Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1880 1
1905 1
1907 2
1912 1
1919 1
1921 1
1923 1
1928 1
1932 1
1934 1
1935 1
1936 1
1940 2
1941 1
1943 1
1944 1
1945 5
1946 9
1947 8
1948 15
1949 11
1950 9
1951 21
1952 15
1953 10
1954 11
1955 27
1956 28
1957 33
1958 29
1959 50
1960 68
1961 99
1962 120
1963 269
1964 479
1965 431
1966 473
1967 651
1968 757
1969 934
1970 936
1971 1158
1972 1228
1973 1241
1974 1285
1975 1129
1976 974
1977 910
1978 806
1979 888
1980 925
1981 981
1982 1014
1983 1073
1984 1190
1985 1153
1986 1194
1987 1063
1988 1104
1989 1147
1990 1318
1991 1347
1992 1384
1993 1420
1994 1434
1995 1463
1996 1448
1997 1524
1998 1581
1999 1577
2000 1719
2001 1753
2002 1727
2003 1749
2004 1918
2005 1911
2006 2063
2007 2115
2008 2073
2009 2148
2010 2268
2011 2464
2012 2526
2013 2691
2014 2661
2015 2618
2016 2715
2017 2695
2018 2861
2019 2967
2020 3228
2021 3320
2022 3254
2023 3225
2024 3388
2025 3612
2026 2109
2027 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

