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Page 1
Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers.
Murphy MP, O'Neill LAJ. Murphy MP, et al. Cell. 2018 Aug 9;174(4):780-784. doi: 10.1016/j.cell.2018.07.030. Cell. 2018. PMID: 30096309 Free article. Review.
Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. ...Succinate plays an important role in inflammatory, hypoxic, and metabolic signaling, while itaconate (from another Krebs cycle intermed …
Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. ...Succinate …
Krebs cycle rewired for macrophage and dendritic cell effector functions.
Ryan DG, O'Neill LAJ. Ryan DG, et al. FEBS Lett. 2017 Oct;591(19):2992-3006. doi: 10.1002/1873-3468.12744. Epub 2017 Jul 26. FEBS Lett. 2017. PMID: 28685841 Free article. Review.
The Krebs cycle is an amphibolic pathway operating in the mitochondrial matrix of all eukaryotic organisms. ...Recently, it has been discovered that this metabolic shift also involves the rewiring of the Krebs cycle to regulate cellular metabolic flux …
The Krebs cycle is an amphibolic pathway operating in the mitochondrial matrix of all eukaryotic organisms. ...Recently, it ha …
Regulation and function of the mammalian tricarboxylic acid cycle.
Arnold PK, Finley LWS. Arnold PK, et al. J Biol Chem. 2023 Feb;299(2):102838. doi: 10.1016/j.jbc.2022.102838. Epub 2022 Dec 26. J Biol Chem. 2023. PMID: 36581208 Free PMC article. Review.
The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central metabolic pathway that performs the essential function of oxidizing nutrients to support cellular bioenergetics. More recently, it has become evident that TCA cycle …
The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central metabolic pathway that perf …
Krebs cycle enzymes for targeted therapeutics and immunotherapy for anti-leishmanial drug development using: Pathways, potential targets, and future perspectives.
Ranjan P, Dubey VK. Ranjan P, et al. Life Sci. 2023 Jun 1;322:121314. doi: 10.1016/j.lfs.2022.121314. Epub 2022 Dec 22. Life Sci. 2023. PMID: 36566880 Review.
As a result, the drug options need to be relooked immediately. Leishmania employs Krebs cycle intermediates for its needs after infection for establishing various defense mechanisms to escape the host immune responses. ...The review brings together the available lit …
As a result, the drug options need to be relooked immediately. Leishmania employs Krebs cycle intermediates for its needs afte …
Krebs and an alternative TCA cycle!
Doan MT, Teitell MA. Doan MT, et al. Cell Res. 2022 Jun;32(6):509-510. doi: 10.1038/s41422-022-00664-4. Cell Res. 2022. PMID: 35459937 Free PMC article. No abstract available.
The role of itaconate in host defense and inflammation.
Peace CG, O'Neill LA. Peace CG, et al. J Clin Invest. 2022 Jan 18;132(2):e148548. doi: 10.1172/JCI148548. J Clin Invest. 2022. PMID: 35040439 Free PMC article. Review.
This metabolic reprogramming supports phagocytic function, cytokine release, and ROS production that are critical to protective inflammatory responses. The Krebs cycle is a central metabolic pathway within all mammalian cell types. In activated macrophages, distinct …
This metabolic reprogramming supports phagocytic function, cytokine release, and ROS production that are critical to protective inflammatory …
Genetic alterations in Krebs cycle and its impact on cancer pathogenesis.
Sajnani K, Islam F, Smith RA, Gopalan V, Lam AK. Sajnani K, et al. Biochimie. 2017 Apr;135:164-172. doi: 10.1016/j.biochi.2017.02.008. Epub 2017 Feb 20. Biochimie. 2017. PMID: 28219702 Review.
Mutations in genes encoding aconitase, isocitrate dehydrogenase, succinate dehydrogenase, fumarate hydratase, and citrate synthase are noted in many cancers. Abnormalities of Krebs cycle enzymes cause ectopic production of Krebs cycle intermediates (on …
Mutations in genes encoding aconitase, isocitrate dehydrogenase, succinate dehydrogenase, fumarate hydratase, and citrate synthase are noted …
Emerging drug profile: Krebs cycle and cancer: IDH mutations and therapeutic implications.
Lee S, Urman A, Desai P. Lee S, et al. Leuk Lymphoma. 2019 Nov;60(11):2635-2645. doi: 10.1080/10428194.2019.1602260. Epub 2019 Apr 8. Leuk Lymphoma. 2019. PMID: 30958073 Review.
IDH1 and IDH2 are enzymes that are involved in the tricarboxylic acid (TCA) cycle. Activating mutations in IDH1 and IDH2 leads to increased production of 2-hydroxygluterate and epigenetic modification, affecting cell differentiation. ...
IDH1 and IDH2 are enzymes that are involved in the tricarboxylic acid (TCA) cycle. Activating mutations in IDH1 and IDH2 leads …
Queueing theory model of Krebs cycle.
Kloska S, Pałczyński K, Marciniak T, Talaśka T, Nitz M, Wysocki BJ, Davis P, Wysocki TA. Kloska S, et al. Bioinformatics. 2021 Sep 29;37(18):2912-2919. doi: 10.1093/bioinformatics/btab177. Bioinformatics. 2021. PMID: 33724355
Such a model could help to accelerate and reduce costs for developing and testing investigational drugs reducing number of laboratory animals needed to evaluate drugs. RESULTS: The article presents a Krebs cycle model based on queueing theory. The model allows for t …
Such a model could help to accelerate and reduce costs for developing and testing investigational drugs reducing number of laboratory animal …
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