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Page 1
The stroke risk gene Foxf2 maintains brain endothelial cell function via Tie2 signaling.
Todorov-Völgyi K, González-Gallego J, Müller SA, Todorov MI, Seker FB, Frerich S, Cernilogar FM, Schröger L, Malik R, Cao J, Llovera G, Roth S, Schillinger U, Schifferer M, Reyahi A, Crusius D, Pedro LD, Simons M, Carlsson P, Ertürk A, Liesz A, Schotta G, Plesnila N, Lichtenthaler SF, Paquet D, Dichgans M. Todorov-Völgyi K, et al. Among authors: liesz a. Nat Neurosci. 2025 Dec 15. doi: 10.1038/s41593-025-02136-5. Online ahead of print. Nat Neurosci. 2025. PMID: 41398477
Preclinical Ischemic Stroke Multicenter Trials (PRISM) Collective Statement: Opportunities, Challenges, and Recommendations for a New Era.
Ayata C, Bath PM, Planas AM, Allan SM, Boltze J, Cabeen RP, Gibson CL, Cipolla MJ, Diniz MA, Fumagalli S, Hyder F, Koehler RC, Liesz A, McCann SK, Magnus T, McCullough LD, Sena ES, Beretta S, Aronowski J, Bosetti F, Wright CB, Lyden PD, Sansing LH. Ayata C, et al. Among authors: liesz a. Stroke. 2026 Jan;57(1):e12-e40. doi: 10.1161/STROKEAHA.125.052056. Epub 2025 Sep 11. Stroke. 2026. PMID: 40931817 Free PMC article. Review.
Most prominent challenges in translational neuroscience and strategic solutions to bridge the gaps: Perspectives from an editorial board interrogation.
Hermann DM, Bacigaluppi M, Bassetti CL, Bassotti G, Boltze J, Chan A, Dalkara T, Denes A, Diez-Tejedor E, Dodel R, Doeppner TR, Dzyubenko E, ElAli A, Fulop T, Gerhard A, Giebel B, Gronewold J, Gunzer M, Heinbockel T, Huang K, Iriti M, Karnath HO, Trenite KN, Kilic E, Lanza G, Liesz A, Magnus TU, Mandrioli J, Mohamud-Yusuf A, Müller T, Pan S, Peruzzotti-Jametti L, Pluchino S, Pluta R, Popa-Wagner A, Rezayof A, Seghier ML, Shu X, Singh V, Sipilä J, Slevin M, Tang Y, Tsivgoulis G, Varrassi G, Wang C, Yilmaz B, Zaki MS, Zhang J. Hermann DM, et al. Among authors: liesz a. Explor Neurosci. 2025;4:1006106. doi: 10.37349/en.2025.1006106. Epub 2025 Aug 12. Explor Neurosci. 2025. PMID: 40856238 Free PMC article.
TGFα controls checkpoints in CNS resident and infiltrating immune cells to promote resolution of inflammation.
Lößlein L, Linnerbauer M, Zuber F, Tsaktanis T, Vandrey O, Peter A, Panier F, Zissler J, Riekher V, Bäuerle T, Hanspach J, Laun FB, Nagel L, Mészáros L, Zunke F, Winkler J, Naumann UJ, Schwingen N, Neumaier E, Liesz A, Quintana F, Rothhammer V. Lößlein L, et al. Among authors: liesz a. Nat Commun. 2025 Jun 19;16(1):5344. doi: 10.1038/s41467-025-60363-7. Nat Commun. 2025. PMID: 40537468 Free PMC article.
Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19.
Fekete R, Simats A, Bíró E, Pósfai B, Cserép C, Schwarcz AD, Szabadits E, Környei Z, Tóth K, Fichó E, Szalma J, Vida S, Kellermayer A, Dávid C, Acsády L, Kontra L, Silvestre-Roig C, Moldvay J, Fillinger J, Csikász-Nagy A, Hortobágyi T, Liesz A, Benkő S, Dénes Á. Fekete R, et al. Among authors: liesz a. Nat Neurosci. 2025 Mar;28(3):558-576. doi: 10.1038/s41593-025-01871-z. Epub 2025 Mar 6. Nat Neurosci. 2025. PMID: 40050441 Free PMC article.
A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis.