100,938 results

Results by year

Filters applied: . Clear all
Page 1
Double-Edge Effects of Leucine on Cancer Cells.
Akbay B, Omarova Z, Trofimov A, Sailike B, Karapina O, Molnár F, Tokay T. Akbay B, et al. Biomolecules. 2024 Nov 4;14(11):1401. doi: 10.3390/biom14111401. Biomolecules. 2024. PMID: 39595578 Free PMC article. Review.
Leucine is an essential amino acid that cannot be produced endogenously in the human body and therefore needs to be obtained from dietary sources. ...Interestingly, cancer research suggests that leucine may have either anti-cancer or pro-tumorigenic effects. In the …
Leucine is an essential amino acid that cannot be produced endogenously in the human body and therefore needs to be obtained from die …
Leucine Supplementation in Cancer Cachexia: Mechanisms and a Review of the Pre-Clinical Literature.
Beaudry AG, Law ML. Beaudry AG, et al. Nutrients. 2022 Jul 9;14(14):2824. doi: 10.3390/nu14142824. Nutrients. 2022. PMID: 35889781 Free PMC article. Review.
Multiple pre-clinical studies have explored the impact of leucine supplementation in cachectic tumor-bearing hosts. Here, we provide an overview of leucine's proposed modes of action to preserve lean mass in cachexia and review the current pre-clinical literature re …
Multiple pre-clinical studies have explored the impact of leucine supplementation in cachectic tumor-bearing hosts. Here, we provide …
Leucine supplementation and intensive training.
Mero A. Mero A. Sports Med. 1999 Jun;27(6):347-58. doi: 10.2165/00007256-199927060-00001. Sports Med. 1999. PMID: 10418071 Review.
Leucine, isoleucine and valine, the branched-chain amino acids (BCAA), make up about one-third of muscle protein. ...During 5 weeks of strength and speed training, leucine supplementation of 50 mg/kg bodyweight/day, supplementary to a daily protein intake of 1.26 g/ …
Leucine, isoleucine and valine, the branched-chain amino acids (BCAA), make up about one-third of muscle protein. ...During 5 weeks o …
Leucine-induced anabolic-catabolism: two sides of the same coin.
Gannon NP, Vaughan RA. Gannon NP, et al. Amino Acids. 2016 Feb;48(2):321-36. doi: 10.1007/s00726-015-2109-8. Amino Acids. 2016. PMID: 26476924 Review.
The unique ability of leucine to stimulate both favorable anabolic and catabolic processes in highly metabolically active tissues suggests leucine consumption/supplementation may provide benefits beyond hypertrophic gains. ...The role of cellular energetics is of un …
The unique ability of leucine to stimulate both favorable anabolic and catabolic processes in highly metabolically active tissues sug …
Dietary leucine intake and sarcopenia: from isolated supplementation to combined strategies.
Walrand S, Le Bacquer O. Walrand S, et al. Curr Opin Clin Nutr Metab Care. 2026 Jan 1;29(1):75-80. doi: 10.1097/MCO.0000000000001180. Epub 2025 Nov 7. Curr Opin Clin Nutr Metab Care. 2026. PMID: 41201844 Review.
RECENT FINDINGS: Recent studies confirm that leucine supplementation alone fails to significantly improve muscle mass or strength in older adults. ...SUMMARY: These findings underscore the need for multimodal approaches, leucine, optimized nutrition, exercise, and m …
RECENT FINDINGS: Recent studies confirm that leucine supplementation alone fails to significantly improve muscle mass or strength in …
Leucine and protein synthesis: mTOR and beyond.
Stipanuk MH. Stipanuk MH. Nutr Rev. 2007 Mar;65(3):122-9. doi: 10.1111/j.1753-4887.2007.tb00289.x. Nutr Rev. 2007. PMID: 17425063 Review.
The effects of amino acid intake on protein synthesis in the intact rat appear to be mediated almost entirely by a single amino acid: leucine. The effect of leucine on protein synthesis appears to be closely associated with eIF4G phosphorylation and its association …
The effects of amino acid intake on protein synthesis in the intact rat appear to be mediated almost entirely by a single amino acid: leu …
Effect of supplementation with leucine alone, with other nutrients or with physical exercise in older people with sarcopenia: a systematic review.
Conde Maldonado E, Marqués-Jiménez D, Casas-Agustench P, Bach-Faig A. Conde Maldonado E, et al. Endocrinol Diabetes Nutr (Engl Ed). 2022 Oct;69(8):601-613. doi: 10.1016/j.endien.2022.11.012. Epub 2022 Nov 14. Endocrinol Diabetes Nutr (Engl Ed). 2022. PMID: 36396594
RESULTS: The systematic review identified three intervention studies examining the effect of leucine without physical exercise, one on leucine with physical exercise, seven on leucine paired with another nutrient and without physical exercise, and twelve on …
RESULTS: The systematic review identified three intervention studies examining the effect of leucine without physical exercise, one o …
Leucine acutely potentiates glucose-stimulated insulin secretion in fetal sheep.
Boehmer BH, Baker PR, Brown LD, Wesolowski SR, Rozance PJ. Boehmer BH, et al. J Endocrinol. 2020 Oct;247(1):115-126. doi: 10.1530/JOE-20-0243. J Endocrinol. 2020. PMID: 32756000 Free PMC article.
These mechanisms involve leucine metabolism, including leucine oxidation. However, it is not clear if leucine-stimulated metabolic pathways are active in fetal islets. ...Isolated fetal islets oxidized leucine. Leucine supplementation of isolate …
These mechanisms involve leucine metabolism, including leucine oxidation. However, it is not clear if leucine-stimulate …
Safety and Tolerability of Leucine Supplementation in Elderly Men.
Elango R, Rasmussen B, Madden K. Elango R, et al. J Nutr. 2016 Dec;146(12):2630S-2634S. doi: 10.3945/jn.116.234930. Epub 2016 Nov 9. J Nutr. 2016. PMID: 27934655 Free article. Review.
Although leucine supplementation may be beneficial, the efficacious dose of leucine is unknown. Before conducting studies with increased doses of leucine, the Tolerable Upper Intake Level (UL) for leucine needs to be determined. The objective of this r …
Although leucine supplementation may be beneficial, the efficacious dose of leucine is unknown. Before conducting studies with …
Leucine metabolism in man: lessons from modeling.
Matthews DE, Cobelli C. Matthews DE, et al. JPEN J Parenter Enteral Nutr. 1991 May-Jun;15(3):86S-89S. doi: 10.1177/014860719101500386S. JPEN J Parenter Enteral Nutr. 1991. PMID: 1865565 Review.
However, administering a leucine tracer and following it in blood will not adequately reflect the complex, multi-pool nature of the leucine system. Using the tracer enrichment of the ketoacid metabolite of leucine, alpha-ketoisocaproate (KIC), to reflect intr …
However, administering a leucine tracer and following it in blood will not adequately reflect the complex, multi-pool nature of the …
100,938 results
You have reached the last available page of results. Please see the User Guide for more information.