Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors.
Shivange AV, Borden PM, Muthusamy AK, Nichols AL, Bera K, Bao H, Bishara I, Jeon J, Mulcahy MJ, Cohen B, O'Riordan SL, Kim C, Dougherty DA, Chapman ER, Marvin JS, Looger LL, Lester HA.
Shivange AV, et al. Among authors: lester ha.
J Gen Physiol. 2019 Jun 3;151(6):738-757. doi: 10.1085/jgp.201812201. Epub 2019 Feb 4.
J Gen Physiol. 2019.
PMID: 30718376
Free PMC article.
In the ER, the inside-out pathway begins when nicotine becomes a stabilizing pharmacological chaperone for some nAChR subtypes, even at concentrations as low as 10 nM. Such concentrations would persist during the 12 h of a typical smoker's day, continually activating the i …
In the ER, the inside-out pathway begins when nicotine becomes a stabilizing pharmacological chaperone for some nAChR subtypes, even …