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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 3
1992 1
1993 3
1994 7
1995 11
1996 4
1997 4
1998 13
1999 24
2000 31
2001 30
2002 40
2003 40
2004 55
2005 53
2006 50
2007 42
2008 47
2009 34
2010 26
2011 36
2012 28
2013 21
2014 14
2015 10
2016 6
2017 8
2018 8
2019 13
2020 7
2021 4
2022 6
2023 6
2024 3

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644 results

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Page 1
Lepirudin.
[No authors listed] [No authors listed] 2023 Jul 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2023 Jul 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000058 Free Books & Documents. Review.
Lepirudin is no longer marketed in the United States. Limited information indicates that lepirudin in doses up to 100 mg daily produce very low levels in milk. Because of its large molecular weight, it would not be expected to be absorbed from breastmilk by the infa …
Lepirudin is no longer marketed in the United States. Limited information indicates that lepirudin in doses up to 100 mg daily …
Ecarin based coagulation testing.
Gosselin RC, Douxfils J. Gosselin RC, et al. Am J Hematol. 2020 Jul;95(7):863-869. doi: 10.1002/ajh.25852. Epub 2020 May 30. Am J Hematol. 2020. PMID: 32350907 Free article. Review.
This test was initially described for the assessment of direct thrombin inhibitors (eg, bivalirudin lepirudin, or argatroban) and was not affected by heparins or heparinoids. ...
This test was initially described for the assessment of direct thrombin inhibitors (eg, bivalirudin lepirudin, or argatroban) and was …
Think of HIT.
Warkentin TE. Warkentin TE. Hematology Am Soc Hematol Educ Program. 2006:408-14. doi: 10.1182/asheducation-2006.1.408. Hematology Am Soc Hematol Educ Program. 2006. PMID: 17124091 Review.
Thus, it is important to avoid or postpone coumarin while managing HIT hypercoagulability, focusing on agents that inhibit thrombin directly (lepirudin, argatroban) or that inhibit its generation (danaparoid, fondaparinux). Post-marketing experience suggests that standard …
Thus, it is important to avoid or postpone coumarin while managing HIT hypercoagulability, focusing on agents that inhibit thrombin directly …
Heparin-induced thrombocytopenia.
Szokol JW. Szokol JW. Semin Cardiothorac Vasc Anesth. 2010 Mar;14(1):73-4. doi: 10.1177/1089253210362795. Semin Cardiothorac Vasc Anesth. 2010. PMID: 20472634
For patients presenting for cardiac surgery and cardiopulmonary bypass that have a history of HIT and positive antibodies a direct thrombin inhibitor such as lepirudin, argatroban or bivalirudin must be used in lieu of heparin....
For patients presenting for cardiac surgery and cardiopulmonary bypass that have a history of HIT and positive antibodies a direct thrombin …
Heparin induced thrombocytopenia: review.
Dasararaju R, Singh N, Mehta A. Dasararaju R, et al. Expert Rev Hematol. 2013 Aug;6(4):419-28. doi: 10.1586/17474086.2013.814446. Expert Rev Hematol. 2013. PMID: 23991928 Review.
Score < 3 is highly specific to exclude the diagnosis. Alternate anticoagulants like lepirudin, argatroban or danaparoid are recommended in therapeutic dose to treat or prevent thrombotic events in HIT. ...

Score < 3 is highly specific to exclude the diagnosis. Alternate anticoagulants like lepirudin, argatroban or danaparoid are recom

…
Emerging anticoagulants.
Kennedy B, Gargoum FS, Kennedy L, Khan F, Curran DR, O'Connor TM. Kennedy B, et al. Curr Med Chem. 2012;19(20):3388-416. doi: 10.2174/092986712801215847. Curr Med Chem. 2012. PMID: 22680641 Review.
Direct thrombin inhibitors (factor IIa inhibitors) were developed with the limitations of standard heparin and warfarin in mind. Examples include recombinant hirudin (lepirudin), bivalirudin, ximelagatran, argatroban, and dabigatran etexilate. ...
Direct thrombin inhibitors (factor IIa inhibitors) were developed with the limitations of standard heparin and warfarin in mind. Examples in …
Direct thrombin inhibitors.
Lee CJ, Ansell JE. Lee CJ, et al. Br J Clin Pharmacol. 2011 Oct;72(4):581-92. doi: 10.1111/j.1365-2125.2011.03916.x. Br J Clin Pharmacol. 2011. PMID: 21241354 Free PMC article. Review.
Currently, four parenteral direct inhibitors of thrombin activity are FDA-approved in North America: lepirudin, desirudin, bivalirudin and argatroban. Of the new oral DTIs, dabigatran etexilate is the most studied and promising of these agents. ...
Currently, four parenteral direct inhibitors of thrombin activity are FDA-approved in North America: lepirudin, desirudin, bivalirudi …
Removal of lepirudin, a recombinant hirudin, by hemodialysis, hemofiltration, or plasmapheresis.
Willey ML, de Denus S, Spinler SA. Willey ML, et al. Pharmacotherapy. 2002 Apr;22(4):492-9. doi: 10.1592/phco.22.7.492.33671. Pharmacotherapy. 2002. PMID: 11939684 Review.
However, because it is eliminated by the kidneys, the half-life of lepirudin may be substantially prolonged in patients with renal failure. ...Understanding the effects of hemodialysis, hemofiltration, and plasmapheresis on lepirudin levels is important, especially …
However, because it is eliminated by the kidneys, the half-life of lepirudin may be substantially prolonged in patients with renal fa …
[Heparin-induced thrombocytopenia].
Thiele T, Althaus K, Greinacher A. Thiele T, et al. Internist (Berl). 2010 Sep;51(9):1127-32, 1134-5. doi: 10.1007/s00108-010-2594-5. Internist (Berl). 2010. PMID: 20694716 Review. German.
The drugs currently available for this include the direct thrombin inhibitors argatroban, lepirudin, bivalirudin, and desirudin and the indirect factor Xa inhibitors danaparoid and fondaparinux....
The drugs currently available for this include the direct thrombin inhibitors argatroban, lepirudin, bivalirudin, and desirudin and t …
Direct thrombin inhibitors.
Kaplan KL, Francis CW. Kaplan KL, et al. Semin Hematol. 2002 Jul;39(3):187-96. doi: 10.1053/shem.2002.34092. Semin Hematol. 2002. PMID: 12124681 Review.
There are three direct thrombin inhibitors approved for clinical use at present (lepirudin, bivalirudin, argatroban) and another in advanced clinical testing (melagatran/ximelagatran). ...
There are three direct thrombin inhibitors approved for clinical use at present (lepirudin, bivalirudin, argatroban) and another in a …
644 results