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It's a DoG-eat-DoG world-altered transcriptional mechanisms drive downstream-of-gene (DoG) transcript production.

Morgan M, Shiekhattar R, Shilatifard A, Lauberth SM. Morgan M, et al. Among authors: lauberth sm. Mol Cell. 2022 Apr 20:S1097-2765(22)00319-7. doi: 10.1016/j.molcel.2022.04.008. Online ahead of print. Mol Cell. 2022. PMID: 35487209 Review.

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Enhancer RNAs are an important regulatory layer of the epigenome.

Sartorelli V, Lauberth SM. Sartorelli V, et al. Among authors: lauberth sm. Nat Struct Mol Biol. 2020 Jun;27(6):521-528. doi: 10.1038/s41594-020-0446-0. Epub 2020 Jun 8. Nat Struct Mol Biol. 2020. PMID: 32514177 Free PMC article. Review.

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The role of enhancer RNAs in epigenetic regulation of gene expression.

Rahnamoun H, Orozco P, Lauberth SM. Rahnamoun H, et al. Among authors: lauberth sm. Transcription. 2020 Feb;11(1):19-25. doi: 10.1080/21541264.2019.1698934. Epub 2019 Dec 11. Transcription. 2020. PMID: 31823686 Free PMC article. Review.

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RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation.

Rahnamoun H, Lee J, Sun Z, Lu H, Ramsey KM, Komives EA, Lauberth SM. Rahnamoun H, et al. Among authors: lauberth sm. Nat Struct Mol Biol. 2018 Aug;25(8):687-697. doi: 10.1038/s41594-018-0102-0. Epub 2018 Aug 3. Nat Struct Mol Biol. 2018. PMID: 30076409 Free PMC article.

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Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4.

Rahnamoun H, Hong J, Sun Z, Lee J, Lu H, Lauberth SM. Rahnamoun H, et al. Among authors: lauberth sm. J Biol Chem. 2018 Aug 24;293(34):13234-13246. doi: 10.1074/jbc.RA118.003387. Epub 2018 Jun 28. J Biol Chem. 2018. PMID: 29954944 Free PMC article.

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Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling.

Rahnamoun H, Lu H, Duttke SH, Benner C, Glass CK, Lauberth SM. Rahnamoun H, et al. Among authors: lauberth sm. Nat Commun. 2017 Sep 29;8(1):754. doi: 10.1038/s41467-017-01117-y. Nat Commun. 2017. PMID: 28963538 Free PMC article.

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The basal transcription complex component TAF3 transduces changes in nuclear phosphoinositides into transcriptional output.

Stijf-Bultsma Y, Sommer L, Tauber M, Baalbaki M, Giardoglou P, Jones DR, Gelato KA, van Pelt J, Shah Z, Rahnamoun H, Toma C, Anderson KE, Hawkins P, Lauberth SM, Haramis AP, Hart D, Fischle W, Divecha N. Stijf-Bultsma Y, et al. Among authors: lauberth sm. Mol Cell. 2015 May 7;58(3):453-67. doi: 10.1016/j.molcel.2015.03.009. Epub 2015 Apr 9. Mol Cell. 2015. PMID: 25866244 Free PMC article.

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H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation.

Lauberth SM, Nakayama T, Wu X, Ferris AL, Tang Z, Hughes SH, Roeder RG. Lauberth SM, et al. Cell. 2013 Feb 28;152(5):1021-36. doi: 10.1016/j.cell.2013.01.052. Cell. 2013. PMID: 23452851 Free PMC article.

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A phosphomimetic mutation in the Sall1 repression motif disrupts recruitment of the nucleosome remodeling and deacetylase complex and repression of Gbx2.

Lauberth SM, Bilyeu AC, Firulli BA, Kroll KL, Rauchman M. Lauberth SM, et al. J Biol Chem. 2007 Nov 30;282(48):34858-68. doi: 10.1074/jbc.M703702200. Epub 2007 Sep 25. J Biol Chem. 2007. PMID: 17895244 Free article.

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A conserved 12-amino acid motif in Sall1 recruits the nucleosome remodeling and deacetylase corepressor complex.

Lauberth SM, Rauchman M. Lauberth SM, et al. J Biol Chem. 2006 Aug 18;281(33):23922-31. doi: 10.1074/jbc.M513461200. Epub 2006 May 17. J Biol Chem. 2006. PMID: 16707490 Free article.

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