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Forster resonance energy transfer (FRET) correlates of altered subunit stoichiometry in cys-loop receptors, exemplified by nicotinic alpha4beta2.
Srinivasan R, Richards CI, Dilworth C, Moss FJ, Dougherty DA, Lester HA. Srinivasan R, et al. Among authors: lester ha. Int J Mol Sci. 2012;13(8):10022-10040. doi: 10.3390/ijms130810022. Epub 2012 Aug 10. Int J Mol Sci. 2012. PMID: 22949846 Free PMC article.
We predict FRET and normalized FRET (NFRET) for the two predominant stoichiometries, (alpha4)(3)(beta2)(2)vs. (alpha4)(2)(beta2)(3). Studying the ratio between FRET or NFRET for the two stoichiometries, minimizes distortions due to various photophysical uncer …
We predict FRET and normalized FRET (NFRET) for the two predominant stoichiometries, (alpha4)(3)(beta2)(2)vs. (alpha4)(2)(beta …
The 5-HT3AB receptor shows an A3B2 stoichiometry at the plasma membrane.
Miles TF, Dougherty DA, Lester HA. Miles TF, et al. Among authors: lester ha. Biophys J. 2013 Aug 20;105(4):887-98. doi: 10.1016/j.bpj.2013.07.015. Biophys J. 2013. PMID: 23972841 Free PMC article.
Twin FRET efficiencies support these data, also suggesting that the two B subunits are nonadjacent in most of the heteropentamers. ...In contrast to the findings for the plasma membrane, the relative abundances and FRET characteristics of intracellular subunits depe …
Twin FRET efficiencies support these data, also suggesting that the two B subunits are nonadjacent in most of the heteropentamers. .. …
GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRET.
Moss FJ, Imoukhuede PI, Scott K, Hu J, Jankowsky JL, Quick MW, Lester HA. Moss FJ, et al. Among authors: lester ha. J Gen Physiol. 2009 Dec;134(6):489-521. doi: 10.1085/jgp.200910314. J Gen Physiol. 2009. PMID: 19948998 Free PMC article.
Oligomerization and subsequent trafficking of mGAT1 were studied in several subcellular regions of live cells using localized fluorescence, acceptor photobleach Forster resonance energy transfer (FRET), and pixel-by-pixel analysis of normalized FRET (NFRET) images. …
Oligomerization and subsequent trafficking of mGAT1 were studied in several subcellular regions of live cells using localized fluorescence, …
Nicotine normalizes intracellular subunit stoichiometry of nicotinic receptors carrying mutations linked to autosomal dominant nocturnal frontal lobe epilepsy.
Son CD, Moss FJ, Cohen BN, Lester HA. Son CD, et al. Among authors: lester ha. Mol Pharmacol. 2009 May;75(5):1137-48. doi: 10.1124/mol.108.054494. Epub 2009 Feb 23. Mol Pharmacol. 2009. PMID: 19237585 Free PMC article.
Sixteen fluorescent subunit combinations were expressed in N2a cells. Forster resonance energy transfer (FRET) was analyzed by donor recovery after acceptor photobleaching and by pixel-by-pixel sensitized emission, with confirmation by fluorescence intensity ratios. Becaus …
Sixteen fluorescent subunit combinations were expressed in N2a cells. Forster resonance energy transfer (FRET) was analyzed by donor …
Subcellular trafficking, pentameric assembly, and subunit stoichiometry of neuronal nicotinic acetylcholine receptors containing fluorescently labeled alpha6 and beta3 subunits.
Drenan RM, Nashmi R, Imoukhuede P, Just H, McKinney S, Lester HA. Drenan RM, et al. Among authors: lester ha. Mol Pharmacol. 2008 Jan;73(1):27-41. doi: 10.1124/mol.107.039180. Epub 2007 Oct 11. Mol Pharmacol. 2008. PMID: 17932221
Using FRET, we demonstrate directly that only a single beta3 subunit is incorporated into nicotinic acetylcholine receptors (nAChRs) containing this subunit, whereas multiple subunit stoichiometries exist for alpha4- and alpha6-containing receptors. ...Furthermore, this re …
Using FRET, we demonstrate directly that only a single beta3 subunit is incorporated into nicotinic acetylcholine receptors (nAChRs) …
Assembly of alpha4beta2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons.
Nashmi R, Dickinson ME, McKinney S, Jareb M, Labarca C, Fraser SE, Lester HA. Nashmi R, et al. Among authors: lester ha. J Neurosci. 2003 Dec 17;23(37):11554-67. doi: 10.1523/JNEUROSCI.23-37-11554.2003. J Neurosci. 2003. PMID: 14684858 Free PMC article.
As expected from the hetero-multimeric nature of alpha4beta2 receptors, coexpression of the alpha4-YFP and beta2-CFP subunits resulted in robust fluorescence resonance energy transfer (FRET), with a FRET efficiency of 22%. In midbrain neurons, dendritic alpha4beta2 …
As expected from the hetero-multimeric nature of alpha4beta2 receptors, coexpression of the alpha4-YFP and beta2-CFP subunits resulted in ro …