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Year Number of Results
1970 2
1971 4
1972 1
1973 4
1974 1
1976 10
1977 4
1978 3
1979 4
1980 12
1981 9
1982 19
1983 10
1984 13
1985 11
1986 12
1987 19
1988 23
1989 21
1990 23
1991 7
1992 19
1993 12
1994 19
1995 11
1996 13
1997 11
1998 9
1999 12
2000 10
2001 5
2002 11
2003 14
2004 13
2005 11
2006 11
2007 6
2008 12
2009 19
2010 21
2011 17
2012 17
2013 17
2014 16
2015 15
2016 17
2017 20
2018 29
2019 25
2020 36
2021 19
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644 results
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Mushroom polysaccharide lentinan for treating different types of cancers: A review of 12 years clinical studies in China.
Zhang M, Zhang Y, Zhang L, Tian Q. Zhang M, et al. Prog Mol Biol Transl Sci. 2019;163:297-328. doi: 10.1016/bs.pmbts.2019.02.013. Epub 2019 Apr 4. Prog Mol Biol Transl Sci. 2019. PMID: 31030752 Review.
It is the second largest cultivated and the most popular edible mushroom in the world known as "Xianggu" in China and "Shiitake" in Japan. Lentinan is a polysaccharide extracted from Lentinula edodes. beta-Glucan is the major bioactive component in lentinan with imm …
It is the second largest cultivated and the most popular edible mushroom in the world known as "Xianggu" in China and "Shiitake" in Japan. …
Lentinan as an immunotherapeutic for treating lung cancer: a review of 12 years clinical studies in China.
Zhang Y, Zhang M, Jiang Y, Li X, He Y, Zeng P, Guo Z, Chang Y, Luo H, Liu Y, Hao C, Wang H, Zhang G, Zhang L. Zhang Y, et al. J Cancer Res Clin Oncol. 2018 Nov;144(11):2177-2186. doi: 10.1007/s00432-018-2718-1. Epub 2018 Jul 24. J Cancer Res Clin Oncol. 2018. PMID: 30043277 Review.
PURPOSE: Lentinan is a polysaccharide extracted from Shiitake mushrooms that have been used to improve general health for thousands of years in Asia. Lentinan injection is a clinically approved drug in several countries in Asia. ...
PURPOSE: Lentinan is a polysaccharide extracted from Shiitake mushrooms that have been used to improve general health for thousands o …
Quality control and immunological activity of lentinan samples produced in China.
Wang Y, Jin H, Yu J, Qu C, Wang Q, Yang S, Ma S, Ni J. Wang Y, et al. Int J Biol Macromol. 2020 Sep 15;159:129-136. doi: 10.1016/j.ijbiomac.2020.05.050. Epub 2020 May 12. Int J Biol Macromol. 2020. PMID: 32407945
The chemical structure of lentinan is highly associated with its biological activity. In this study, the correlation between the structure of lentinan and its immune activity was investigated to assess the function of key parameters that can influence quality contro …
The chemical structure of lentinan is highly associated with its biological activity. In this study, the correlation between the stru …
Intrathoracic infusion therapy with Lentinan and chemical irritants for malignant pleural effusion: a systematic review and meta-analysis of 65 randomized controlled trials.
Xiao Z, Jiang Y, Chen XF, Wang CQ, Zheng XT, Xu WH, Zou XX, Zhou JM, Yang YH, Hu SS, Shan LJ, Cai QY, Tang YH, Feng JH, Xiao X. Xiao Z, et al. Phytomedicine. 2020 Jun 1;76:153260. doi: 10.1016/j.phymed.2020.153260. Online ahead of print. Phytomedicine. 2020. PMID: 32535483 Review.
BACKGROUND: Aderivative of Shiitake mushrooms, Lentinan is used to control malignant pleural effusion (MPE) through intrathoracic infusion. ...METHODS: We collected all randomized controlled trials (RCTs) regarding Lentinan plus chemical irritants from Chinese and E …
BACKGROUND: Aderivative of Shiitake mushrooms, Lentinan is used to control malignant pleural effusion (MPE) through intrathoracic inf …
Selenium-lentinan inhibits tumor progression by regulating epithelial-mesenchymal transition.