Asare Y, Yan G, Schlegl C, Prestel M, van der Vorst EPC, Teunissen AJP, Aronova A, Tosato F, Naser N, Caputo J, Prevot G, Azzun A, Wefers B, Wurst W, Schneider M, Forne I, Bidzhekov K, Naumann R, van der Laan SW, Brandhofer M, Cao J, Roth S, Malik R, Tiedt S, Mulder WJM, Imhof A, Liesz A, Weber C, Bernhagen J, Dichgans M. Asare Y, et al. Among authors: liesz a. Immunity. 2025 Mar 11;58(3):555-567.e9. doi: 10.1016/j.immuni.2025.01.003. Epub 2025 Jan 28. Immunity. 2025. PMID: 39879983 Free article.
Net Benefit of Early Anticoagulation for Stroke With Atrial Fibrillation: Post Hoc Analysis of the ELAN Randomized Clinical Trial.
Polymeris AA, Branca M, Sylaja PN, Sandset EC, de Sousa DA, Thomalla G, Paciaroni M, Gattringer T, Strbian D, Trelle S, Michel P, Nedeltchev K, Bonati LH, Ntaios G, Koga M, Gdovinova Z, Lemmens R, Bornstein NM, Kelly P, Goeldlin MB, Abend S, Selim M, Katan M, Horvath T, Dawson J, Fischer U; ELAN Investigators. Polymeris AA, et al. JAMA Netw Open. 2025 Jan 2;8(1):e2456307. doi: 10.1001/jamanetworkopen.2024.56307. JAMA Netw Open. 2025. PMID: 39874037 Free PMC article. Clinical Trial.
RNase T2 restricts TLR13-mediated autoinflammation in vivo.
Gomez-Diaz C, Greulich W, Wefers B, Wang M, Bolsega S, Effern M, Varga DP, Han Z, Chen M, Bérouti M, Leonardi N, Schillinger U, Holzmann B, Liesz A, Roers A, Hölzel M, Basic M, Wurst W, Hornung V. Gomez-Diaz C, et al. Among authors: liesz a. J Exp Med. 2025 Mar 3;222(3):e20241424. doi: 10.1084/jem.20241424. Epub 2025 Jan 24. J Exp Med. 2025. PMID: 39853306
Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning.
Luo J, Molbay M, Chen Y, Horvath I, Kadletz K, Kick B, Zhao S, Al-Maskari R, Singh I, Ali M, Bhatia HS, Minde DP, Negwer M, Hoeher L, Calandra GM, Groschup B, Su J, Kimna C, Rong Z, Galensowske N, Todorov MI, Jeridi D, Ohn TL, Roth S, Simats A, Singh V, Khalin I, Pan C, Arús BA, Bruns OT, Zeidler R, Liesz A, Protzer U, Plesnila N, Ussar S, Hellal F, Paetzold J, Elsner M, Dietz H, Erturk A. Luo J, et al. Among authors: liesz a. Nat Biotechnol. 2025 Dec;43(12):2009-2022. doi: 10.1038/s41587-024-02528-1. Epub 2025 Jan 14. Nat Biotechnol. 2025. PMID: 39809933 Free PMC article.
Multicentre prospective, randomised open-label, endpoint-blinded study to evaluate the safety and efficacy of propranolol for the prevention of stroke-associated pneumonia in patients with intracerebral haemorrhage (PROCHASE): rationale and design.
Gao B, Shi K, Pan Y, Ge S, Liu Y, Yan J, Liesz A, Meisel A, Qu Y, Zhao X, Shi FD. Gao B, et al. Among authors: liesz a. Stroke Vasc Neurol. 2025 Aug 26;10(4):520-525. doi: 10.1136/svn-2024-003630. Stroke Vasc Neurol. 2025. PMID: 39740854 Free PMC article.
Early vs Late Anticoagulation After Ischemic Stroke in Patients With Atrial Fibrillation and Covert Brain Infarcts.
Kneihsl M, Hakim A, Goeldlin MB, Meinel TR, Branca M, Rohner R, Fenzl S, Abend S, Shim GC, Gumbinger C, Zhang L, Kristoffersen ES, Desfontaines P, Vanacker P, Alonso A, Poli S, Nunes AP, Caracciolo NG, Gattringer T, Kahles T, Giudici D, Demeestere J, Dawson J, Fischer U; ELAN investigators. Kneihsl M, et al. Neurology. 2025 Jan 14;104(1):e210157. doi: 10.1212/WNL.0000000000210157. Epub 2024 Dec 19. Neurology. 2025. PMID: 39700448 Clinical Trial.
Myeloid cell-specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease.
