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Page 1
Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis.
Ye J, Zhong S, Wan H, Guo X, Yao X, Liu Q, Chen L, Wang JZ, Xiao S. Ye J, et al. Mol Neurodegener. 2025 Jan 13;20(1):5. doi: 10.1186/s13024-025-00796-2. Mol Neurodegener. 2025. PMID: 39806423 Free PMC article.
BACKGROUND: Astrocytes, the most abundant glial cell type in the brain, will convert into the reactive state in response to proteotoxic stress such as tau accumulation, a characteristic feature of Alzheimer's disease (AD) and other tauopathies. ...PS19 mice were treated wi …
BACKGROUND: Astrocytes, the most abundant glial cell type in the brain, will convert into the reactive state in response to proteotox …
Cognitive outcomes in anti-LGI-1 encephalitis.
Galioto R, Aboseif A, Krishnan K, Lace J, Kunchok A. Galioto R, et al. J Int Neuropsychol Soc. 2023 Jul;29(6):541-550. doi: 10.1017/S1355617722000509. Epub 2022 Sep 5. J Int Neuropsychol Soc. 2023. PMID: 36062531
OBJECTIVE: Cognitive impairment is one of the most common symptoms of anti-leucine rich glioma inactivated 1 (anti-LGI-1) encephalitis, but little is known about the cognitive profile of these patients. ...
OBJECTIVE: Cognitive impairment is one of the most common symptoms of anti-leucine rich glioma inactivated 1 (anti-LGI-1) encephaliti …
Oridonin Ameliorates Traumatic Brain Injury-Induced Neurological Damage by Improving Mitochondrial Function and Antioxidant Capacity and Suppressing Neuroinflammation through the Nrf2 Pathway.
Zhao XJ, Zhu HY, Wang XL, Lu XW, Pan CL, Xu L, Liu X, Xu N, Zhang ZY. Zhao XJ, et al. J Neurotrauma. 2022 Apr;39(7-8):530-543. doi: 10.1089/neu.2021.0466. Epub 2022 Feb 28. J Neurotrauma. 2022. PMID: 35102762
Traumatic brain injury (TBI) is a global public health concern, and few effective treatments for its delayed damages are available. ...The results therefore suggest Ori as a potent candidate for managing neurological damage after TBI....
Traumatic brain injury (TBI) is a global public health concern, and few effective treatments for its delayed damages are available. . …
Parkinson's disease associated with LRRK2-R1441C mutation: Characterization and comparison with other LRRK2 mutations.
Hadad R, Alcalay RN, Senderova I, Nassar M, Milicic A, Peretz JA, Allen IE, Ben-Hayun R, Chasnyk N, Morani I, Elkoshi N, Valcour V, Schlesinger I. Hadad R, et al. J Parkinsons Dis. 2025 Aug;15(5):1029-1034. doi: 10.1177/1877718X251354986. Epub 2025 Jul 4. J Parkinsons Dis. 2025. PMID: 40611668 Free PMC article.
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene associate with familial and sporadic Parkinson's disease (PD). ...These results need confirmation in larger, more diverse samples. Parkinson's disease (PD) is a brain disorder that affects movement and think …
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene associate with familial and sporadic Parkinson's disease (PD). ...These re …
Emerging psychiatric syndromes associated with antivoltage-gated potassium channel complex antibodies.
Prüss H, Lennox BR. Prüss H, et al. J Neurol Neurosurg Psychiatry. 2016 Nov;87(11):1242-1247. doi: 10.1136/jnnp-2015-313000. Epub 2016 Jul 19. J Neurol Neurosurg Psychiatry. 2016. PMID: 27435086 Review.
These initial case descriptions were of a progressive neuropsychiatric syndrome with abnormalities of mood, sleep and cognition recognised alongside the neurological symptoms of seizures and autonomic instability. ...The understanding of the pathogenic nature of VGK …
These initial case descriptions were of a progressive neuropsychiatric syndrome with abnormalities of mood, sleep and cognition recog …
Deletion of JDP2 improves neurological outcomes of traumatic brain injury (TBI) in mice: Inactivation of Caspase-3.
