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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1951 1
1952 4
1957 1
1965 2
1966 2
1967 1
1970 1
1971 7
1972 4
1973 1
1974 2
1975 2
1976 6
1977 5
1978 4
1979 6
1980 5
1981 8
1982 9
1983 11
1984 9
1985 11
1986 9
1987 9
1988 13
1989 7
1990 10
1991 8
1992 9
1993 11
1994 10
1995 11
1996 8
1997 10
1998 3
1999 15
2000 19
2001 26
2002 26
2003 27
2004 35
2005 41
2006 43
2007 37
2008 43
2009 49
2010 54
2011 75
2012 75
2013 53
2014 57
2015 75
2016 71
2017 78
2018 84
2019 113
2020 134
2021 136
2022 151
2023 157
2024 67

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1,775 results

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Page 1
The LEM-ESCRT toolkit: Repair and maintenance of the nucleus.
Borah S, Dhanasekaran K, Kumar S. Borah S, et al. Front Cell Dev Biol. 2022 Sep 12;10:989217. doi: 10.3389/fcell.2022.989217. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36172278 Free PMC article. Review.
The eukaryotic genome is enclosed in a nuclear envelope that protects it from potentially damaging cellular activities and physically segregates transcription and translation.Transport across the NE is highly regulated and occurs primarily via the macromolecular nuclear pore comp …
The eukaryotic genome is enclosed in a nuclear envelope that protects it from potentially damaging cellular activities and physically segreg …
LEM-Domain proteins: new insights into lamin-interacting proteins.
Wagner N, Krohne G. Wagner N, et al. Int Rev Cytol. 2007;261:1-46. doi: 10.1016/S0074-7696(07)61001-8. Int Rev Cytol. 2007. PMID: 17560279 Review.
LEM-domain proteins are involved in diverse cellular processes including replication and cell cycle control, chromatin organization and nuclear assembly, the regulation of gene expression and signaling pathways, as well as retroviral infection. Genetic analyses in differen …
LEM-domain proteins are involved in diverse cellular processes including replication and cell cycle control, chromatin organization a …
Networking in the nucleus: a spotlight on LEM-domain proteins.
Barton LJ, Soshnev AA, Geyer PK. Barton LJ, et al. Curr Opin Cell Biol. 2015 Jun;34:1-8. doi: 10.1016/j.ceb.2015.03.005. Epub 2015 Apr 10. Curr Opin Cell Biol. 2015. PMID: 25863918 Free PMC article. Review.
This review highlights a prominent family of nuclear lamina proteins that carries the LAP2-emerin-MAN1-domain (LEM-D). LEM-D proteins share an ability to bind lamins and tether repressive chromatin at the nuclear periphery. The importance of this family is underscor …
This review highlights a prominent family of nuclear lamina proteins that carries the LAP2-emerin-MAN1-domain (LEM-D). LEM-D p …
The nuclear envelope LEM-domain protein emerin.
Berk JM, Tifft KE, Wilson KL. Berk JM, et al. Nucleus. 2013 Jul-Aug;4(4):298-314. doi: 10.4161/nucl.25751. Epub 2013 Jul 17. Nucleus. 2013. PMID: 23873439 Free PMC article. Review.
Emerin, a conserved LEM-domain protein, is among the few nuclear membrane proteins for which extensive basic knowledge--biochemistry, partners, functions, localizations, posttranslational regulation, roles in development and links to human disease--is available. ...
Emerin, a conserved LEM-domain protein, is among the few nuclear membrane proteins for which extensive basic knowledge--biochemistry, …
Lamina-associated polypeptide (LAP)2alpha and other LEM proteins in cancer biology.
Brachner A, Foisner R. Brachner A, et al. Adv Exp Med Biol. 2014;773:143-63. doi: 10.1007/978-1-4899-8032-8_7. Adv Exp Med Biol. 2014. PMID: 24563347 Free PMC article. Review.
