Nuclear FGFR1 Regulates Gene Transcription and Promotes Antiestrogen Resistance in ER+ Breast Cancer.
Servetto A, Kollipara R, Formisano L, Lin CC, Lee KM, Sudhan DR, Gonzalez-Ericsson PI, Chatterjee S, Guerrero-Zotano A, Mendiratta S, Akamatsu H, James N, Bianco R, Hanker AB, Kittler R, Arteaga CL.
Servetto A, et al.
Clin Cancer Res. 2021 Aug 1;27(15):4379-4396. doi: 10.1158/1078-0432.CCR-20-3905. Epub 2021 May 19.
Clin Cancer Res. 2021.
PMID: 34011560
Free PMC article.
PURPOSE: FGFR1 overexpression has been associated with endocrine resistance in ER(+) breast cancer. We found FGFR1 localized in the nucleus of breast cancer cells in primary tumors resistant to estrogen suppression. ...RESULTS: High nuclear FGFR1 expression in ER(+) primar …
PURPOSE: FGFR1 overexpression has been associated with endocrine resistance in ER(+) breast cancer. We found FGFR1 localized in the nucle …