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149 results

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Page 1
International society of sports nutrition position stand: β-hydroxy-β-methylbutyrate (HMB).
Rathmacher JA, Pitchford LM, Stout JR, Townsend JR, Jäger R, Kreider RB, Campbell BI, Kerksick CM, Harty PS, Candow DG, Roberts BM, Arent SM, Kalman DS, Antonio J. Rathmacher JA, et al. J Int Soc Sports Nutr. 2025 Dec;22(1):2434734. doi: 10.1080/15502783.2024.2434734. Epub 2024 Dec 19. J Int Soc Sports Nutr. 2025. PMID: 39699070 Free PMC article. Review.
HMB-FA appears to lead to increased appearance of HMB in the bloodstream when compared to HMB-Ca, though recent results are mixed. 2. The available safety/toxicity data suggest that chronic HMB-Ca and HMB-FA consumption are safe for oral HMB supplementation in human …
HMB-FA appears to lead to increased appearance of HMB in the bloodstream when compared to HMB-Ca, though recent results are mixed. 2. The av …
Efficacy and Safety of Leucine Supplementation in the Elderly.
Borack MS, Volpi E. Borack MS, et al. J Nutr. 2016 Dec;146(12):2625S-2629S. doi: 10.3945/jn.116.230771. Epub 2016 Nov 9. J Nutr. 2016. PMID: 27934654 Free PMC article. Review.
Similarly, no adverse events have been reported for the leucine metabolite beta-hydroxy-beta-methylbutyrate (HMB), although no studies have tested HMB toxicity in humans. Therefore, future research is needed to evaluate leucine and HMB toxicity in the …
Similarly, no adverse events have been reported for the leucine metabolite beta-hydroxy-beta-methylbutyrate (HMB), although no studie …
Petosemtamab, a Bispecific Antibody Targeting Epidermal Growth Factor Receptor (EGFR) and Leucine-Rich G Repeat-Containing Protein-Coupled Receptor (LGR5) Designed for Broad Clinical Applications.
Lundberg AS, Geuijen CAW, Hill S, Lammerts van Bueren JJ, Fumagalli A, de Kruif J, Silverman PB, Tabernero J. Lundberg AS, et al. Cancers (Basel). 2025 May 14;17(10):1665. doi: 10.3390/cancers17101665. Cancers (Basel). 2025. PMID: 40427162 Free PMC article. Review.
These stem-cell-like cells express the leucine-rich G repeat-containing protein-coupled receptor 5 (LGR5) and have characteristics similar to tissue-resident stem cells in normal adult tissues such as the colon. ...Petosemtamab has demonstrated substantial clinical activit …
These stem-cell-like cells express the leucine-rich G repeat-containing protein-coupled receptor 5 (LGR5) and have characteristics si …
A Toxicological Assessment of Creatyl-l-Leucine.
Reddeman RA, Glávits R, Endres JR, Murbach TS, Hirka G, Vértesi A, Béres E, Szakonyiné IP. Reddeman RA, et al. Int J Toxicol. 2018 Mar/Apr;37(2):171-187. doi: 10.1177/1091581817751142. Epub 2018 Jan 22. Int J Toxicol. 2018. PMID: 29357766
A battery of toxicological studies was conducted to investigate the genotoxicity and repeated-dose oral toxicity of creatyl-l-leucine, a synthetic compound, in rats in accordance with internationally accepted guidelines. ...There was no genotoxic activity observed i …
A battery of toxicological studies was conducted to investigate the genotoxicity and repeated-dose oral toxicity of creatyl-l-leuc …
The efficacy and safety of leucine-enriched essential amino acids in knee osteoarthritis patients: A randomized controlled trial.
Park SJ, Nam CH, Ahn HS, Kim T. Park SJ, et al. Medicine (Baltimore). 2024 May 10;103(19):e38168. doi: 10.1097/MD.0000000000038168. Medicine (Baltimore). 2024. PMID: 38728455 Free PMC article. Clinical Trial.

