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Year Number of Results
1940 2
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1946 2
1947 1
1948 3
1949 7
1950 10
1951 20
1952 12
1953 25
1954 21
1955 22
1956 27
1957 18
1958 16
1959 21
1960 23
1961 28
1962 43
1963 90
1964 137
1965 103
1966 105
1967 154
1968 184
1969 199
1970 211
1971 197
1972 195
1973 179
1974 142
1975 193
1976 133
1977 111
1978 115
1979 128
1980 104
1981 112
1982 128
1983 104
1984 126
1985 130
1986 123
1987 115
1988 112
1989 106
1990 111
1991 130
1992 117
1993 120
1994 146
1995 122
1996 118
1997 141
1998 130
1999 140
2000 151
2001 145
2002 198
2003 183
2004 208
2005 204
2006 230
2007 273
2008 241
2009 275
2010 304
2011 367
2012 369
2013 467
2014 425
2015 478
2016 512
2017 542
2018 486
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2020 593
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2024 572
2025 603
2026 323

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14,378 results

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Page 1
Krebs Cycle Reborn in Macrophage Immunometabolism.
Ryan DG, O'Neill LAJ. Ryan DG, et al. Annu Rev Immunol. 2020 Apr 26;38:289-313. doi: 10.1146/annurev-immunol-081619-104850. Epub 2020 Jan 27. Annu Rev Immunol. 2020. PMID: 31986069 Review.
Perhaps surprisingly for immunologists, the Krebs cycle has emerged as the central immunometabolic hub of the macrophage. During proinflammatory macrophage activation, there is an accumulation of the Krebs cycle intermediates succinate and citrate, and …
Perhaps surprisingly for immunologists, the Krebs cycle has emerged as the central immunometabolic hub of the macrophage. Duri …
Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation.
Pålsson-McDermott EM, O'Neill LAJ. Pålsson-McDermott EM, et al. Cell Metab. 2025 May 6;37(5):1049-1059. doi: 10.1016/j.cmet.2025.03.004. Epub 2025 Mar 31. Cell Metab. 2025. PMID: 40169002 Free article. Review.
In macrophages, there has been a major focus on 3 metabolites linked to the Krebs cycle, itaconate, succinate, and fumarate, which have been shown to regulate multiple processes. ...
In macrophages, there has been a major focus on 3 metabolites linked to the Krebs cycle, itaconate, succinate, and fumarate, w …
Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers.
Murphy MP, O'Neill LAJ. Murphy MP, et al. Cell. 2018 Aug 9;174(4):780-784. doi: 10.1016/j.cell.2018.07.030. Cell. 2018. PMID: 30096309 Free article. Review.
Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. ...Succinate plays an important role in inflammatory, hypoxic, and metabolic signaling, while itaconate (from another Krebs cycle intermed …
Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. ...Succinate …
Regulation and function of the mammalian tricarboxylic acid cycle.
Arnold PK, Finley LWS. Arnold PK, et al. J Biol Chem. 2023 Feb;299(2):102838. doi: 10.1016/j.jbc.2022.102838. Epub 2022 Dec 26. J Biol Chem. 2023. PMID: 36581208 Free PMC article. Review.
The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central metabolic pathway that performs the essential function of oxidizing nutrients to support cellular bioenergetics. More recently, it has become evident that TCA cycle …
The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central metabolic pathway that perf …
Krebs cycle rewired for macrophage and dendritic cell effector functions.
Ryan DG, O'Neill LAJ. Ryan DG, et al. FEBS Lett. 2017 Oct;591(19):2992-3006. doi: 10.1002/1873-3468.12744. Epub 2017 Jul 26. FEBS Lett. 2017. PMID: 28685841 Review.
The Krebs cycle is an amphibolic pathway operating in the mitochondrial matrix of all eukaryotic organisms. ...Recently, it has been discovered that this metabolic shift also involves the rewiring of the Krebs cycle to regulate cellular metabolic flux …
The Krebs cycle is an amphibolic pathway operating in the mitochondrial matrix of all eukaryotic organisms. ...Recently, it ha …
Krebs cycle enzymes for targeted therapeutics and immunotherapy for anti-leishmanial drug development using: Pathways, potential targets, and future perspectives.
Ranjan P, Dubey VK. Ranjan P, et al. Life Sci. 2023 Jun 1;322:121314. doi: 10.1016/j.lfs.2022.121314. Epub 2022 Dec 22. Life Sci. 2023. PMID: 36566880 Review.
As a result, the drug options need to be relooked immediately. Leishmania employs Krebs cycle intermediates for its needs after infection for establishing various defense mechanisms to escape the host immune responses. ...The review brings together the available lit …
As a result, the drug options need to be relooked immediately. Leishmania employs Krebs cycle intermediates for its needs afte …
Krebs cycle intermediates regulate DNA and histone methylation: epigenetic impact on the aging process.
Salminen A, Kauppinen A, Hiltunen M, Kaarniranta K. Salminen A, et al. Ageing Res Rev. 2014 Jul;16:45-65. doi: 10.1016/j.arr.2014.05.004. Epub 2014 Jun 5. Ageing Res Rev. 2014. PMID: 24910305 Review.
Interestingly, succinate and fumarate, also Krebs cycle intermediates, are potent inhibitors of 2-OGDO enzymes, i.e. the balance of Krebs cycle reactions can affect the level of DNA and histone methylation and thus control gene expression. We will revi …
Interestingly, succinate and fumarate, also Krebs cycle intermediates, are potent inhibitors of 2-OGDO enzymes, i.e. the balan …
Genetic alterations in Krebs cycle and its impact on cancer pathogenesis.
Sajnani K, Islam F, Smith RA, Gopalan V, Lam AK. Sajnani K, et al. Biochimie. 2017 Apr;135:164-172. doi: 10.1016/j.biochi.2017.02.008. Epub 2017 Feb 20. Biochimie. 2017. PMID: 28219702 Review.
Mutations in genes encoding aconitase, isocitrate dehydrogenase, succinate dehydrogenase, fumarate hydratase, and citrate synthase are noted in many cancers. Abnormalities of Krebs cycle enzymes cause ectopic production of Krebs cycle intermediates (on …
Mutations in genes encoding aconitase, isocitrate dehydrogenase, succinate dehydrogenase, fumarate hydratase, and citrate synthase are noted …
GPR91: expanding the frontiers of Krebs cycle intermediates.
de Castro Fonseca M, Aguiar CJ, da Rocha Franco JA, Gingold RN, Leite MF. de Castro Fonseca M, et al. Cell Commun Signal. 2016 Jan 12;14:3. doi: 10.1186/s12964-016-0126-1. Cell Commun Signal. 2016. PMID: 26759054 Free PMC article. Review.
Since it was discovered, the citric acid cycle has been known to be central to cell metabolism and energy homeostasis. Mainly found in the mitochondrial matrix, some of the intermediates of the Krebs cycle are also present in the blood stream. C …
Since it was discovered, the citric acid cycle has been known to be central to cell metabolism and energy homeostasis. …
KREBS cycle.
[No authors listed] [No authors listed] Lancet. 1960 Apr 23;1(7130):907-9. Lancet. 1960. PMID: 13857525 No abstract available.
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