Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors.
Shivange AV, Borden PM, Muthusamy AK, Nichols AL, Bera K, Bao H, Bishara I, Jeon J, Mulcahy MJ, Cohen B, O'Riordan SL, Kim C, Dougherty DA, Chapman ER, Marvin JS, Looger LL, Lester HA.
Shivange AV, et al. Among authors: lester ha.
J Gen Physiol. 2019 Jun 3;151(6):738-757. doi: 10.1085/jgp.201812201. Epub 2019 Feb 4.
J Gen Physiol. 2019.
PMID: 30718376
Free PMC article.
We use these data to run combined pharmacokinetic and pharmacodynamic simulations of human smoking. In the ER, the inside-out pathway begins when nicotine becomes a stabilizing pharmacological chaperone for some nAChR subtypes, even at concentrations as low as 10 nM …
We use these data to run combined pharmacokinetic and pharmacodynamic simulations of human smoking. In the ER, the inside-out …