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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 1
1953 5
1954 2
1955 4
1956 11
1957 15
1958 11
1959 4
1960 10
1961 8
1962 10
1963 31
1964 50
1965 35
1966 34
1967 55
1968 44
1969 57
1970 50
1971 72
1972 90
1973 94
1974 93
1975 127
1976 125
1977 155
1978 155
1979 142
1980 146
1981 145
1982 136
1983 149
1984 160
1985 173
1986 171
1987 183
1988 153
1989 155
1990 165
1991 150
1992 133
1993 143
1994 126
1995 100
1996 108
1997 130
1998 96
1999 120
2000 108
2001 132
2002 108
2003 133
2004 119
2005 158
2006 107
2007 141
2008 120
2009 130
2010 162
2011 135
2012 149
2013 158
2014 154
2015 162
2016 170
2017 156
2018 176
2019 154
2020 174
2021 202
2022 192
2023 185
2024 179
2025 194
2026 90

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7,926 results

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Page 1
Primary hypothyroidism and quality of life.
Hegedüs L, Bianco AC, Jonklaas J, Pearce SH, Weetman AP, Perros P. Hegedüs L, et al. Nat Rev Endocrinol. 2022 Apr;18(4):230-242. doi: 10.1038/s41574-021-00625-8. Epub 2022 Jan 18. Nat Rev Endocrinol. 2022. PMID: 35042968 Free PMC article. Review.
Since then, no major innovation has emerged for the treatment of hypothyroidism. The biochemical definition of subclinical hypothyroidism is a matter of debate. ...Levothyroxine substitution improves, but does not always normalize, QOL, especially for individuals wi …
Since then, no major innovation has emerged for the treatment of hypothyroidism. The biochemical definition of subclinical hypothy …
Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism.
Shakir MKM, Brooks DI, McAninch EA, Fonseca TL, Mai VQ, Bianco AC, Hoang TD. Shakir MKM, et al. J Clin Endocrinol Metab. 2021 Oct 21;106(11):e4400-e4413. doi: 10.1210/clinem/dgab478. J Clin Endocrinol Metab. 2021. PMID: 34185829 Free PMC article. Clinical Trial.
INTRODUCTION: Studies comparing levothyroxine (LT4) therapy with LT4 + liothyronine (LT3) or desiccated thyroid extract (DTE) did not detect consistent superiority of either treatment. Here, we investigated these therapies, focusing on the whole group of LT4-treated hyp …
INTRODUCTION: Studies comparing levothyroxine (LT4) therapy with LT4 + liothyronine (LT3) or desiccated thyroid extract (DTE) did not …
Emerging Therapies in Hypothyroidism.
Bianco AC. Bianco AC. Annu Rev Med. 2024 Jan 29;75:307-319. doi: 10.1146/annurev-med-060622-101007. Epub 2023 Sep 22. Annu Rev Med. 2024. PMID: 37738506 Free PMC article. Review.
Levothyroxine (LT4) is effective for most patients with hypothyroidism. However, a minority of the patients remain symptomatic despite the normalization of serum thyrotropin levels. Randomized clinical trials including all types of patients with hypothyroidism revea …
Levothyroxine (LT4) is effective for most patients with hypothyroidism. However, a minority of the patients remain symptomatic despit …
Treatment of Hypothyroidism That Contains Liothyronine is Associated With Reduced Risk of Dementia and Mortality.
Beltrão FEL, Carvalhal G, Meneghini V, Matos DAR, Beltrão DCA, Andrade BARM, Beltrão FNL, Ramos HE, Ribeiro MO, Golovko G, Ettleson MD, Bianco AC. Beltrão FEL, et al. J Clin Endocrinol Metab. 2026 Jan 21;111(2):561-571. doi: 10.1210/clinem/dgaf367. J Clin Endocrinol Metab. 2026. PMID: 40579157
Observational studies link hypothyroidism to higher dementia rates; the role of LT4 plus T3 therapies remains uncertain. ...A parallel systematic review and meta-analysis of 12 studies evaluated dementia risk in hypothyroidism. RESULTS: Patients with hypothyroidi …
Observational studies link hypothyroidism to higher dementia rates; the role of LT4 plus T3 therapies remains uncertain. ...A paralle …
Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document.
Jonklaas J, Bianco AC, Cappola AR, Celi FS, Fliers E, Heuer H, McAninch EA, Moeller LC, Nygaard B, Sawka AM, Watt T, Dayan CM. Jonklaas J, et al. Thyroid. 2021 Feb;31(2):156-182. doi: 10.1089/thy.2020.0720. Thyroid. 2021. PMID: 33276704 Free PMC article. Review.