Wang XH, Liu Q, Shao ZT. Wang XH, et al. Biochem Biophys Res Commun. 2018 Oct 12;504(4):805-811. doi: 10.1016/j.bbrc.2018.08.055. Epub 2018 Sep 11. Biochem Biophys Res Commun. 2018. PMID: 30217453
Traumatic brain injury (TBI) is a major cause of death and disability, also resulting in long-term serious neurological impairment in survivors. ...Collectively, JDP2 knockout effectively attenuate TBI in vivo and in vitro through blocking Caspase-3 activation, prov …
Traumatic brain injury (TBI) is a major cause of death and disability, also resulting in long-term serious neurological impair …
Biomarkers of Leucine-Rich Repeat Kinase 2 (LRRK2) and Lysosomal Dysfunction in Progressive Supranuclear Palsy.
Nielsen LK, Frost JLI, Vaughan DP, Real R, Fumi R, Jensen MT, Hodgson M, Stafford EJ, Wu L, Ansorge O, Quaegebeur A, Allinson KSJ, Warner TT, Jaunmuktane Z, Misbahuddin A, Leigh PN, Ghosh BCP, Bhatia KP, Church A, Kobylecki C, Hu MTM, Rowe JB, Shomo AA, Graham DL, Mabrouk OS, Morris HR, Sammler EM, Jabbari E. Nielsen LK, et al. Mov Disord. 2026 Jul;41(7):1740-1749. doi: 10.1002/mds.70295. Epub 2026 Apr 15. Mov Disord. 2026. PMID: 41987507
BACKGROUND: Common and rare genetic variants in leucine-rich repeat kinase 2 (LRRK2) have been linked with sporadic and familial Parkinson's disease (PD). ...
BACKGROUND: Common and rare genetic variants in leucine-rich repeat kinase 2 (LRRK2) have been linked with sporadic and familial Park …
Progression in the LRRK2-Asssociated Parkinson Disease Population.
Saunders-Pullman R, Mirelman A, Alcalay RN, Wang C, Ortega RA, Raymond D, Mejia-Santana H, Orbe-Reilly M, Johannes BA, Thaler A, Ozelius L, Orr-Urtreger A, Marder KS, Giladi N, Bressman SB; LRRK2 Ashkenazi Jewish Consortium. Saunders-Pullman R, et al. JAMA Neurol. 2018 Mar 1;75(3):312-319. doi: 10.1001/jamaneurol.2017.4019. JAMA Neurol. 2018. PMID: 29309488 Free PMC article.
IMPORTANCE: Few prospective longitudinal studies have evaluated the progression of Parkinson disease (PD) in patients with the leucine-rich repeat kinase 2 (LRRK2 [OMIM 609007]) mutation. Knowledge about such progression will aid clinical trials. ...Mixed-effects models we …
IMPORTANCE: Few prospective longitudinal studies have evaluated the progression of Parkinson disease (PD) in patients with the leucine …
Loss of the Immunomodulatory Transcription Factor BATF2 in Humans Is Associated with a Neurological Phenotype.
Zsurka G, Appel MLT, Nastaly M, Hallmann K, Hansen N, Nass D, Baumgartner T, Surges R, Hartmann G, Bartok E, Kunz WS. Zsurka G, et al. Cells. 2023 Jan 5;12(2):227. doi: 10.3390/cells12020227. Cells. 2023. PMID: 36672163 Free PMC article.
Epilepsy and mental retardation are known to be associated with pathogenic mutations in a broad range of genes that are expressed in the brain and have a role in neurodevelopment. Here, we report on a family with three affected individuals whose clinical symptoms closely r …
Epilepsy and mental retardation are known to be associated with pathogenic mutations in a broad range of genes that are expressed in the …
26 results