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Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis.
De Rosa V, Procaccini C, La Cava A, Chieffi P, Nicoletti GF, Fontana S, Zappacosta S, Matarese G. De Rosa V, et al. J Clin Invest. 2006 Feb;116(2):447-55. doi: 10.1172/JCI26523. Epub 2006 Jan 12. J Clin Invest. 2006. PMID: 16410832 Free PMC article.
This was also confirmed by induction of forkhead box p3 (Foxp3) expression in CD4 T cells in leptin-neutralized mice. Importantly, anti-leptin treatment induced a failure to downmodulate the cyclin-dependent kinase inhibitor p27 (p27) in autoreactive CD4 T ce …
This was also confirmed by induction of forkhead box p3 (Foxp3) expression in CD4 T cells in leptin-neutralized mice. Importan …
Leptin blocks the inhibitory effect of vitamin D on adipogenesis and cell proliferation in 3T3-L1 adipocytes.
Nobre JL, Lisboa PC, Carvalho JC, Martins MR, Vargas S, Barja-Fidalgo C, de Moura EG, de Oliveira E. Nobre JL, et al. Gen Comp Endocrinol. 2018 Sep 15;266:1-8. doi: 10.1016/j.ygcen.2018.01.014. Epub 2018 Jan 12. Gen Comp Endocrinol. 2018. PMID: 29339180
Recently, we demonstrated high serum leptin and 25(OH)D (calcidiol) in obese animals, with high C/EBP(beta) and PPAR(gamma) expression in adipose tissue. Since the role of vitamin D in adipogenesis remains controversial and hyperleptinemia is found in obesity, we asked if …
Recently, we demonstrated high serum leptin and 25(OH)D (calcidiol) in obese animals, with high C/EBP(beta) and PPAR(gamma) expressio …
Leptin promotes human endometriotic cell migration and invasion by up-regulating MMP-2 through the JAK2/STAT3 signaling pathway.
Ahn JH, Choi YS, Choi JH. Ahn JH, et al. Mol Hum Reprod. 2015 Oct;21(10):792-802. doi: 10.1093/molehr/gav039. Epub 2015 Jul 7. Mol Hum Reprod. 2015. PMID: 26153131
Leptin receptor (ObR) siRNA significantly inhibited the migration and invasion induced by leptin in 11Z and 12Z cells. ...Janus Kinase 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) inhibitor (AG490) significantly inhibited the migration, invasion …
Leptin receptor (ObR) siRNA significantly inhibited the migration and invasion induced by leptin in 11Z and 12Z cells. ...Janu …
Hepatitis C virus core protein stimulates fibrogenesis in hepatic stellate cells involving the obese receptor.
Wu CF, Lin YL, Huang YT. Wu CF, et al. J Cell Biochem. 2013 Mar;114(3):541-50. doi: 10.1002/jcb.24392. J Cell Biochem. 2013. PMID: 22961938
HCVcp induced mRNA and protein expression of ObR. Blocking of Ob-Rb with a neutralizing antibody inhibited phosphorylation of signal transducer and activator of transcription 3 (STAT3) and AMPKalpha stimulated by HCVcp. ...
HCVcp induced mRNA and protein expression of ObR. Blocking of Ob-Rb with a neutralizing antibody inhibited phosphorylation of signal …
Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2.
Chan YC, Roy S, Khanna S, Sen CK. Chan YC, et al. Arterioscler Thromb Vasc Biol. 2012 Jun;32(6):1372-82. doi: 10.1161/ATVBAHA.112.248583. Epub 2012 Apr 12. Arterioscler Thromb Vasc Biol. 2012. PMID: 22499991 Free PMC article.
These outcomes were attenuated using anti-miR-200b strategy. Neutralization of tumor necrosis factor-alpha in the diabetic wounds improved wound angiogenesis and closure, which was accompanied by downregulation of miR-200b expression and desilencing of GATA2 and VEGFR2. .. …
These outcomes were attenuated using anti-miR-200b strategy. Neutralization of tumor necrosis factor-alpha in the diabetic wounds imp …