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834 results

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Page 1
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Franik S, Le QK, Kremer JA, Kiesel L, Farquhar C. Franik S, et al. Cochrane Database Syst Rev. 2022 Sep 27;9(9):CD010287. doi: 10.1002/14651858.CD010287.pub4. Cochrane Database Syst Rev. 2022. PMID: 36165742 Free PMC article.
Aromatase inhibitors (AIs) are a class of drugs that were introduced for ovulation induction in 2001. Since about 2001 clinical trials have reached differing conclusions as to whether the AI, letrozole, is at least as effective as the first-line treatment clomiphene …
Aromatase inhibitors (AIs) are a class of drugs that were introduced for ovulation induction in 2001. Since about 2001 clinical trial …
Letrozole for Female Infertility.
Yang AM, Cui N, Sun YF, Hao GM. Yang AM, et al. Front Endocrinol (Lausanne). 2021 Jun 16;12:676133. doi: 10.3389/fendo.2021.676133. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34220713 Free PMC article. Review.
It has been more than 20 years since the initial clinical trial of letrozole for ovulation induction. In light of the accumulating clinical and basic evidence, the efficacy and safety of letrozole have been identified. This mini review focuses on our current …
It has been more than 20 years since the initial clinical trial of letrozole for ovulation induction. In light of the accumula …
Letrozole and clomiphene versus letrozole alone for ovulation induction in women with PCOS: a systematic review and meta-analysis.
Eskandar K, Oliveira JA, Ribeiro SA, Chavez MP, Zotti AIA, Dias YJM, Novellino AMM. Eskandar K, et al. Rev Bras Ginecol Obstet. 2025 Apr 30;47:e-rbgo21. doi: 10.61622/rbgo/2025rbgo21. eCollection 2025. Rev Bras Ginecol Obstet. 2025. PMID: 40406474 Free PMC article.
OBJECTIVE: We aimed to compare the efficacy and safety of letrozole and clomiphene versus letrozole alone for ovulation induction in patients with Polycystic Ovary Syndrome (PCOS). ...STUDY SELECTION: We included studies of women with PCOS treated with a comb …
OBJECTIVE: We aimed to compare the efficacy and safety of letrozole and clomiphene versus letrozole alone for ovulation …
Comparing efficacy and safety of stair step protocols for clomiphene citrate and letrozole in ovulation induction for women with polycystic ovary syndrome (PCOS): a randomized controlled clinical trial.
Al-Thuwaynee S, Swadi AAJ. Al-Thuwaynee S, et al. J Med Life. 2023 May;16(5):725-730. doi: 10.25122/jml-2023-0069. J Med Life. 2023. PMID: 37520487 Free PMC article. Clinical Trial.
The pregnancy rate was slightly higher in the letrozole group (22.0% vs 18.0%), but also not statistically significant (p=0.617). However, the mean time from menstruation to ovulation was significantly shorter in the letrozole group (17.20 1.32 days) compared …
The pregnancy rate was slightly higher in the letrozole group (22.0% vs 18.0%), but also not statistically significant (p=0.617). How …
Letrozole for Ovulation Induction in Women With Polycystic Ovary Syndrome.
Li XL. Li XL. Obstet Gynecol Surv. 2026 Apr 1;81(4):186-191. doi: 10.1097/OGX.0000000000001494. Epub 2026 Apr 10. Obstet Gynecol Surv. 2026. PMID: 41950500 Free article. Review.
CONCLUSIONS: Letrozole is effective for inducing ovulation and achieving pregnancy in patients with PCOS, and report variations in letrozole treatment protocols. RELEVANCE: Better understanding of letrozole for ovulation induction is important f …
CONCLUSIONS: Letrozole is effective for inducing ovulation and achieving pregnancy in patients with PCOS, and report variation …
Higher ovulation rate with letrozole as compared with clomiphene citrate in infertile women with polycystic ovary syndrome: a systematic review and meta-analysis.
