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32 results

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Page 1
Novel seizure phenotype and sleep disruptions in knock-in mice with hypersensitive alpha 4* nicotinic receptors.
Fonck C, Cohen BN, Nashmi R, Whiteaker P, Wagenaar DA, Rodrigues-Pinguet N, Deshpande P, McKinney S, Kwoh S, Munoz J, Labarca C, Collins AC, Marks MJ, Lester HA. Fonck C, et al. Among authors: lester ha. J Neurosci. 2005 Dec 7;25(49):11396-411. doi: 10.1523/JNEUROSCI.3597-05.2005. J Neurosci. 2005. PMID: 16339034 Free PMC article.
Expressed in Xenopus oocytes, alpha4(L9'A)beta2 nAChRs were > or =30-fold more sensitive than wild type (WT) to both ACh and nicotine. We generated knock-in mice with the L9'A mutation and studied their cellular responses, seizure phenotype, and sleep-wake cycle. …
Expressed in Xenopus oocytes, alpha4(L9'A)beta2 nAChRs were > or =30-fold more sensitive than wild type (WT) to both ACh and nicotine. We …
TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus.
Hurtado-Zavala JI, Ramachandran B, Ahmed S, Halder R, Bolleyer C, Awasthi A, Stahlberg MA, Wagener RJ, Anderson K, Drenan RM, Lester HA, Miwa JM, Staiger JF, Fischer A, Dean C. Hurtado-Zavala JI, et al. Among authors: lester ha. Nat Commun. 2017 Jul 19;8:15878. doi: 10.1038/ncomms15878. Nat Commun. 2017. PMID: 28722015 Free PMC article.
We found that TRPV1 is expressed in oriens-lacunosum-moleculare (OLM) interneurons in the hippocampus, and promotes excitatory innervation. TRPV1 knockout mice have reduced glutamatergic innervation of OLM neurons. When activated by capsaicin, TRPV1 recruits more glutamate …
We found that TRPV1 is expressed in oriens-lacunosum-moleculare (OLM) interneurons in the hippocampus, and promotes excitatory innervation. …
Insights into the neurobiology of the nicotinic cholinergic system and nicotine addiction from mice expressing nicotinic receptors harboring gain-of-function mutations.
Drenan RM, Lester HA. Drenan RM, et al. Among authors: lester ha. Pharmacol Rev. 2012 Oct;64(4):869-79. doi: 10.1124/pr.111.004671. Epub 2012 Aug 10. Pharmacol Rev. 2012. PMID: 22885704 Free PMC article. Review.
Gain-of-function mutations, including those in nAChR subunits, provide an approach that is complementary to loss-of-function studies such as gene knockouts; the former allows one to answer questions of sufficiency and the latter addresses questions of necessity. ...
Gain-of-function mutations, including those in nAChR subunits, provide an approach that is complementary to loss-of-function studies such as …
Nicotine responses in hypersensitive and knockout alpha 4 mice account for tolerance to both hypothermia and locomotor suppression in wild-type mice.
Tapper AR, McKinney SL, Marks MJ, Lester HA. Tapper AR, et al. Among authors: lester ha. Physiol Genomics. 2007 Nov 14;31(3):422-8. doi: 10.1152/physiolgenomics.00063.2007. Epub 2007 Aug 21. Physiol Genomics. 2007. PMID: 17712039
To evaluate the contribution of alpha 4* and non-alpha 4 nAChRs in the development of tolerance to hypothermia and locomotor suppression, alpha 4 knockout (KO), hypersensitive Leu9'Ala alpha 4 knock-in, and wild-type (WT) mice received daily nicotine injectio …
To evaluate the contribution of alpha 4* and non-alpha 4 nAChRs in the development of tolerance to hypothermia and locomotor suppression, al …
Increased sensitivity to agonist-induced seizures, straub tail, and hippocampal theta rhythm in knock-in mice carrying hypersensitive alpha 4 nicotinic receptors.
Fonck C, Nashmi R, Deshpande P, Damaj MI, Marks MJ, Riedel A, Schwarz J, Collins AC, Labarca C, Lester HA. Fonck C, et al. Among authors: lester ha. J Neurosci. 2003 Apr 1;23(7):2582-90. doi: 10.1523/JNEUROSCI.23-07-02582.2003. J Neurosci. 2003. PMID: 12684443 Free PMC article.
We studied a strain of exon replacement mice ("L9'S knock-in") whose alpha4 nicotinic receptor subunits have a leucine to serine mutation in the M2 region, 9' position (Labarca et al., 2001); this mutation renders alpha4-containing receptors hypersensitive to agonis …
We studied a strain of exon replacement mice ("L9'S knock-in") whose alpha4 nicotinic receptor subunits have a leucine to seri …
Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm.
Shao XM, Tan W, Xiu J, Puskar N, Fonck C, Lester HA, Feldman JL. Shao XM, et al. Among authors: lester ha. J Neurosci. 2008 Jan 9;28(2):519-28. doi: 10.1523/JNEUROSCI.3666-07.2008. J Neurosci. 2008. PMID: 18184794 Free PMC article.
To further explore the molecular composition of these nAChRs, we studied a knock-in mouse strain with a leucine-to-alanine mutation in the M2 pore-lining region (L9'A) of the nAChR alpha4 subunit; this mutation renders alpha4-containing receptors hypersensitive to a …
To further explore the molecular composition of these nAChRs, we studied a knock-in mouse strain with a leucine-to-alanine mut …
Deletion of lynx1 reduces the function of α6* nicotinic receptors.
Parker RL, O'Neill HC, Henley BM, Wageman CR, Drenan RM, Marks MJ, Miwa JM, Grady SR, Lester HA. Parker RL, et al. Among authors: lester ha. PLoS One. 2017 Dec 5;12(12):e0188715. doi: 10.1371/journal.pone.0188715. eCollection 2017. PLoS One. 2017. PMID: 29206881 Free PMC article.
To test whether lynx1 is important for the function of alpha6 nAChRs in vivo, we bred transgenic mice carrying a hypersensitive mutation in the alpha6 nAChR subunit (alpha6L9'S) with lynx1 knockout mice, providing a selective probe of the effects of lynx1 on alpha6* nAChRs …
To test whether lynx1 is important for the function of alpha6 nAChRs in vivo, we bred transgenic mice carrying a hypersensitive mutation in …
Differential expression and function of nicotinic acetylcholine receptors in subdivisions of medial habenula.
Shih PY, Engle SE, Oh G, Deshpande P, Puskar NL, Lester HA, Drenan RM. Shih PY, et al. Among authors: lester ha. J Neurosci. 2014 Jul 16;34(29):9789-802. doi: 10.1523/JNEUROSCI.0476-14.2014. J Neurosci. 2014. PMID: 25031416 Free PMC article.
In this paper, we report new details regarding nAChR anatomical localization and function in MHb and IPN. A new group of knock-in mice were created that each expresses a single nAChR subunit fused to GFP, allowing high-resolution mapping. ...
In this paper, we report new details regarding nAChR anatomical localization and function in MHb and IPN. A new group of knock-in …
Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.
O'Neill HC, Laverty DC, Patzlaff NE, Cohen BN, Fonck C, McKinney S, McIntosh JM, Lindstrom JM, Lester HA, Grady SR, Marks MJ. O'Neill HC, et al. Among authors: lester ha. Pharmacol Biochem Behav. 2013 Jan;103(3):603-21. doi: 10.1016/j.pbb.2012.10.014. Epub 2012 Nov 1. Pharmacol Biochem Behav. 2013. PMID: 23123803 Free PMC article.
32 results