infertility. This review comprehensively examines the genetic and physiologica …
Klinefelter syndrome (KS) is the most prevalent chromosomal disorder occurring in males. ...A major phenotype is impaired repr …
Klinefelter's syndrome.
Lanfranco F, Kamischke A, Zitzmann M, Nieschlag E. Lanfranco F, et al. Lancet. 2004 Jul 17-23;364(9430):273-83. doi: 10.1016/S0140-6736(04)16678-6. Lancet. 2004. PMID: 15262106 Review.
Klinefelter's syndrome is the most common genetic cause of human male infertility, but many cases remain undiagnosed because of substantial variation in clinical presentation and insufficient professional awareness of the syndrome itself. …
Klinefelter's syndrome is the most common genetic cause of human male infertility, but many cases remain undiagn …
The Genetics of Female and Male Infertility.
Tüttelmann F, Wyrwoll MJ, Steingröver J, Wieacker P. Tüttelmann F, et al. Dtsch Arztebl Int. 2025 Mar 7;122(5):115-120. doi: 10.3238/arztebl.m2024.0259. Dtsch Arztebl Int. 2025. PMID: 39836465 Free PMC article. Review.
BACKGROUND: An estimated 17% of all couples worldwide are involuntarily childless (infertile). The clinically identifiable causes of infertility can be found in the male or female partner or in both. ...In men, genetic diagnosis is based primarily on the find …
BACKGROUND: An estimated 17% of all couples worldwide are involuntarily childless (infertile). The clinically identifiable causes of …
Testicular Germ Cell Tumors: A Review.
Singla N, Bagrodia A, Baraban E, Fankhauser CD, Ged YMA. Singla N, et al. JAMA. 2025 Mar 4;333(9):793-803. doi: 10.1001/jama.2024.27122. JAMA. 2025. PMID: 39899286 Review.
Risk factors include cryptorchidism, family history of testicular cancer, gonadal dysgenesis, infertility, cannabis use, and genetic conditions such as Klinefelter syndrome. The most common presenting symptom of testicular cancer is a painless testicular mass …
Risk factors include cryptorchidism, family history of testicular cancer, gonadal dysgenesis, infertility, cannabis use, and genetic …
Klinefelter Syndrome.
Kadam SJ, Leslie SW, Ford GA. Kadam SJ, et al. 2025 May 5. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. 2025 May 5. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. PMID: 29493939 Free Books & Documents.
Klinefelter syndrome is a genetic condition that affects males and is characterized by the presence of 2 or more X chromosomes. The clinical phenotype was first described in 1942 by American physician Dr. Harry Klinefelter. ...
Klinefelter syndrome is a genetic condition that affects males and is characterized by the presence of 2 or more X chromosomes …
The Klinefelter Syndrome and Testicular Sperm Retrieval Outcomes.
Sá R, Ferraz L, Barros A, Sousa M. Sá R, et al. Genes (Basel). 2023 Mar 4;14(3):647. doi: 10.3390/genes14030647. Genes (Basel). 2023. PMID: 36980920 Free PMC article. Review.
Klinefelter syndrome (KS), caused by the presence of an extra X chromosome, is the most prevalent chromosomal sexual anomaly, with an estimated incidence of 1:500/1000 per male live birth (karyotype 47,XXY). ...The retrieval of spermatozoa from the testicles …
Klinefelter syndrome (KS), caused by the presence of an extra X chromosome, is the most prevalent chromosomal sexual anomaly, …
Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells.
Zhao L, Yao C, Xing X, Jing T, Li P, Zhu Z, Yang C, Zhai J, Tian R, Chen H, Luo J, Liu N, Deng Z, Lin X, Li N, Fang J, Sun J, Wang C, Zhou Z, Li Z. Zhao L, et al. Nat Commun. 2020 Nov 10;11(1):5683. doi: 10.1038/s41467-020-19414-4. Nat Commun. 2020. PMID: 33173058 Free PMC article.
Clinical efficacy of treatments against non-obstructive azoospermia (NOA), which affects 1% of men, are currently limited by the incomplete understanding of NOA pathogenesis and normal spermatogenic microenvironment. ...Notably, Sertoli cells of patients with congen …
Clinical efficacy of treatments against non-obstructive azoospermia (NOA), which affects 1% of men, are currently limited by t …
Gonadotropin-Releasing Hormone Receptor (GnRHR) and Hypogonadotropic Hypogonadism.
Fanis P, Neocleous V, Papapetrou I, Phylactou LA, Skordis N. Fanis P, et al. Int J Mol Sci. 2023 Nov 4;24(21):15965. doi: 10.3390/ijms242115965. Int J Mol Sci. 2023. PMID: 37958948 Free PMC article. Review.
Such mutations in the GNRHR are linked to normosmic hypogonadotropic hypogonadism and lead to various clinical symptoms, including delayed puberty, infertility, and impaired sexual development. ...This comprehensive review explores GnRHR's multifaceted role in human …
Such mutations in the GNRHR are linked to normosmic hypogonadotropic hypogonadism and lead to various clinical symptoms, including de …
Klinefelter syndrome.
Smyth CM, Bremner WJ. Smyth CM, et al. Arch Intern Med. 1998 Jun 22;158(12):1309-14. doi: 10.1001/archinte.158.12.1309. Arch Intern Med. 1998. PMID: 9645824 Review.
Klinefelter syndrome is the most common sex chromosome disorder. Affected males carry an additional X chromosome, which results in male hypogonadism, androgen deficiency, and impaired spermatogenesis. ...As it affects 1 in 500 male patients and present …
Klinefelter syndrome is the most common sex chromosome disorder. Affected males carry an additional X chromosome, which result …
222 results