The LEM proteins comprise a heterogeneous family of chromatin-associated proteins that share the LEM domain, a structural motif mediating interaction with the DNA associated protein, Barrier-to-Autointegration Factor (BAF). ...A few LEM proteins, such as Lami …
The LEM proteins comprise a heterogeneous family of chromatin-associated proteins that share the LEM domain, a structural moti …
Evolvement of LEM proteins as chromatin tethers at the nuclear periphery.
Brachner A, Foisner R. Brachner A, et al. Biochem Soc Trans. 2011 Dec;39(6):1735-41. doi: 10.1042/BST20110724. Biochem Soc Trans. 2011. PMID: 22103517 Free PMC article. Review.
They contain a common structural, bihelical motif, the so-called LEM domain, which mediates binding to a conserved chromatin protein, BAF (barrier to autointegration factor). ...In addition, we discuss the potential evolution of HeH/SAP and LEM domain-containing pro …
They contain a common structural, bihelical motif, the so-called LEM domain, which mediates binding to a conserved chromatin protein, …
Beyond Tethering and the LEM domain: MSCellaneous functions of the inner nuclear membrane Lem2.
Braun S, Barrales RR. Braun S, et al. Nucleus. 2016 Nov;7(6):523-531. doi: 10.1080/19491034.2016.1252892. Epub 2016 Oct 31. Nucleus. 2016. PMID: 27797637 Free PMC article. Review.
Various inner nuclear membrane (INM) proteins associate with transcriptionally repressed chromatin, which is often found at the nuclear periphery. A prominent example is the conserved family of LEM (LAP2-Emerin-MAN1) domain proteins that interact with DNA-binding proteins …
Various inner nuclear membrane (INM) proteins associate with transcriptionally repressed chromatin, which is often found at the nuclear peri …
Nuclear envelope assembly relies on CHMP-7 in the absence of BAF-LEM-mediated hole closure.
Barger SR, Penfield L, Bahmanyar S. Barger SR, et al. J Cell Sci. 2023 Nov 1;136(21):jcs261385. doi: 10.1242/jcs.261385. Epub 2023 Nov 13. J Cell Sci. 2023. PMID: 37795681 Free PMC article.
BAF binds LEM-domain family proteins to repair NE ruptures in interphase, but whether BAF-LEM binding participates in NE hole closure around spindle MTs is not known. ...In the absence of BAF-LEM binding, LEM-2-CHMP-7 was required for NE assembly and e …
BAF binds LEM-domain family proteins to repair NE ruptures in interphase, but whether BAF-LEM binding participates in NE hole …
[Structure and biological functions of mammalian LEM-domain proteins].
Hu QX, Gao A, Zeng WJ, Wang YX, Dong JT, Zhu ZM. Hu QX, et al. Yi Chuan. 2015 Feb;37(2):128-139. doi: 10.16288/j.yczz.14-351. Yi Chuan. 2015. PMID: 25665639 Review. Chinese.
The structure and function of the ternary complex formed by LEM-domain protein, nuclear lamina protein and BAF are dependent on each other. ...This review provides a detailed summary of structural and functional studies of the LEM family proteins....
The structure and function of the ternary complex formed by LEM-domain protein, nuclear lamina protein and BAF are dependent on each …
LEM Domain Containing 1 Acts as a Novel Oncogene and Therapeutic Target for Triple-Negative Breast Cancer.
Li X, Jiang S, Jiang T, Sun X, Guan Y, Fan S, Cheng Y. Li X, et al. Cancers (Basel). 2023 May 26;15(11):2924. doi: 10.3390/cancers15112924. Cancers (Basel). 2023. PMID: 37296887 Free PMC article.
Exploring novel therapeutic targets holds promise for developing effective treatments for TNBC. Here, we demonstrated for the first time that LEMD1 (LEM domain containing 1) is highly expressed in TNBC and contributes to reduced survival in TNBC patients, through analysis …
Exploring novel therapeutic targets holds promise for developing effective treatments for TNBC. Here, we demonstrated for the first time tha …
1,775 results

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