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Showing results for letrozole nucleus
Your search for letrozol-nucleus retrieved no results
Nuclear FGFR1 Regulates Gene Transcription and Promotes Antiestrogen Resistance in ER+ Breast Cancer.
Servetto A, Kollipara R, Formisano L, Lin CC, Lee KM, Sudhan DR, Gonzalez-Ericsson PI, Chatterjee S, Guerrero-Zotano A, Mendiratta S, Akamatsu H, James N, Bianco R, Hanker AB, Kittler R, Arteaga CL. Servetto A, et al. Clin Cancer Res. 2021 Aug 1;27(15):4379-4396. doi: 10.1158/1078-0432.CCR-20-3905. Epub 2021 May 19. Clin Cancer Res. 2021. PMID: 34011560 Free PMC article.
PURPOSE: FGFR1 overexpression has been associated with endocrine resistance in ER(+) breast cancer. We found FGFR1 localized in the nucleus of breast cancer cells in primary tumors resistant to estrogen suppression. ...RESULTS: High nuclear FGFR1 expression in ER(+) primar …
PURPOSE: FGFR1 overexpression has been associated with endocrine resistance in ER(+) breast cancer. We found FGFR1 localized in the nucle
Prenatal administration of letrozole reduces SDN and SCN volume and cell number independent of partner preference in the male rat.
Olvera-Hernández S, Tapia-Rodríguez M, Swaab DF, Fernández-Guasti A. Olvera-Hernández S, et al. Physiol Behav. 2017 Mar 15;171:61-68. doi: 10.1016/j.physbeh.2017.01.001. Epub 2017 Jan 3. Physiol Behav. 2017. PMID: 28057567
The aim of this study was to compare the volume and number of cells of the SDN and SCN (the latter nucleus was immunohistochemically stained for vasopressin) between males treated with letrozole with same-sex preference, males treated with letrozole with fema …
The aim of this study was to compare the volume and number of cells of the SDN and SCN (the latter nucleus was immunohistochemically …
Effect of Letrozole on sperm parameters, chromatin status and ROS level in idiopathic Oligo/Astheno/Teratozoospermia.
Kooshesh L, Bahmanpour S, Zeighami S, Nasr-Esfahani MH. Kooshesh L, et al. Reprod Biol Endocrinol. 2020 May 13;18(1):47. doi: 10.1186/s12958-020-00591-2. Reprod Biol Endocrinol. 2020. PMID: 32404173 Free PMC article. Clinical Trial.
Finally, the differences between the parameters evaluated before and after letrozole treatment were analyzed with the t-test and the Wilcoxon signed-rank test. ...The mean of T:E2 ratio improved 1600%. Also, letrozole treatment significantly reduced the percentage o …
Finally, the differences between the parameters evaluated before and after letrozole treatment were analyzed with the t-test and the …
Aromatase inhibitor letrozole downregulates steroid receptor coactivator-1 in specific brain regions that primarily related to memory, neuroendocrine and integration.
Bian C, Zhao Y, Guo Q, Xiong Y, Cai W, Zhang J. Bian C, et al. J Steroid Biochem Mol Biol. 2014 May;141:37-43. doi: 10.1016/j.jsbmb.2013.12.020. Epub 2014 Jan 13. J Steroid Biochem Mol Biol. 2014. PMID: 24434281
The results showed that letrozole induced dramatic decrease of SRC-1 in the medial septal, hippocampus, medial habenular nucleus, arcuate hypothalamic nucleus and superior colliculus (p<0.01). Significant decrease was detected in the dorsal lateral septal …
The results showed that letrozole induced dramatic decrease of SRC-1 in the medial septal, hippocampus, medial habenular nucleus
Aromatase, aromatase inhibitors, and breast cancer.
Brueggemeier RW. Brueggemeier RW. Am J Ther. 2001 Sep-Oct;8(5):333-44. doi: 10.1097/00045391-200109000-00007. Am J Ther. 2001. PMID: 11550075 Review.
Steroidal inhibitors that have been developed to date build on the basic androstenedione nucleus and incorporate chemical substituents at varying positions on the steroid. ...The potent and selective third-generation aromatase inhibitors anastrozole, letrozole, and …
Steroidal inhibitors that have been developed to date build on the basic androstenedione nucleus and incorporate chemical substituent …
Sex-dimorphic aromatase regulation of ventromedial hypothalamic nucleus glycogen content in euglycemic and insulin-induced hypoglycemic rats.
