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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1958 2
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1968 5
1969 9
1970 15
1971 12
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1973 12
1974 23
1975 23
1976 20
1977 24
1978 32
1979 23
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1981 33
1982 36
1983 33
1984 42
1985 44
1986 50
1987 68
1988 56
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1990 74
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1992 81
1993 92
1994 63
1995 95
1996 95
1997 102
1998 95
1999 93
2000 70
2001 87
2002 76
2003 91
2004 99
2005 88
2006 99
2007 113
2008 105
2009 96
2010 151
2011 128
2012 143
2013 150
2014 175
2015 154
2016 195
2017 202
2018 164
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2024 166
2025 238
2026 127

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5,035 results

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Page 1
Combination therapy with rifaximin and lactulose in hepatic encephalopathy: A systematic review and meta-analysis.
Fu J, Gao Y, Shi L. Fu J, et al. PLoS One. 2022 Apr 26;17(4):e0267647. doi: 10.1371/journal.pone.0267647. eCollection 2022. PLoS One. 2022. PMID: 35471992 Free PMC article.
We noted that the use of rifaximin plus lactulose was associated with an increased incidence of effective rate than lactulose alone (RR, 1.30; 95% CI, 1.10-1.53; P = 0.002). Moreover, the use of rifaximin plus lactulose was associated with a reduced risk of m …
We noted that the use of rifaximin plus lactulose was associated with an increased incidence of effective rate than lactulose …
Rifaximin plus lactulose versus lactulose alone for reducing the risk of HE recurrence.
Sanyal AJ, Kowdley KV, Reau NS, Pyrsopoulos NT, Allen C, Heimanson Z, Bajaj JS. Sanyal AJ, et al. Hepatol Commun. 2024 May 10;8(6):e0436. doi: 10.1097/HC9.0000000000000436. eCollection 2024 Jun 1. Hepatol Commun. 2024. PMID: 38727685 Free PMC article. Clinical Trial.
METHODS: Pooled post hoc subgroup analysis of adults receiving rifaximin 550 mg twice daily plus lactulose or lactulose alone for 6 months in a phase 3 randomized, double-blind trial and a phase 4 open-label trial was conducted. RESULTS AND CONCLUSION: Rifaximin plu …
METHODS: Pooled post hoc subgroup analysis of adults receiving rifaximin 550 mg twice daily plus lactulose or lactulose alone …
Lactulose: Patient- and dose-dependent prebiotic properties in humans.
Ruszkowski J, Witkowski JM. Ruszkowski J, et al. Anaerobe. 2019 Oct;59:100-106. doi: 10.1016/j.anaerobe.2019.06.002. Epub 2019 Jun 5. Anaerobe. 2019. PMID: 31176002 Review.
Lactulose is a disaccharide used in clinical practice since 1957 and has since been tested in the treatment of many human disorders, including chronic constipation, hepatic encephalopathy, and chronic kidney disease. Its mode of action is based on the lactulose ferm …
Lactulose is a disaccharide used in clinical practice since 1957 and has since been tested in the treatment of many human disorders, …
Lactulose production from lactose isomerization by chemo-catalysts and enzymes: Current status and future perspectives.
Wang M, Wang L, Lyu X, Hua X, Goddard JM, Yang R. Wang M, et al. Biotechnol Adv. 2022 Nov;60:108021. doi: 10.1016/j.biotechadv.2022.108021. Epub 2022 Jul 25. Biotechnol Adv. 2022. PMID: 35901861 Review.
Lactulose can also be produced by an enzymatic route offering a potentially greener alternative to chemo-catalysis with fewer side products. ...Finally, perspectives on challenges and opportunities in lactulose production and purification are also discussed....
Lactulose can also be produced by an enzymatic route offering a potentially greener alternative to chemo-catalysis with fewer side pr …
A randomized, double-blind, controlled trial comparing rifaximin plus lactulose with lactulose alone in treatment of overt hepatic encephalopathy.
