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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
1993 1
2001 5
2002 2
2003 2
2004 1
2005 1
2006 3
2007 9
2008 1
2009 9
2010 4
2011 6
2012 1
2013 6
2014 10
2015 11
2016 11
2017 8
2018 6
2019 5
2020 6
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98 results
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Page 1
Hypoxia and hypoxia response-associated molecular markers in esophageal cancer: A systematic review.
Peerlings J, Van De Voorde L, Mitea C, Larue R, Yaromina A, Sandeleanu S, Spiegelberg L, Dubois L, Lambin P, Mottaghy FM. Peerlings J, et al. Methods. 2017 Nov 1;130:51-62. doi: 10.1016/j.ymeth.2017.07.002. Epub 2017 Jul 10. Methods. 2017. PMID: 28705470 Review.
Promising non-invasive imaging-techniques have been suggested to assess tumor hypoxia and hypoxia-associated molecular responses. ...For personalized hypoxia-guided treatment, safe and reliable makers for tumor hypoxia are needed to select suitable pat …
Promising non-invasive imaging-techniques have been suggested to assess tumor hypoxia and hypoxia-associated molecular respons …
Targeting Hypoxia to Improve Non-Small Cell Lung Cancer Outcome.
Salem A, Asselin MC, Reymen B, Jackson A, Lambin P, West CML, O'Connor JPB, Faivre-Finn C. Salem A, et al. J Natl Cancer Inst. 2018 Jan 1;110(1). doi: 10.1093/jnci/djx160. J Natl Cancer Inst. 2018. PMID: 28922791 Review.
Radiotherapy dose painting strategies based on hypoxia imaging require careful refinement prior to clinical investigation. This review will summarize the role of hypoxia, highlight the potential of hypoxia as a therapeutic target, and outline past and ongoing …
Radiotherapy dose painting strategies based on hypoxia imaging require careful refinement prior to clinical investigation. This revie …
Current preclinical and clinical applications of hypoxia PET imaging using 2-nitroimidazoles.
Peeters SG, Zegers CM, Yaromina A, Van Elmpt W, Dubois L, Lambin P. Peeters SG, et al. Q J Nucl Med Mol Imaging. 2015 Mar;59(1):39-57. Epub 2014 Dec 17. Q J Nucl Med Mol Imaging. 2015. PMID: 25517080 Review.
Furthermore, multiple studies describe the prognostic value of hypoxia PET imaging and the ability to monitor hypoxia during treatment. ...Also the feasibility studies for hypoxia guided intensity modulated radiation therapy and the patient stratification for …
Furthermore, multiple studies describe the prognostic value of hypoxia PET imaging and the ability to monitor hypoxia during t …
New ways to image and target tumour hypoxia and its molecular responses.
Dubois LJ, Niemans R, van Kuijk SJ, Panth KM, Parvathaneni NK, Peeters SG, Zegers CM, Rekers NH, van Gisbergen MW, Biemans R, Lieuwes NG, Spiegelberg L, Yaromina A, Winum JY, Vooijs M, Lambin P. Dubois LJ, et al. Radiother Oncol. 2015 Sep;116(3):352-7. doi: 10.1016/j.radonc.2015.08.022. Epub 2015 Aug 28. Radiother Oncol. 2015. PMID: 26324018 Free article. Review.
Tumour hypoxia and its molecular responses have been shown to be associated with poor prognosis. Detection of hypoxia, preferably in a non-invasive manner, could therefore predict treatment outcome and serve as a tool to individualize treatment. This review gives an …
Tumour hypoxia and its molecular responses have been shown to be associated with poor prognosis. Detection of hypoxia, prefera …
Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials.
Spiegelberg L, Houben R, Niemans R, de Ruysscher D, Yaromina A, Theys J, Guise CP, Smaill JB, Patterson AV, Lambin P, Dubois LJ. Spiegelberg L, et al. Clin Transl Radiat Oncol. 2019 Jan 18;15:62-69. doi: 10.1016/j.ctro.2019.01.005. eCollection 2019 Feb. Clin Transl Radiat Oncol. 2019. PMID: 30734002 Free PMC article.
The lack of stratification of patients based on tumor hypoxia status, which can vary widely, is sufficient to account for the failure of phase III trials. To fully exploit the potential of hypoxia-activated prodrugs, hypoxia stratification of patients is need …
The lack of stratification of patients based on tumor hypoxia status, which can vary widely, is sufficient to account for the failure …
Imaging of tumour hypoxia and metabolism in patients with head and neck squamous cell carcinoma.