Ibrahim MMH, Uddin MM, Bheemanapally K, Briski KP. Ibrahim MMH, et al. Neurosci Lett. 2020 Oct 15;737:135284. doi: 10.1016/j.neulet.2020.135284. Epub 2020 Aug 25. Neurosci Lett. 2020. PMID: 32853718 Free PMC article.
Glycogen metabolism impacts metabolic transmitter signaling in the ventromedial hypothalamic nucleus (VMN), a key glucoregulatory structure. Aromatase, the enzyme that converts testosterone to estradiol, is expressed at high levels in the VMN. ...Testes-intact male and est …
Glycogen metabolism impacts metabolic transmitter signaling in the ventromedial hypothalamic nucleus (VMN), a key glucoregulatory str …
Effects of the Fertility Drugs Clomiphene Citrate and Letrozole on Kiss-1 Expression in Hypothalamic Kiss-1-Expressing Cell Models.
Oride A, Kanasaki H, Tumurbaatar T, Zolzaya T, Okada H, Hara T, Kyo S. Oride A, et al. Reprod Sci. 2020 Mar;27(3):806-814. doi: 10.1007/s43032-020-00154-1. Epub 2020 Jan 31. Reprod Sci. 2020. PMID: 32006244
We examined whether these drugs increase Kiss-1 expression in hypothalamic cell models. We utilized two hypothalamic cell models, mHypoA-50 and mHypoA-55, which originated from Kiss-1 neurons in the anteroventral periventricular (AVPV) nucleus and arcuate (AR …
We examined whether these drugs increase Kiss-1 expression in hypothalamic cell models. We utilized two hypothalamic cell mode …
Neuroestradiol regulation of ventromedial hypothalamic nucleus 5'-AMP-activated protein kinase activity and counterregulatory hormone secretion in hypoglycemic male versus female rats.
Uddin MM, Briski KP. Uddin MM, et al. AIMS Neurosci. 2020 Dec 16;8(1):133-147. doi: 10.3934/Neuroscience.2021006. eCollection 2021. AIMS Neurosci. 2020. PMID: 33490375 Free PMC article.
Hypoglycemia activates the ultra-sensitive energy gauge 5'-AMP-activated protein kinase (AMPK) in ventromedial hypothalamic nucleus (VMN) gluco-regulatory neurons. The VMN is exemplified by high levels of expression of the enzyme aromatase, which converts testosterone to e …
Hypoglycemia activates the ultra-sensitive energy gauge 5'-AMP-activated protein kinase (AMPK) in ventromedial hypothalamic nucleus ( …
Effect of Hypoglycemic Drugs on Kisspeptin Expression in the Hypothalamic Arcuate Nucleus of PCOS Rats.
Zheng P, Lu Y, Tang Y, Xu F, Wang L, Qian R, Hui C, Xu Q, He J, Deng D. Zheng P, et al. Diabetes Metab Syndr Obes. 2023 Sep 7;16:2717-2732. doi: 10.2147/DMSO.S421911. eCollection 2023. Diabetes Metab Syndr Obes. 2023. PMID: 37701721 Free PMC article.
BACKGROUND: To investigate the change in hypothalamic kisspeptin-1 (Kiss1) expression during the development of polycystic ovary syndrome (PCOS) and hypoglycemic drug intervention. METHODS: Letrozole lavage was used to construct a polycystic ovary rat model. ...
BACKGROUND: To investigate the change in hypothalamic kisspeptin-1 (Kiss1) expression during the development of polycystic ovary syndrome (P …
Aromatase inhibitors in the treatment of breast cancer.
Brueggemeier RW, Hackett JC, Diaz-Cruz ES. Brueggemeier RW, et al. Endocr Rev. 2005 May;26(3):331-45. doi: 10.1210/er.2004-0015. Epub 2005 Apr 6. Endocr Rev. 2005. PMID: 15814851 Review.
Steroidal inhibitors that have been developed to date build upon the basic androstenedione nucleus and incorporate chemical substituents at varying positions on the steroid. ...The potent and selective third-generation aromatase inhibitors, anastrozole, letrozole, a …
Steroidal inhibitors that have been developed to date build upon the basic androstenedione nucleus and incorporate chemical substitue …
42 results