Sharma BC, Sharma P, Lunia MK, Srivastava S, Goyal R, Sarin SK. Sharma BC, et al. Am J Gastroenterol. 2013 Sep;108(9):1458-63. doi: 10.1038/ajg.2013.219. Epub 2013 Jul 23. Am J Gastroenterol. 2013. PMID: 23877348 Clinical Trial.
Drugs used in the treatment of HE are primarily directed at the reduction of the blood ammonia levels. Rifaximin and lactulose have shown to be effective in HE. We evaluated the efficacy and safety of rifaximin plus lactulose vs. lactulose alone for treatment …
Drugs used in the treatment of HE are primarily directed at the reduction of the blood ammonia levels. Rifaximin and lactulose have s …
Lactulose--a multifaceted substance.
Huchzermeyer H, Schumann C. Huchzermeyer H, et al. Z Gastroenterol. 1997 Oct;35(10):945-55. Z Gastroenterol. 1997. PMID: 9370144 Review.
Lactulose is therapeutically used in hepatic encephalopathy, constipation, and salmonellosis. ...Lactulose presumably reduces pathogenic bacteria in favor of the health promoting bifidusflora; also, production and absorption of endotoxines may be reduced; this sugge …
Lactulose is therapeutically used in hepatic encephalopathy, constipation, and salmonellosis. ...Lactulose presumably reduces …
Lactulose: production, purification and potential applications.
Panesar PS, Kumari S. Panesar PS, et al. Biotechnol Adv. 2011 Nov-Dec;29(6):940-8. doi: 10.1016/j.biotechadv.2011.08.008. Epub 2011 Aug 12. Biotechnol Adv. 2011. PMID: 21856402 Review.
Lactulose a "bifidus factor" is composed of galactose and fructose, which can be produced by the isomerization of lactose. ...This review provides comprehensive information on the different techniques used for the production of lactulose, purification and analysis. …
Lactulose a "bifidus factor" is composed of galactose and fructose, which can be produced by the isomerization of lactose. ...This re …
Lactulose: A Simple Sugar in a Complex Encephalopathy.
Wijdicks EFM. Wijdicks EFM. Neurocrit Care. 2018 Apr;28(2):154-156. doi: 10.1007/s12028-017-0494-4. Neurocrit Care. 2018. PMID: 29297141 Review.
The discovery of lactulose, the acid dialysis proof of concept, and the role of Bircher are not well known. This historical vignette reviews the gradual understanding of the complex liver-brain connection, the effective treatment of hepatic stupor with lactulose, an …
The discovery of lactulose, the acid dialysis proof of concept, and the role of Bircher are not well known. This historical vignette …
The potential role of lactulose pharmacotherapy in the treatment and prevention of diabetes.
Chu N, Ling J, Jie H, Leung K, Poon E. Chu N, et al. Front Endocrinol (Lausanne). 2022 Sep 15;13:956203. doi: 10.3389/fendo.2022.956203. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36187096 Free PMC article. Review.
The non-absorbable disaccharide lactulose is mostly used in the treatment of various gastrointestinal disorders such as chronic constipation and hepatic encephalopathy. The mechanism of action of lactulose remains unclear, but it elicits more than osmotic laxative e …
The non-absorbable disaccharide lactulose is mostly used in the treatment of various gastrointestinal disorders such as chronic const …
Lactulose and renal failure.
Vogt B, Frey FJ. Vogt B, et al. Scand J Gastroenterol Suppl. 1997;222:100-1. doi: 10.1080/00365521.1997.11720730. Scand J Gastroenterol Suppl. 1997. PMID: 9145459 Review.
The introduction of lactulose as a new therapeutic agent for treatment of hepatic encephalopathy was a major breakthrough in this field. It was hypothesized that lactulose might prevent postoperative renal impairment after biliary surgery in patients with obstructiv …
The introduction of lactulose as a new therapeutic agent for treatment of hepatic encephalopathy was a major breakthrough in this fie …
5,035 results