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1949 18
1950 14
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1952 10
1953 20
1954 26
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1956 32
1957 32
1958 31
1959 20
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1970 258
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1997 1094
1998 1080
1999 1106
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2001 1076
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2005 1179
2006 1265
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2010 1347
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Page 1
L-glutamine for sickle cell disease: more than reducing redox.
Jafri F, Seong G, Jang T, Cimpeanu E, Poplawska M, Dutta D, Lim SH. Jafri F, et al. Ann Hematol. 2022 Aug;101(8):1645-1654. doi: 10.1007/s00277-022-04867-y. Epub 2022 May 14. Ann Hematol. 2022. PMID: 35568758 Review.
The mechanism through which L-glutamine reduces VOC in SCD is also not clear. In this paper, we will summarize the results of the Phase 3 study that led to the approval of L-glutamine for treating SCD and discuss its assumed mechanisms of action. We wi …
The mechanism through which L-glutamine reduces VOC in SCD is also not clear. In this paper, we will summarize the results of …
A Phase 3 Trial of l-Glutamine in Sickle Cell Disease.
Niihara Y, Miller ST, Kanter J, Lanzkron S, Smith WR, Hsu LL, Gordeuk VR, Viswanathan K, Sarnaik S, Osunkwo I, Guillaume E, Sadanandan S, Sieger L, Lasky JL, Panosyan EH, Blake OA, New TN, Bellevue R, Tran LT, Razon RL, Stark CW, Neumayr LD, Vichinsky EP; Investigators of the Phase 3 Trial of l-Glutamine in Sickle Cell Disease. Niihara Y, et al. N Engl J Med. 2018 Jul 19;379(3):226-235. doi: 10.1056/NEJMoa1715971. N Engl J Med. 2018. PMID: 30021096 Free article. Clinical Trial.
RESULTS: A total of 230 patients (age range, 5 to 58 years; 53.9% female) were randomly assigned, in a 2:1 ratio, to receive l-glutamine (152 patients) or placebo (78 patients). The patients in the l-glutamine group had significantly fewer pain crises …
RESULTS: A total of 230 patients (age range, 5 to 58 years; 53.9% female) were randomly assigned, in a 2:1 ratio, to receive l-glu …
L-glutamine for sickle cell disease: Knight or pawn?
Sadaf A, Quinn CT. Sadaf A, et al. Exp Biol Med (Maywood). 2020 Jan;245(2):146-154. doi: 10.1177/1535370219900637. Epub 2020 Jan 27. Exp Biol Med (Maywood). 2020. PMID: 31985279 Free PMC article. Review.
Following the FDA approval of L-glutamine for sickle cell disease, more research is still needed to understand its clinical effects and role in therapy. IMPACT STATEMENT: L-glutamine has been recently approved by the FDA for the prevention of acute com …
Following the FDA approval of L-glutamine for sickle cell disease, more research is still needed to understand its clinical ef …
L-Glutamine-, peptidyl- and protein-glutaminases: structural features and applications in the food industry.
Martínez YB, Ferreira FV, Musumeci MA. Martínez YB, et al. World J Microbiol Biotechnol. 2022 Aug 25;38(11):204. doi: 10.1007/s11274-022-03391-5. World J Microbiol Biotechnol. 2022. PMID: 36002753 Review.
However, the L-glutaminases that hydrolyze free L-glutamine (L-glutamine glutaminases, EC 3.5.1.2) have different structures and properties with respect to the L-glutaminases that hydrolyze the same amino acid covalently bound in peptides (peptidyl glu …
However, the L-glutaminases that hydrolyze free L-glutamine (L-glutamine glutaminases, EC 3.5.1.2) have differen …
The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications.
Xiao D, Zeng L, Yao K, Kong X, Wu G, Yin Y. Xiao D, et al. Amino Acids. 2016 Sep;48(9):2067-80. doi: 10.1007/s00726-016-2254-8. Epub 2016 May 9. Amino Acids. 2016. PMID: 27161106 Review.
L-Glutamine is a nutritionally semi-essential amino acid for proper growth in most cells and tissues, and plays an important role in the determination and guarding of the normal metabolic processes of the cells. With the help of transport systems, extracellular L …
L-Glutamine is a nutritionally semi-essential amino acid for proper growth in most cells and tissues, and plays an important r …
l-Glutamine for sickle cell anemia: more questions than answers.
Quinn CT. Quinn CT. Blood. 2018 Aug 16;132(7):689-693. doi: 10.1182/blood-2018-03-834440. Epub 2018 Jun 12. Blood. 2018. PMID: 29895661 Free article. Review.
In 2017, the Food and Drug Administration approved 2 medications for sickle cell anemia (SCA): hydroxyurea for children and l-glutamine for children and adults. The approval of hydroxyurea was long overdue, but the approval of l-glutamine was a surpris …
In 2017, the Food and Drug Administration approved 2 medications for sickle cell anemia (SCA): hydroxyurea for children and l-glut …
L-Glutamine in sickle cell disease.
Cox SE, Hart E, Kirkham FJ, Stotesbury H. Cox SE, et al. Drugs Today (Barc). 2020 Apr;56(4):257-268. doi: 10.1358/dot.2020.56.4.3110575. Drugs Today (Barc). 2020. PMID: 32309821
Oral L-glutamine was associated with an increase in NADH and reduction in RBC endothelium adhesion in small studies of SCD patients. In a sickle mouse model, glutamine levels were directly related to cerebral blood flow. Phase II and III randomized, double-bl …
Oral L-glutamine was associated with an increase in NADH and reduction in RBC endothelium adhesion in small studies of SCD pat …
II. Glutamine and glutamate.
Tapiero H, Mathé G, Couvreur P, Tew KD. Tapiero H, et al. Biomed Pharmacother. 2002 Nov;56(9):446-57. doi: 10.1016/s0753-3322(02)00285-8. Biomed Pharmacother. 2002. PMID: 12481981 Review.
It improves nitrogen balance and preserves the concentration of glutamine in skeletal muscle. Deamidation of glutamine via glutaminase produces glutamate a precursor of gamma-amino butyric acid, a neurotransmission inhibitor. ...Most free L-glutamic acid in brain is …
It improves nitrogen balance and preserves the concentration of glutamine in skeletal muscle. Deamidation of glutamine via glu …
The Emerging Role of l-Glutamine in Cardiovascular Health and Disease.
Durante W. Durante W. Nutrients. 2019 Sep 4;11(9):2092. doi: 10.3390/nu11092092. Nutrients. 2019. PMID: 31487814 Free PMC article. Review.
Emerging evidence indicates that l-glutamine (Gln) plays a fundamental role in cardiovascular physiology and pathology. ...
Emerging evidence indicates that l-glutamine (Gln) plays a fundamental role in cardiovascular physiology and pathology. ...
Glutamine as an immunonutrient.
Kim H. Kim H. Yonsei Med J. 2011 Nov;52(6):892-7. doi: 10.3349/ymj.2011.52.6.892. Yonsei Med J. 2011. PMID: 22028151 Free PMC article. Review.
Representative immunonutrients are arginine, omega-3 fatty acids, glutamine, nucleotides, beta-carotene, and/or branched-chain amino acids. Glutamine is the most abundant amino acid and performs multiple roles in human body. ...This review discusses the physiologica …
Representative immunonutrients are arginine, omega-3 fatty acids, glutamine, nucleotides, beta-carotene, and/or branched-chain amino …
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