Zegers CM, van Elmpt W, Hoebers FJ, Troost EG, Öllers MC, Mottaghy FM, Lambin P. Zegers CM, et al. Acta Oncol. 2015;54(9):1378-84. doi: 10.3109/0284186X.2015.1062913. Epub 2015 Jul 27. Acta Oncol. 2015. PMID: 26213313
BACKGROUND: Tumour hypoxia and a high tumour metabolism increase radioresistance in patients with head and neck squamous cell carcinoma (HNSCC). ...The fraction of the GTVprim with a high HX4 uptake (9 ± 10%) was on average smaller than the FDG high fraction (51 ± 26%; …
BACKGROUND: Tumour hypoxia and a high tumour metabolism increase radioresistance in patients with head and neck squamous cell carcino …
Multiparametric imaging of patient and tumour heterogeneity in non-small-cell lung cancer: quantification of tumour hypoxia, metabolism and perfusion.
van Elmpt W, Zegers CML, Reymen B, Even AJG, Dingemans AC, Oellers M, Wildberger JE, Mottaghy FM, Das M, Troost EGC, Lambin P. van Elmpt W, et al. Eur J Nucl Med Mol Imaging. 2016 Feb;43(2):240-248. doi: 10.1007/s00259-015-3169-4. Epub 2015 Sep 4. Eur J Nucl Med Mol Imaging. 2016. PMID: 26338178 Free PMC article. Clinical Trial.
Standardized uptake values (SUV) in the primary tumour were calculated for the FDG and hypoxia HX4 PET/CT scans. For hypoxia imaging, the hypoxic volume, fraction and tumour-to-blood ratio (TBR) were also defined. ...RESULTS: At the patient level, negative correlati …
Standardized uptake values (SUV) in the primary tumour were calculated for the FDG and hypoxia HX4 PET/CT scans. For hypoxia i …
Repeatability of hypoxia PET imaging using [¹⁸F]HX4 in lung and head and neck cancer patients: a prospective multicenter trial.
Zegers CM, van Elmpt W, Szardenings K, Kolb H, Waxman A, Subramaniam RM, Moon DH, Brunetti JC, Srinivas SM, Lambin P, Chien D. Zegers CM, et al. Eur J Nucl Med Mol Imaging. 2015 Nov;42(12):1840-9. doi: 10.1007/s00259-015-3100-z. Epub 2015 Jul 2. Eur J Nucl Med Mol Imaging. 2015. PMID: 26136164 Free PMC article. Clinical Trial.
PURPOSE: Hypoxia is an important factor influencing tumor progression and treatment efficacy. The aim of this study was to investigate the repeatability of hypoxia PET imaging with [(18)F]HX4 in patients with head and neck and lung cancer. ...RESULTS: All parameters …
PURPOSE: Hypoxia is an important factor influencing tumor progression and treatment efficacy. The aim of this study was to investigat …
Predicting tumor hypoxia in non-small cell lung cancer by combining CT, FDG PET and dynamic contrast-enhanced CT.
Even AJG, Reymen B, La Fontaine MD, Das M, Jochems A, Mottaghy FM, Belderbos JSA, De Ruysscher D, Lambin P, van Elmpt W. Even AJG, et al. Acta Oncol. 2017 Nov;56(11):1591-1596. doi: 10.1080/0284186X.2017.1349332. Epub 2017 Aug 25. Acta Oncol. 2017. PMID: 28840770
Hypoxia PET allows visualization of hypoxia and may enable treatment adaptation. However, hypoxia PET imaging is expensive, time-consuming and not widely available. ...CONCLUSIONS: We created a data-driven methodology to predict hypoxia levels and h …
Hypoxia PET allows visualization of hypoxia and may enable treatment adaptation. However, hypoxia PET imaging is expens …
Evofosfamide sensitizes esophageal carcinomas to radiation without increasing normal tissue toxicity.
Spiegelberg L, van Hoof SJ, Biemans R, Lieuwes NG, Marcus D, Niemans R, Theys J, Yaromina A, Lambin P, Verhaegen F, Dubois LJ. Spiegelberg L, et al. Radiother Oncol. 2019 Dec;141:247-255. doi: 10.1016/j.radonc.2019.06.034. Epub 2019 Aug 17. Radiother Oncol. 2019. PMID: 31431383 Free PMC article.
Hypoxic tumor areas cause resistance to conventional therapies, making them susceptible for treatment with hypoxia-activated prodrugs (HAPs). ...Irradiation resulted in a dose-dependent decrease of crypt survival (P < 0.001), mucosal surface area (P < 0 …
Hypoxic tumor areas cause resistance to conventional therapies, making them susceptible for treatment with hypoxia-activated prodrugs …
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