Dinkel L, Hummel S, Zenatti V, Malara M, Tillmann Y, Colombo A, Monasor LS, Suh JH, Logan T, Roth S, Paeger L, Hoffelner P, Bludau O, Schmidt A, Müller SA, Schifferer M, Nuscher B, Njavro JR, Prestel M, Bartos LM, Wind-Mark K, Slemann L, Hoermann L, Kunte ST, Gnörich J, Lindner S, Simons M, Herms J, Paquet D, Lichtenthaler SF, Bartenstein P, Franzmeier N, Liesz A, Grosche A, Bremova-Ertl T, Catarino C, Beblo S, Bergner C, Schneider SA, Strupp M, Di Paolo G, Brendel M, Tahirovic S. Dinkel L, et al. Among authors: liesz a. Sci Transl Med. 2024 Dec 4;16(776):eadl4616. doi: 10.1126/scitranslmed.adl4616. Epub 2024 Dec 4. Sci Transl Med. 2024. PMID: 39630885
Systemic determinants of brain health in ageing.
Smith EE, Biessels GJ, Gao V, Gottesman RF, Liesz A, Parikh NS, Iadecola C. Smith EE, et al. Among authors: liesz a. Nat Rev Neurol. 2024 Nov;20(11):647-659. doi: 10.1038/s41582-024-01016-z. Epub 2024 Oct 7. Nat Rev Neurol. 2024. PMID: 39375564 Free PMC article. Review.
Stroke of Consistency: Streamlining Multicenter Protocols for Enhanced Reproducibility of Infarct Volumes in Preclinical Stroke Research.
Llovera G, Langhauser F, Isla Cainzos S, Hoppen M, Abberger H, Mohamud Yusuf A, Mencl S, Heindl S, Ricci A, Haupeltshofer S, Kuchenbecker-Pöls L, Gunzer M, Hansen W, Hermann DM, Gelderblom M, Schmidt-Pogoda A, Minnerup J, Kleinschnitz C, Magnus T, Liesz A. Llovera G, et al. Among authors: liesz a. Stroke. 2024 Oct;55(10):2522-2527. doi: 10.1161/STROKEAHA.124.047232. Epub 2024 Sep 24. Stroke. 2024. PMID: 39315830
Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer's disease.
Zatcepin A, Gnörich J, Rauchmann BS, Bartos LM, Wagner S, Franzmeier N, Malpetti M, Xiang X, Shi Y, Parhizkar S, Grosch M, Wind-Mark K, Kunte ST, Beyer L, Meyer C, Brösamle D, Wendeln AC, Osei-Sarpong C, Heindl S, Liesz A, Stoecklein S, Biechele G, Finze A, Eckenweber F, Lindner S, Rominger A, Bartenstein P, Willem M, Tahirovic S, Herms J, Buerger K, Simons M, Haass C, Rupprecht R, Riemenschneider MJ, Albert NL, Beyer M, Neher JJ, Paeger L, Levin J, Höglinger GU, Perneczky R, Ziegler SI, Brendel M. Zatcepin A, et al. Among authors: liesz a. Mol Neurodegener. 2024 Sep 5;19(1):64. doi: 10.1186/s13024-024-00752-6. Mol Neurodegener. 2024. PMID: 39238030 Free PMC article.
DNA-sensing inflammasomes cause recurrent atherosclerotic stroke.
Cao J, Roth S, Zhang S, Kopczak A, Mami S, Asare Y, Georgakis MK, Messerer D, Horn A, Shemer R, Jacqmarcq C, Picot A, Green JP, Schlegl C, Li X, Tomas L, Dutsch A, Liman TG, Endres M, Wernsdorf SR, Fürle C, Carofiglio O, Zhu J, Brough D; DEMDAS Study Group; Hornung V, Dichgans M, Vivien D, Schulz C, Dor Y, Tiedt S, Sager HB, Grosse GM, Liesz A. Cao J, et al. Among authors: liesz a. Nature. 2024 Sep;633(8029):433-441. doi: 10.1038/s41586-024-07803-4. Epub 2024 Aug 7. Nature. 2024. PMID: 39112714 Free PMC article.
Innate immune memory after brain injury drives inflammatory cardiac dysfunction.
Simats A, Zhang S, Messerer D, Chong F, Beşkardeş S, Chivukula AS, Cao J, Besson-Girard S, Montellano FA, Morbach C, Carofiglio O, Ricci A, Roth S, Llovera G, Singh R, Chen Y, Filser S, Plesnila N, Braun C, Spitzer H, Gokce O, Dichgans M, Heuschmann PU, Hatakeyama K, Beltrán E, Clauss S, Bonev B, Schulz C, Liesz A. Simats A, et al. Among authors: liesz a. Cell. 2024 Aug 22;187(17):4637-4655.e26. doi: 10.1016/j.cell.2024.06.028. Epub 2024 Jul 22. Cell. 2024. PMID: 39043180 Free article.
