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Year Number of Results
1992 1
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110 results

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Page 1
Hypoxia and hypoxia response-associated molecular markers in esophageal cancer: A systematic review.
Peerlings J, Van De Voorde L, Mitea C, Larue R, Yaromina A, Sandeleanu S, Spiegelberg L, Dubois L, Lambin P, Mottaghy FM. Peerlings J, et al. Methods. 2017 Nov 1;130:51-62. doi: 10.1016/j.ymeth.2017.07.002. Epub 2017 Jul 10. Methods. 2017. PMID: 28705470
CONCLUSION: Evaluation of tumor micro-environmental conditions, such as intratumoral hypoxia, is important to predict treatment outcome and efficacy. Promising non-invasive imaging-techniques have been suggested to assess tumor hypoxia and hypoxia-associated …
CONCLUSION: Evaluation of tumor micro-environmental conditions, such as intratumoral hypoxia, is important to predict treatment outco …
Current preclinical and clinical applications of hypoxia PET imaging using 2-nitroimidazoles.
Peeters SG, Zegers CM, Yaromina A, Van Elmpt W, Dubois L, Lambin P. Peeters SG, et al. Q J Nucl Med Mol Imaging. 2015 Mar;59(1):39-57. Epub 2014 Dec 17. Q J Nucl Med Mol Imaging. 2015. PMID: 25517080 Review.
Multiple 2-nitroimidazole based PET tracers are developed, validated and quantified in the search for the ideal hypoxia tracer and several tracers have shown to reliably represent tumor hypoxia. Furthermore, multiple studies describe the prognostic value of hypox …
Multiple 2-nitroimidazole based PET tracers are developed, validated and quantified in the search for the ideal hypoxia tracer and se …
New ways to image and target tumour hypoxia and its molecular responses.
Dubois LJ, Niemans R, van Kuijk SJ, Panth KM, Parvathaneni NK, Peeters SG, Zegers CM, Rekers NH, van Gisbergen MW, Biemans R, Lieuwes NG, Spiegelberg L, Yaromina A, Winum JY, Vooijs M, Lambin P. Dubois LJ, et al. Radiother Oncol. 2015 Sep;116(3):352-7. doi: 10.1016/j.radonc.2015.08.022. Epub 2015 Aug 28. Radiother Oncol. 2015. PMID: 26324018 Free article. Review.
Tumour hypoxia and its molecular responses have been shown to be associated with poor prognosis. ...This review gives an overview of recent literature on hypoxia imaging markers currently used in clinical trials. Furthermore, recent progress made in targeting hyp …
Tumour hypoxia and its molecular responses have been shown to be associated with poor prognosis. ...This review gives an overview of …
FUTURE-AI: international consensus guideline for trustworthy and deployable artificial intelligence in healthcare.
Lekadir K, Frangi AF, Porras AR, Glocker B, Cintas C, Langlotz CP, Weicken E, Asselbergs FW, Prior F, Collins GS, Kaissis G, Tsakou G, Buvat I, Kalpathy-Cramer J, Mongan J, Schnabel JA, Kushibar K, Riklund K, Marias K, Amugongo LM, Fromont LA, Maier-Hein L, Cerdá-Alberich L, Martí-Bonmatí L, Cardoso MJ, Bobowicz M, Shabani M, Tsiknakis M, Zuluaga MA, Fritzsche MC, Camacho M, Linguraru MG, Wenzel M, De Bruijne M, Tolsgaard MG, Goisauf M, Cano Abadía M, Papanikolaou N, Lazrak N, Pujol O, Osuala R, Napel S, Colantonio S, Joshi S, Klein S, Aussó S, Rogers WA, Salahuddin Z, Starmans MPA; FUTURE-AI Consortium. Lekadir K, et al. BMJ. 2025 Feb 5;388:e081554. doi: 10.1136/bmj-2024-081554. BMJ. 2025. PMID: 39909534 Free PMC article.
Imaging of tumour hypoxia and metabolism in patients with head and neck squamous cell carcinoma.
Zegers CM, van Elmpt W, Hoebers FJ, Troost EG, Öllers MC, Mottaghy FM, Lambin P. Zegers CM, et al. Acta Oncol. 2015;54(9):1378-84. doi: 10.3109/0284186X.2015.1062913. Epub 2015 Jul 27. Acta Oncol. 2015. PMID: 26213313
BACKGROUND: Tumour hypoxia and a high tumour metabolism increase radioresistance in patients with head and neck squamous cell carcinoma (HNSCC). ...In the majority of lesions a partial mismatch between the [(18)F]HX4 and [(18)F]FDG high uptake volumes was observed, therefo …
BACKGROUND: Tumour hypoxia and a high tumour metabolism increase radioresistance in patients with head and neck squamous cell carcino …
Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.