A significantly higher efficacy was observed in the experimental group than in the control group, as indicated by muscle density in the DEXA scan (P = .001) and SF-36 (P < .001). The safety evaluation revealed no related generalized or local protein allergy. Hematologic

…
A significantly higher efficacy was observed in the experimental group than in the control group, as indicated by muscle density in the DEXA …
Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson's disease.
Liang X, Zeng Y, Zhang P, Zhu B, Feng J, Deng T, Fu Z, Liu C, Chen C, Zhang Y. Liang X, et al. J Transl Med. 2025 Jun 5;23(1):631. doi: 10.1186/s12967-025-06634-9. J Transl Med. 2025. PMID: 40474178 Free PMC article.
Evans blue staining and TEM showed PS-NPs damaged the BBB. The 30-day oral toxicity revealed that PS-NPs exacerbated behavioral abnormalities and caused dopaminergic neuron loss. ...The molecular mechanisms could inform environmental safety regulations concerning na …
Evans blue staining and TEM showed PS-NPs damaged the BBB. The 30-day oral toxicity revealed that PS-NPs exacerbated behavioral abnor …
Modular chimeric cytokine receptors with leucine zippers enhance the antitumour activity of CAR T cells via JAK/STAT signalling.
Bell M, Lange S, Sejdiu BI, Ibanez J, Shi H, Sun X, Meng X, Nguyen P, Sutton M, Wagner J, Kc A, Langfitt D, Patil SL, Tan H, Pandey RV, Li Y, Yuan ZF, Anido AA, Ho M, Sheppard H, Vogel P, Yu J, Peng J, Chi H, Babu MM, Krenciute G, Gottschalk S. Bell M, et al. Nat Biomed Eng. 2024 Apr;8(4):380-396. doi: 10.1038/s41551-023-01143-w. Epub 2023 Nov 30. Nat Biomed Eng. 2024. PMID: 38036617 Free PMC article.
However, these strategies are constrained by toxicity arising from the activation of bystander cells, by the suboptimal biodistribution of the cytokines and by downregulation of the cognate receptor. Here we show that replacement of the extracellular domains of heterodimer …
However, these strategies are constrained by toxicity arising from the activation of bystander cells, by the suboptimal biodistributi …
Sepsis toxicity network reconstruction-Dynamic signaling and multi-organ injury: A review.
Liu S, Liang Q. Liu S, et al. Biomol Biomed. 2025 Sep 2;26(2):262-273. doi: 10.17305/bb.2025.12931. Biomol Biomed. 2025. PMID: 40891647 Free PMC article. Review.
Sepsis is a complex systemic disease in which systemic toxicity-arising from inflammation-immune dysregulation, oxidative stress, programmed cell death (apoptosis, pyroptosis, ferroptosis), and metabolic reprogramming-drives multi-organ injury. ...Therapeutic progress has …
Sepsis is a complex systemic disease in which systemic toxicity-arising from inflammation-immune dysregulation, oxidative stress, pro …
Genotoxicity assessment of calcium β-hydroxy-β-methylbutyrate.
Pitchford LM, Fuller JC Jr, Rathmacher JA. Pitchford LM, et al. Regul Toxicol Pharmacol. 2018 Dec;100:68-71. doi: 10.1016/j.yrtph.2018.10.016. Epub 2018 Oct 22. Regul Toxicol Pharmacol. 2018. PMID: 30359700 Free article.
beta-Hydroxy-beta-methylbutyrate (HMB) is a leucine metabolite available in calcium salt (CaHMB) and free acid forms as a sports nutrition ergogenic aid. HMB has also been used to support muscle health in the elderly and other populations needing to maintain muscle mass. S …
beta-Hydroxy-beta-methylbutyrate (HMB) is a leucine metabolite available in calcium salt (CaHMB) and free acid forms as a sports nutr …
Application of PD-1 Blockade in Cancer Immunotherapy.
Wu X, Gu Z, Chen Y, Chen B, Chen W, Weng L, Liu X. Wu X, et al. Comput Struct Biotechnol J. 2019 May 23;17:661-674. doi: 10.1016/j.csbj.2019.03.006. eCollection 2019. Comput Struct Biotechnol J. 2019. PMID: 31205619 Free PMC article. Review.
Here, we review the progresses on the studies of the mechanistic role of PD-1 pathway in the tumor immune evasion, recent clinical development and commercialization of PD-1 pathway inhibitors, the toxicities associated with PD-1 blockade observed in clinical trials as well …
Here, we review the progresses on the studies of the mechanistic role of PD-1 pathway in the tumor immune evasion, recent clinical developme …
149 results