T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.
Kedia S, Ji H, Feng R, Androvic P, Spieth L, Liu L, Franz J, Zdiarstek H, Anderson KP, Kaboglu C, Liu Q, Mattugini N, Cherif F, Prtvar D, Cantuti-Castelvetri L, Liesz A, Schifferer M, Stadelmann C, Tahirovic S, Gokce O, Simons M. Kedia S, et al. Among authors: liesz a. Nat Neurosci. 2024 Aug;27(8):1468-1474. doi: 10.1038/s41593-024-01682-8. Epub 2024 Jun 27. Nat Neurosci. 2024. PMID: 38937583 Free PMC article.
Early vs Late Anticoagulation in Minor, Moderate, and Major Ischemic Stroke With Atrial Fibrillation: Post Hoc Analysis of the ELAN Randomized Clinical Trial.
Goeldlin MB, Hakim A, Branca M, Abend S, Kneihsl M, Valenzuela Pinilla W, Fenzl S, Rezny-Kasprzak B, Rohner R, Strbian D, Paciaroni M, Thomalla G, Michel P, Nedeltchev K, Gattringer T, Sandset EC, Bonati L, Aguiar de Sousa D, Sylaja PN, Ntaios G, Koga M, Gdovinova Z, Lemmens R, Bornstein NM, Kelly P, Katan M, Horvath T, Dawson J, Fischer U; ELAN Investigators. Goeldlin MB, et al. JAMA Neurol. 2024 Jul 1;81(7):693-702. doi: 10.1001/jamaneurol.2024.1450. JAMA Neurol. 2024. PMID: 38805207 Free PMC article. Clinical Trial.
Inhaled nitric oxide suppresses neuroinflammation in experimental ischemic stroke.
Sienel RI, Mamrak U, Biller J, Roth S, Zellner A, Parakaw T, Khambata RS, Liesz A, Haffner C, Ahluwalia A, Seker BF, Plesnila N. Sienel RI, et al. Among authors: liesz a. J Neuroinflammation. 2023 Dec 15;20(1):301. doi: 10.1186/s12974-023-02988-3. J Neuroinflammation. 2023. PMID: 38102677 Free PMC article.
Pre-stroke exercise does not reduce atrophy in healthy young adult mice.
Geiseler SJ, Phan KD, Brox C, Nguyen TD, Tartanoglu C, Doosje HL, Christiansen CL, Liesz A, Morland C. Geiseler SJ, et al. Among authors: liesz a. Neurosci Lett. 2023 Sep 25;814:137447. doi: 10.1016/j.neulet.2023.137447. Epub 2023 Aug 20. Neurosci Lett. 2023. PMID: 37604388 Free article.
Distinct molecular profiles of skull bone marrow in health and neurological disorders.
Kolabas ZI, Kuemmerle LB, Perneczky R, Förstera B, Ulukaya S, Ali M, Kapoor S, Bartos LM, Büttner M, Caliskan OS, Rong Z, Mai H, Höher L, Jeridi D, Molbay M, Khalin I, Deligiannis IK, Negwer M, Roberts K, Simats A, Carofiglio O, Todorov MI, Horvath I, Ozturk F, Hummel S, Biechele G, Zatcepin A, Unterrainer M, Gnörich J, Roodselaar J, Shrouder J, Khosravani P, Tast B, Richter L, Díaz-Marugán L, Kaltenecker D, Lux L, Chen Y, Zhao S, Rauchmann BS, Sterr M, Kunze I, Stanic K, Kan VWY, Besson-Girard S, Katzdobler S, Palleis C, Schädler J, Paetzold JC, Liebscher S, Hauser AE, Gokce O, Lickert H, Steinke H, Benakis C, Braun C, Martinez-Jimenez CP, Buerger K, Albert NL, Höglinger G, Levin J, Haass C, Kopczak A, Dichgans M, Havla J, Kümpfel T, Kerschensteiner M, Schifferer M, Simons M, Liesz A, Krahmer N, Bayraktar OA, Franzmeier N, Plesnila N, Erener S, Puelles VG, Delbridge C, Bhatia HS, Hellal F, Elsner M, Bechmann I, Ondruschka B, Brendel M, Theis FJ, Erturk A. Kolabas ZI, et al. Among authors: liesz a. Cell. 2023 Aug 17;186(17):3706-3725.e29. doi: 10.1016/j.cell.2023.07.009. Epub 2023 Aug 9. Cell. 2023. PMID: 37562402 Free PMC article.
Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo.
Riemenschneider H, Simonetti F, Sheth U, Katona E, Roth S, Hutten S, Farny D, Michaelsen M, Nuscher B, Schmidt MK, Flatley A, Schepers A, Gruijs da Silva LA, Zhou Q, Klopstock T, Liesz A, Arzberger T, Herms J, Feederle R, Gendron TF, Dormann D, Edbauer D. Riemenschneider H, et al. Among authors: liesz a. Acta Neuropathol Commun. 2023 Jul 11;11(1):112. doi: 10.1186/s40478-023-01592-z. Acta Neuropathol Commun. 2023. PMID: 37434215 Free PMC article.
Early versus Later Anticoagulation for Stroke with Atrial Fibrillation.
Fischer U, Koga M, Strbian D, Branca M, Abend S, Trelle S, Paciaroni M, Thomalla G, Michel P, Nedeltchev K, Bonati LH, Ntaios G, Gattringer T, Sandset EC, Kelly P, Lemmens R, Sylaja PN, Aguiar de Sousa D, Bornstein NM, Gdovinova Z, Yoshimoto T, Tiainen M, Thomas H, Krishnan M, Shim GC, Gumbinger C, Vehoff J, Zhang L, Matsuzono K, Kristoffersen E, Desfontaines P, Vanacker P, Alonso A, Yakushiji Y, Kulyk C, Hemelsoet D, Poli S, Paiva Nunes A, Caracciolo N, Slade P, Demeestere J, Salerno A, Kneihsl M, Kahles T, Giudici D, Tanaka K, Räty S, Hidalgo R, Werring DJ, Göldlin M, Arnold M, Ferrari C, Beyeler S, Fung C, Weder BJ, Tatlisumak T, Fenzl S, Rezny-Kasprzak B, Hakim A, Salanti G, Bassetti C, Gralla J, Seiffge DJ, Horvath T, Dawson J; ELAN Investigators. Fischer U, et al. N Engl J Med. 2023 Jun 29;388(26):2411-2421. doi: 10.1056/NEJMoa2303048. Epub 2023 May 24. N Engl J Med. 2023. PMID: 37222476 Free article. Clinical Trial.
T cells modulate the microglial response to brain ischemia.
Benakis C, Simats A, Tritschler S, Heindl S, Besson-Girard S, Llovera G, Pinkham K, Kolz A, Ricci A, Theis FJ, Bittner S, Gökce Ö, Peters A, Liesz A. Benakis C, et al. Among authors: liesz a. Elife. 2022 Dec 13;11:e82031. doi: 10.7554/eLife.82031. Elife. 2022. PMID: 36512388 Free PMC article.
Immunity in Stroke: The Next Frontier.
Li T, Liesz A. Li T, et al. Among authors: liesz a. Thromb Haemost. 2022 Sep;122(9):1454-1460. doi: 10.1055/s-0042-1748890. Epub 2022 Jun 10. Thromb Haemost. 2022. PMID: 35688450 Free article.
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency.
Reifschneider A, Robinson S, van Lengerich B, Gnörich J, Logan T, Heindl S, Vogt MA, Weidinger E, Riedl L, Wind K, Zatcepin A, Pesämaa I, Haberl S, Nuscher B, Kleinberger G, Klimmt J, Götzl JK, Liesz A, Bürger K, Brendel M, Levin J, Diehl-Schmid J, Suh J, Di Paolo G, Lewcock JW, Monroe KM, Paquet D, Capell A, Haass C. Reifschneider A, et al. Among authors: liesz a. EMBO J. 2022 Feb 15;41(4):e109108. doi: 10.15252/embj.2021109108. Epub 2022 Jan 12. EMBO J. 2022. PMID: 35019161 Free PMC article.
Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges.
Schafflick D, Wolbert J, Heming M, Thomas C, Hartlehnert M, Börsch AL, Ricci A, Martín-Salamanca S, Li X, Lu IN, Pawlak M, Minnerup J, Strecker JK, Seidenbecher T, Meuth SG, Hidalgo A, Liesz A, Wiendl H, Meyer Zu Horste G. Schafflick D, et al. Among authors: liesz a. Nat Neurosci. 2021 Sep;24(9):1225-1234. doi: 10.1038/s41593-021-00880-y. Epub 2021 Jul 12. Nat Neurosci. 2021. PMID: 34253922
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition.