Pettersen EO, Ebbesen P, Gieling RG, Williams KJ, Dubois L, Lambin P, Ward C, Meehan J, Kunkler IH, Langdon SP, Ree AH, Flatmark K, Lyng H, Calzada MJ, Peso LD, Landazuri MO, Görlach A, Flamm H, Kieninger J, Urban G, Weltin A, Singleton DC, Haider S, Buffa FM, Harris AL, Scozzafava A, Supuran CT, Moser I, Jobst G, Busk M, Toustrup K, Overgaard J, Alsner J, Pouyssegur J, Chiche J, Mazure N, Marchiq I, Parks S, Ahmed A, Ashcroft M, Pastorekova S, Cao Y, Rouschop KM, Wouters BG, Koritzinsky M, Mujcic H, Cojocari D. Pettersen EO, et al. J Enzyme Inhib Med Chem. 2015;30(5):689-721. doi: 10.3109/14756366.2014.966704. Epub 2014 Oct 27. J Enzyme Inhib Med Chem. 2015. PMID: 25347767 Free article. Review.
Low density quantitative real-time polymerase chain reaction (qPCR)-based assays were developed measuring multiple hypoxia-responsive markers in parallel to identify tumour hypoxia-related patterns of gene expression. As possible targets for new therapy two main reg …
Low density quantitative real-time polymerase chain reaction (qPCR)-based assays were developed measuring multiple hypoxia-responsive …
Targeting Hypoxia to Improve Non-Small Cell Lung Cancer Outcome.
Salem A, Asselin MC, Reymen B, Jackson A, Lambin P, West CML, O'Connor JPB, Faivre-Finn C. Salem A, et al. J Natl Cancer Inst. 2018 Jan 1;110(1). doi: 10.1093/jnci/djx160. J Natl Cancer Inst. 2018. PMID: 28922791 Review.
Radiotherapy dose painting strategies based on hypoxia imaging require careful refinement prior to clinical investigation. This review will summarize the role of hypoxia, highlight the potential of hypoxia as a therapeutic target, and outline past and ongoing …
Radiotherapy dose painting strategies based on hypoxia imaging require careful refinement prior to clinical investigation. This revie …
Development of a flexible and potent hypoxia-inducible promoter for tumor-targeted gene expression in attenuated Salmonella.
Mengesha A, Dubois L, Lambin P, Landuyt W, Chiu RK, Wouters BG, Theys J. Mengesha A, et al. Cancer Biol Ther. 2006 Sep;5(9):1120-8. doi: 10.4161/cbt.5.9.2951. Epub 2006 Sep 28. Cancer Biol Ther. 2006. PMID: 16855381 Free article.
We demonstrate that the exponential growth of the attenuated bacteria is identical under normoxia and hypoxia. A hypoxia-inducible promoter (HIP-1) was created from a portion of the endogenous Salmonella pepT promoter and was shown to drive reporter gene expression …
We demonstrate that the exponential growth of the attenuated bacteria is identical under normoxia and hypoxia. A hypoxia-induc …
Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials.
Spiegelberg L, Houben R, Niemans R, de Ruysscher D, Yaromina A, Theys J, Guise CP, Smaill JB, Patterson AV, Lambin P, Dubois LJ. Spiegelberg L, et al. Clin Transl Radiat Oncol. 2019 Jan 18;15:62-69. doi: 10.1016/j.ctro.2019.01.005. eCollection 2019 Feb. Clin Transl Radiat Oncol. 2019. PMID: 30734002 Free PMC article.
Hypoxia-activated prodrugs (HAPs) are designed to specifically target the hypoxic cells of tumors, which are an important cause of treatment resistance to conventional therapies. ...To fully exploit the potential of hypoxia-activated prodrugs, hypoxia stratif …
Hypoxia-activated prodrugs (HAPs) are designed to specifically target the hypoxic cells of tumors, which are an important cause of tr …
Mitochondrial Dysfunction Inhibits Hypoxia-Induced HIF-1alpha Stabilization and Expression of Its Downstream Targets.
van Gisbergen MW, Offermans K, Voets AM, Lieuwes NG, Biemans R, Hoffmann RF, Dubois LJ, Lambin P. van Gisbergen MW, et al. Front Oncol. 2020 May 19;10:770. doi: 10.3389/fonc.2020.00770. eCollection 2020. Front Oncol. 2020. PMID: 32509579 Free PMC article.

Increased glycolysis was observed for cytoplasmic 143B mutant hybrid (m.3243A>G, >94.5%) cells (p < 0.05) and 143B mitochondrial DNA (mtDNA) depleted cells (p < 0.05). Upon hypoxia (0.2%, 16 h), genetic or pharmacological oxidative phosphorylation (OXPHOS) inhi

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Increased glycolysis was observed for cytoplasmic 143B mutant hybrid (m.3243A>G, >94.5%) cells (p < 0.05) and 143B mitochondrial DN

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110 results