Tsiami AP, Goulis DG, Sotiriadis AI, Kolibianakis EM. Tsiami AP, et al. Hormones (Athens). 2021 Sep;20(3):449-461. doi: 10.1007/s42000-021-00289-z. Epub 2021 May 25. Hormones (Athens). 2021. PMID: 34033068
However, the use of letrozole as an ovulation induction agent is not FDA or EMA approved, and its use is "off-label." ...CONCLUSION: A higher probability of ovulation is expected in infertile patients with PCOS treated with letrozole as compared to CC. …
However, the use of letrozole as an ovulation induction agent is not FDA or EMA approved, and its use is "off-label." ...CONCL …
Letrozole: Pharmacology, toxicity and potential therapeutic effects.
Mukherjee AG, Wanjari UR, Nagarajan D, K K V, V A, P JP, T TP, Chakraborty R, Renu K, Dey A, Vellingiri B, Gopalakrishnan AV. Mukherjee AG, et al. Life Sci. 2022 Dec 1;310:121074. doi: 10.1016/j.lfs.2022.121074. Epub 2022 Oct 13. Life Sci. 2022. PMID: 36243120 Review.
The highly active estrogen metabolism and receptor protein expression are to blame for the elevated breast cancer (BC) rate in post-menopausal women. Letrozole is a powerful endocrine medication that targets and inhibits the aromatase, often known as an aromatase inhibitor …
The highly active estrogen metabolism and receptor protein expression are to blame for the elevated breast cancer (BC) rate in post-menopaus …
Combined Letrozole and Clomiphene Citrate Versus Letrozole Alone in Ovulation Induction for Polycystic Ovarian Syndrome Patients: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Alhebshi ZA, Alqarni DH, Najjar AA, Alshalahi SS, Alhatlani RA, Jamal A, Wasaya HMI, Almehmadi M, Alrafi MA, AlHabardi N. Alhebshi ZA, et al. Reprod Sci. 2025 Nov;32(11):3525-3538. doi: 10.1007/s43032-025-01979-4. Epub 2025 Oct 21. Reprod Sci. 2025. PMID: 41120691
Six RCTs with 619 PCOS patients were included. The combination of Letrozole and CC resulted in a higher, though non-significant, ovulation rate (53.74%) vs. Letrozole alone (40.08%) (OR 1.22, 95% CI [0.88, 1.69], P = 0.23). Lower-dose combination therapy (50 …
Six RCTs with 619 PCOS patients were included. The combination of Letrozole and CC resulted in a higher, though non-significant, o …
Comparison of Letrozole Versus Combination Letrozole and Clomiphene Citrate (CC) for Ovulation Induction in Sub Fertile Women with Polycystic Ovarian Syndrome (PCOS)-An Open Label Randomized Control Trial.
Sarkar S, Gupta N, Joseph T, Yadav B, Kunjummen AT, Kamath MS. Sarkar S, et al. Reprod Sci. 2024 Dec;31(12):3834-3842. doi: 10.1007/s43032-024-01743-0. Epub 2024 Nov 5. Reprod Sci. 2024. PMID: 39500849 Clinical Trial.
To evaluate the effectiveness of Letrozole and Clomiphene (CC) combination versus Letrozole alone for ovulation induction in infertile women with PCOS. ...The woman per cycle ovulation rate following Letrozole and CC combination versus Letroz …
To evaluate the effectiveness of Letrozole and Clomiphene (CC) combination versus Letrozole alone for ovulation inducti …
Letrozole versus clomiphene for infertility in the polycystic ovary syndrome.
Legro RS, Brzyski RG, Diamond MP, Coutifaris C, Schlaff WD, Casson P, Christman GM, Huang H, Yan Q, Alvero R, Haisenleder DJ, Barnhart KT, Bates GW, Usadi R, Lucidi S, Baker V, Trussell JC, Krawetz SA, Snyder P, Ohl D, Santoro N, Eisenberg E, Zhang H; NICHD Reproductive Medicine Network. Legro RS, et al. N Engl J Med. 2014 Jul 10;371(2):119-29. doi: 10.1056/NEJMoa1313517. N Engl J Med. 2014. PMID: 25006718 Free PMC article. Clinical Trial.
The cumulative ovulation rate was higher with letrozole than with clomiphene (834 of 1352 treatment cycles [61.7%] vs. 688 of 1425 treatment cycles [48.3%], P<0.001). ...CONCLUSIONS: As compared with clomiphene, letrozole was associated with higher live-bi …
The cumulative ovulation rate was higher with letrozole than with clomiphene (834 of 1352 treatment cycles [61.7%] vs. 688 of …
834 results