Colombo AV, Sadler RK, Llovera G, Singh V, Roth S, Heindl S, Sebastian Monasor L, Verhoeven A, Peters F, Parhizkar S, Kamp F, Gomez de Aguero M, MacPherson AJ, Winkler E, Herms J, Benakis C, Dichgans M, Steiner H, Giera M, Haass C, Tahirovic S, Liesz A. Colombo AV, et al. Among authors: liesz a. Elife. 2021 Apr 13;10:e59826. doi: 10.7554/eLife.59826. Elife. 2021. PMID: 33845942 Free PMC article.
Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade.
Roth S, Cao J, Singh V, Tiedt S, Hundeshagen G, Li T, Boehme JD, Chauhan D, Zhu J, Ricci A, Gorka O, Asare Y, Yang J, Lopez MS, Rehberg M, Bruder D, Zhang S, Groß O, Dichgans M, Hornung V, Liesz A. Roth S, et al. Among authors: liesz a. Immunity. 2021 Apr 13;54(4):648-659.e8. doi: 10.1016/j.immuni.2021.02.004. Epub 2021 Mar 4. Immunity. 2021. PMID: 33667383 Free article.
Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability.
Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RTA, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M. Asare Y, et al. Among authors: liesz a. Circ Res. 2020 Aug 28;127(6):811-823. doi: 10.1161/CIRCRESAHA.120.316743. Epub 2020 Jun 17. Circ Res. 2020. PMID: 32546048 Free article.
Short-Chain Fatty Acids Improve Poststroke Recovery via Immunological Mechanisms.
Sadler R, Cramer JV, Heindl S, Kostidis S, Betz D, Zuurbier KR, Northoff BH, Heijink M, Goldberg MP, Plautz EJ, Roth S, Malik R, Dichgans M, Holdt LM, Benakis C, Giera M, Stowe AM, Liesz A. Sadler R, et al. Among authors: liesz a. J Neurosci. 2020 Jan 29;40(5):1162-1173. doi: 10.1523/JNEUROSCI.1359-19.2019. Epub 2019 Dec 30. J Neurosci. 2020. PMID: 31889008 Free PMC article.
Microglia monitor and protect neuronal function through specialized somatic purinergic junctions.
Cserép C, Pósfai B, Lénárt N, Fekete R, László ZI, Lele Z, Orsolits B, Molnár G, Heindl S, Schwarcz AD, Ujvári K, Környei Z, Tóth K, Szabadits E, Sperlágh B, Baranyi M, Csiba L, Hortobágyi T, Maglóczky Z, Martinecz B, Szabó G, Erdélyi F, Szipőcs R, Tamkun MM, Gesierich B, Duering M, Katona I, Liesz A, Tamás G, Dénes Á. Cserép C, et al. Among authors: liesz a. Science. 2020 Jan 31;367(6477):528-537. doi: 10.1126/science.aax6752. Epub 2019 Dec 12. Science. 2020. PMID: 31831638
The microbiome-gut-brain axis in acute and chronic brain diseases.
Benakis C, Martin-Gallausiaux C, Trezzi JP, Melton P, Liesz A, Wilmes P. Benakis C, et al. Among authors: liesz a. Curr Opin Neurobiol. 2020 Apr;61:1-9. doi: 10.1016/j.conb.2019.11.009. Epub 2019 Dec 6. Curr Opin Neurobiol. 2020. PMID: 31812830 Free article. Review.
The vascular side of Alzheimer's disease.
Liesz A. Liesz A. Science. 2019 Jul 19;365(6450):223-224. doi: 10.1126/science.aay2720. Science. 2019. PMID: 31320524 No abstract available.
Fourth European stroke science workshop.
Debette S, Strbian D, Wardlaw JM, van der Worp HB, Rinkel G, Caso V, Dichgans M; European Stroke Science Workshop Presenters and Co-convenors. Debette S, et al. Eur Stroke J. 2018 Sep;3(3):206-219. doi: 10.1177/2396987318774443. Epub 2018 May 24. Eur Stroke J. 2018. PMID: 31009021 Free PMC article.
Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections.
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Recent progress in translational research on neurovascular and neurodegenerative disorders.
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Inadequate food and water intake determine mortality following stroke in mice.
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TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance.
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Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia.
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DAMP signaling is a key pathway inducing immune modulation after brain injury.
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