Liu YR, Sun B, Zhu GH, Li WW, Tian YX, Wang LM, Zong SM, Sheng PZ, Li M, Chen S, Qin Y, Liu HJ, Zhou HG, Sun T, Yang C. Liu YR, et al. Toxicol Appl Pharmacol. 2018 Dec 1;360:1-8. doi: 10.1016/j.taap.2018.09.019. Epub 2018 Sep 18. Toxicol Appl Pharmacol. 2018. PMID: 30240696
METHODS: Lentinan, an antitumor polysaccharide extracted from Lentinus edodes, was conjugated with seleninic acid to be transformed into ester (Se-lentinan) and utilized as drug carrier. ...RESULTS: Se-lentinan inhibited the invasiveness of B16-BL6 and HCT-8 …
METHODS: Lentinan, an antitumor polysaccharide extracted from Lentinus edodes, was conjugated with seleninic acid to be transformed i …
Lentinan Inhibits AGE-Induced Inflammation and the Expression of Matrix-Degrading Enzymes in Human Chondrocytes.
Zhang Z, Zha Z, Zhao Z, Liu W, Li W. Zhang Z, et al. Drug Des Devel Ther. 2020 Jul 17;14:2819-2829. doi: 10.2147/DDDT.S243311. eCollection 2020. Drug Des Devel Ther. 2020. PMID: 32764881 Free PMC article.
Lentinan also reduces AGE-induced increased expression of matrix metalloproteinases-1, -3, and -13 (MMP-1, MMP-3, MMP-13). ...Mechanistically, lentinan reduces the activation of NF-kappaB. CONCLUSION: Our findings indicate that lentinan shows a protective eff
Lentinan also reduces AGE-induced increased expression of matrix metalloproteinases-1, -3, and -13 (MMP-1, MMP-3, MMP-13). ...Mechani
Lentinan inhibits oxidative stress and inflammatory cytokine production induced by benzo(a)pyrene in human keratinocytes.
Zi Y, Jiang B, He C, Liu L. Zi Y, et al. J Cosmet Dermatol. 2020 Feb;19(2):502-507. doi: 10.1111/jocd.13005. Epub 2019 May 28. J Cosmet Dermatol. 2020. PMID: 31135098
However, the effect of lentinan on human keratinocytes treated with benzo(a)pyrene is unknown. ...In addition, malondialdehyde levels were reduced to 53% of those of cells treated with benzo(a)pyrene without lentinan. The activities of superoxide dismutase and gluta …
However, the effect of lentinan on human keratinocytes treated with benzo(a)pyrene is unknown. ...In addition, malondialdehyde levels …
Lentinan improved the efficacy of vaccine against Trichinella spiralis in an NLRP3 dependent manner.
Jin X, Liu X, Ding J, Zhang L, Yang Y, Wang X, Yang Y, Liu M. Jin X, et al. PLoS Negl Trop Dis. 2020 Sep 25;14(9):e0008632. doi: 10.1371/journal.pntd.0008632. eCollection 2020 Sep. PLoS Negl Trop Dis. 2020. PMID: 32976511 Free PMC article.
The reduction rate of helminth burden of rTs-Serpin+lentinan-immunized mice was significantly increased compared with rTs-Serpin+FCA -immunized mice. rTs-Serpin+lentinan induced IgG1-dominant immune response and higher levels of IFN-gamma and IL-4. rTs-Serpin+len
The reduction rate of helminth burden of rTs-Serpin+lentinan-immunized mice was significantly increased compared with rTs-Serpin+FCA …
Lentinan protects cardiomyocytes against hypoxia-induced injury by regulation of microRNA-22/Sirt1.
Zhang S, Zhao Y. Zhang S, et al. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3938-3946. doi: 10.1080/21691401.2019.1666863. Artif Cells Nanomed Biotechnol. 2019. PMID: 31581847
Myocardial ischemia is a serious disease which threatens human's life. Lentinan (LEN) possesses multiple biological properties: anticancer, antibacterial, antiviral and antioxidant effects. ...In conclusion, LEN relieved hypoxia-induced cellular injuries evidenced by incre …
Myocardial ischemia is a serious disease which threatens human's life. Lentinan (LEN) possesses multiple biological properties: antic …
Effects of lentinan on NF-kappaB activity in the liver of burn rats with sepsis.
Lv Q, Gu Y, Qi Y, Liu Z, Ma GE. Lv Q, et al. Exp Ther Med. 2020 Sep;20(3):2279-2283. doi: 10.3892/etm.2020.8955. Epub 2020 Jun 29. Exp Ther Med. 2020. PMID: 32765705 Free PMC article.
Effects of lentinan on nuclear factor-kappaB (NF-kappaB) activity in liver of burn rats with sepsis were investigated. ...Seventy-two adult rats were randomly divided into six groups: the normal control group (n=12); the burn sepsis group (n=12); the burn sepsis with posit …
Effects of lentinan on nuclear factor-kappaB (NF-kappaB) activity in liver of burn rats with sepsis were investigated. ...Seventy-two …
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