Background: Fourteen clinical trials have not shown a consistent benefit of combination therapy with levothyroxine (LT4) and liothyronine (LT3). Despite the publication of these trials, combination therapy is widely used and patients reporting benefit continue to generate …
Background: Fourteen clinical trials have not shown a consistent benefit of combination therapy with levothyroxine (LT4) and liothyronine …
Optimal Thyroid Hormone Replacement.
Jonklaas J. Jonklaas J. Endocr Rev. 2022 Mar 9;43(2):366-404. doi: 10.1210/endrev/bnab031. Endocr Rev. 2022. PMID: 34543420 Free PMC article.
Hypothyroidism is a common endocrinopathy, and levothyroxine is frequently prescribed. Despite the basic tenets of initiating and adjusting levothyroxine being agreed on, there are many nuances and complexities to consistently maintaining euthyroidism. ...Monitoring for ad …
Hypothyroidism is a common endocrinopathy, and levothyroxine is frequently prescribed. Despite the basic tenets of initiating and adj …
Treatment Preferences in Patients With Hypothyroidism.
de Lima Beltrão FE, Carvalhal G, de Almeida Beltrão DC, de Lima Beltrão FE, Ribeiro MO, Ettleson MD, Ramos HE, Bianco AC. de Lima Beltrão FE, et al. J Clin Endocrinol Metab. 2025 Feb 18;110(3):887-900. doi: 10.1210/clinem/dgae651. J Clin Endocrinol Metab. 2025. PMID: 39290156 Free PMC article.
CONTEXT: Levothyroxine (L-T4) monotherapy is the standard of care for the treatment of hypothyroidism. A minority of L-T4-treated patients remain symptomatic and report better outcomes with combination therapy that contains liothyronine (L-T3) or with desiccated thy …
CONTEXT: Levothyroxine (L-T4) monotherapy is the standard of care for the treatment of hypothyroidism. A minority of L-T4-treated pat …
Role of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism.
Jonklaas J. Jonklaas J. Endocrinol Metab Clin North Am. 2022 Jun;51(2):243-263. doi: 10.1016/j.ecl.2021.12.003. Epub 2022 May 4. Endocrinol Metab Clin North Am. 2022. PMID: 35662440 Review.
Diverse causes potentially underlie decreased quality of life in biochemically euthyroid patients treated for hypothyroidism with levothyroxine. Once these contributing factors are addressed, if symptoms persist, there may be benefit to personalized use of combination ther …
Diverse causes potentially underlie decreased quality of life in biochemically euthyroid patients treated for hypothyroidism with lev …
Use of liothyronine (T3) in hypothyroidism: Joint British Thyroid Association/Society for endocrinology consensus statement.
Ahluwalia R, Baldeweg SE, Boelaert K, Chatterjee K, Dayan C, Okosieme O, Priestley J, Taylor P, Vaidya B, Zammitt N, Pearce SH. Ahluwalia R, et al. Clin Endocrinol (Oxf). 2023 Aug;99(2):206-216. doi: 10.1111/cen.14935. Epub 2023 Jun 5. Clin Endocrinol (Oxf). 2023. PMID: 37272400
Persistent symptoms in patients treated for hypothyroidism are common. Despite more than 20 years of debate, the use of liothyronine for this indication remains controversial, as numerous randomised trials have failed to show a benefit of treatment regimens that com …
Persistent symptoms in patients treated for hypothyroidism are common. Despite more than 20 years of debate, the use of liothyroni …
A feasibility double-blind trial of levothyroxine vs. levothyroxine-liothyronine in postsurgical hypothyroidism.
Phan GQ, Yavuz S, Stamatouli AM, Madan R, Chen S, Grover AC, Nilubol N, Bedoya P, Trankle C, Markley R, Abbate A, Celi FS. Phan GQ, et al. Front Endocrinol (Lausanne). 2025 Mar 10;16:1522753. doi: 10.3389/fendo.2025.1522753. eCollection 2025. Front Endocrinol (Lausanne). 2025. PMID: 40130156 Free PMC article. Clinical Trial.
CONTEXT: Despite normalization of Thyrotropin (TSH), some patients with hypothyroidism treated with Levothyroxine (LT4) report residual symptoms which may be attributable to loss of endogenous triiodothyronine (T3). OBJECTIVE: Feasibility trial LT4/liothyronine …
CONTEXT: Despite normalization of Thyrotropin (TSH), some patients with hypothyroidism treated with Levothyroxine (LT4) report residu …
7,926 results