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The combined oral contraceptive pill containing drospirenone and ethinyl estradiol plus levomefolate calcium.
Rapkin RB, Creinin MD. Rapkin RB, et al. Expert Opin Pharmacother. 2011 Oct;12(15):2403-10. doi: 10.1517/14656566.2011.610791. Epub 2011 Aug 31. Expert Opin Pharmacother. 2011. PMID: 21877996 Review.
A new oral contraceptive containing drospirenone and ethinyl estradiol plus levomefolate calcium was formulated to decrease the risk of neural tube defects in pregnancies conceived while taking or shortly after discontinuing this pill. ...Additionally, we review stu …
A new oral contraceptive containing drospirenone and ethinyl estradiol plus levomefolate calcium was formulated to decrease th …
Bioequivalence evaluation of a folate-supplemented oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium versus ethinylestradiol/drospirenone and levomefolate calcium alone.
Wiesinger H, Eydeler U, Richard F, Trummer D, Blode H, Rohde B, Diefenbach K. Wiesinger H, et al. Clin Drug Investig. 2012 Oct 1;32(10):673-84. doi: 10.1007/BF03261921. Clin Drug Investig. 2012. PMID: 22909145 Clinical Trial.
OBJECTIVE: This study aimed to demonstrate bioequivalence of ethinylestradiol (EE), drospirenone and L-5-methyl-tetrahydrofolate (L-5-methyl-THF; active moiety of levomefolate calcium) when taken as a new folate-supplemented OC containing EE/drospirenone/levomefo …
OBJECTIVE: This study aimed to demonstrate bioequivalence of ethinylestradiol (EE), drospirenone and L-5-methyl-tetrahydrofolate (L-5-methyl …
Bioequivalence study of an oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium relative to ethinylestradiol/drospirenone and to levomefolate calcium alone.
Blode H, Klipping C, Richard F, Trummer D, Rohde B, Diefenbach K. Blode H, et al. Contraception. 2012 Feb;85(2):177-84. doi: 10.1016/j.contraception.2011.05.015. Epub 2011 Jul 19. Contraception. 2012. PMID: 22067789 Clinical Trial.
BACKGROUND: A new tablet formulation containing 0.02 mg ethinylestradiol/3 mg drospirenone/0.451 mg levomefolate calcium (calcium salt containing 0.416 mg L-5-methyltetrahydrofolate) was assessed for bioequivalence compared to the approved oral contraceptive (OC) ta …
BACKGROUND: A new tablet formulation containing 0.02 mg ethinylestradiol/3 mg drospirenone/0.451 mg levomefolate calcium (calc …
EE-drospirenone-levomefolate calcium versus EE-drospirenone + folic acid: folate status during 24 weeks of treatment and over 20 weeks following treatment cessation.
Diefenbach K, Trummer D, Ebert F, Lissy M, Koch M, Rohde B, Blode H. Diefenbach K, et al. Int J Womens Health. 2013 Apr 11;5:149-63. doi: 10.2147/IJWH.S37254. Print 2013. Int J Womens Health. 2013. PMID: 23610531 Free PMC article.
During the invasion phase, plasma and RBC folate concentrations increased and approached steady-state after about 8 weeks (plasma) or 24 weeks (RBC). After cessation of treatment with levomefolate calcium, folate concentrations decreased slowly. The median time to R …
During the invasion phase, plasma and RBC folate concentrations increased and approached steady-state after about 8 weeks (plasma) or 24 wee …
Beyaz®: an oral contraceptive fortified with folate.
Fruzzetti F. Fruzzetti F. Womens Health (Lond). 2012 Jan;8(1):13-9. doi: 10.2217/whe.11.68. Womens Health (Lond). 2012. PMID: 22171769 Free article. Review.
Beyaz() (Bayer HealthCare Pharmaceuticals, Berlin, Germany) consists of 28 film-coated tablets: 24 tablets each containing 3 mg drospirenone plus 20 g ethinylestradiol (EE) and 451 g levomefolate calcium followed by four tablets, each containing 451 g levomefolat …
Beyaz() (Bayer HealthCare Pharmaceuticals, Berlin, Germany) consists of 28 film-coated tablets: 24 tablets each containing 3 mg drospirenone …
Comprehensive evaluation of Safyral(®) 2012.
Nelson AL. Nelson AL. Womens Health (Lond). 2012 Nov;8(6):619-33. doi: 10.2217/whe.12.50. Womens Health (Lond). 2012. PMID: 23181528 Free article. Review.
Since birth control pills are the most popular method of reversible contraception in the USA, it would seem quite logical to find a way to supplement them. To this end, a very efficient folate, levomefolate calcium salt (metafolin), has been added to drospirenone-co …
Since birth control pills are the most popular method of reversible contraception in the USA, it would seem quite logical to find a way to s …
Improved conjunctival microcirculation in diabetic retinopathy patients with MTHFR polymorphisms after Ocufolin™ Administration.
Liu Z, Jiang H, Townsend JH, Wang J. Liu Z, et al. Microvasc Res. 2020 Nov;132:104066. doi: 10.1016/j.mvr.2020.104066. Epub 2020 Aug 27. Microvasc Res. 2020. PMID: 32860770 Free PMC article.
PURPOSE: To investigate conjunctival microvascular responses in patients with mild diabetic retinopathy (MDR) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms (D + PM) after administration of Ocufolin, a medical food containing 900 mug l-methylfolate (levomefolate …
PURPOSE: To investigate conjunctival microvascular responses in patients with mild diabetic retinopathy (MDR) and methylenetetrahydrofolate …
Folate status and homocysteine levels during a 24-week oral administration of a folate-containing oral contraceptive: a randomized, double-blind, active-controlled, parallel-group, US-based multicenter study.
Bart S Sr, Marr J, Diefenbach K, Trummer D, Sampson-Landers C. Bart S Sr, et al. Contraception. 2012 Jan;85(1):42-50. doi: 10.1016/j.contraception.2011.05.013. Epub 2011 Jul 13. Contraception. 2012. PMID: 22067790 Clinical Trial.
STUDY DESIGN: In this randomized, double-blind, multicenter US-based study, women (18-40 years) received 24 weeks (six cycles) of EE/drsp/levomefolate calcium or EE/drsp for 24 days followed by 4 days of levomefolate calcium alone or placebo, respectiv …
STUDY DESIGN: In this randomized, double-blind, multicenter US-based study, women (18-40 years) received 24 weeks (six cycles) of EE/drsp/ …
A pilot study to assess the effect of a three-month vitamin supplementation containing L-methylfolate on systemic homocysteine plasma concentrations and retinal blood flow in patients with diabetes.
Schmidl D, Howorka K, Szegedi S, Stjepanek K, Puchner S, Bata A, Scheschy U, Aschinger G, Werkmeister RM, Schmetterer L, Garhofer G. Schmidl D, et al. Mol Vis. 2020 Apr 24;26:326-333. eCollection 2020. Mol Vis. 2020. PMID: 32355442 Free PMC article.
METHODS: Twenty-four patients with diabetes received a dietary supplement (Oculofolin, Aprofol AG, Switzerland) containing 900 g L-methylfolate (levomefolate calcium or [6S]-5-methyltetrahydrofolic acid, calcium salt), methylcobalamin, and other ingredients for thre …
METHODS: Twenty-four patients with diabetes received a dietary supplement (Oculofolin, Aprofol AG, Switzerland) containing 900 g L-methylfol …
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