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Liposomal glutathione outperforms plain glutathione in uptake, cell regeneration and systemic availability: evidence from cellular and human models.
Prasad KN, Chandrashekar C, Karthik Y, Vasantha GG, Phadnis S. Prasad KN, et al. Br J Nutr. 2026 Jan 21:1-8. doi: 10.1017/S0007114526106254. Online ahead of print. Br J Nutr. 2026. PMID: 41559937
This study aimed to compare the biological activity and systemic availability of a novel liposomal glutathione formulation (LipoDuo Glutathione) with plain glutathione using both in vitro cellular models and in vivo human pharmacokinetic …
This study aimed to compare the biological activity and systemic availability of a novel liposomal glutathione f …
Glutathione in redox homeostasis: Bridging molecular mechanisms, bioavailability constraints, and translational challenges in systemic therapeutics.
Carnib BL, Matos ERSB, Lage TM, Pedro IDR, Ecclissato MCD, Teixeira RL, Rosenbaum MC, Silva ACA, de Oliveira JM. Carnib BL, et al. Biomed Pharmacother. 2026 Aug 12;203:119817. doi: 10.1016/j.biopha.2026.119817. Online ahead of print. Biomed Pharmacother. 2026. PMID: 42585816 Review.
Glutathione (GSH) is a key intracellular thiol and a master regulator of redox homeostasis, playing a vital role in detoxification, mitochondrial function, and cellular signaling. ...However, the analysis highlights a persistent disconnect while fundamental research focuse …
Glutathione (GSH) is a key intracellular thiol and a master regulator of redox homeostasis, playing a vital role in detoxification, m …
Niosomal hesperidin ameliorates depression-induced behavioral, histological, and molecular alterations in the rat hippocampus.
Otarkhani M, Hatami H, Panahi Y, Jammal AA, Sadeghian R, Yavari S. Otarkhani M, et al. Biomed Pharmacother. 2025 Oct;191:118473. doi: 10.1016/j.biopha.2025.118473. Epub 2025 Aug 21. Biomed Pharmacother. 2025. PMID: 40845815 Free article.
Next, the Forced Swimming Test (FST) and the Sucrose Preference Test (SPT) were applied to assess Behavioral disorders. Finally, Glutathione peroxidase (GPX) levels, malondialdehyde (MDA), TRPM2, and TRPC1 gene expression, as well as histo-stereological studies, were measu …
Next, the Forced Swimming Test (FST) and the Sucrose Preference Test (SPT) were applied to assess Behavioral disorders. Finally, Glutathi …
Design of novel proliposome formulation for antioxidant peptide, glutathione with enhanced oral bioavailability and stability.
Byeon JC, Lee SE, Kim TH, Ahn JB, Kim DH, Choi JS, Park JS. Byeon JC, et al. Drug Deliv. 2019 Dec;26(1):216-225. doi: 10.1080/10717544.2018.1551441. Drug Deliv. 2019. PMID: 30843439 Free PMC article.
To develop proliposome formulations to improve the oral bioavailability of l-glutathione (GSH), GSH-loaded proliposomes were prepared using the granule method. ...In conclusion, the prepared GSH proliposomes enhanced the poor bioavailability of GSH and prolon …
To develop proliposome formulations to improve the oral bioavailability of l-glutathione (GSH), GSH-loaded proliposomes were p …
Polymer-engineered liposome-delivered Ebselen against tumor through GSH/H(2)O(2)-responsive disruption of redox homeostasis and direct p53 activation.
Yu W, Liu T, Yuan Z, Liu S, Zhang H, Yang J, Yang Q, Yang Y, Chen T. Yu W, et al. Biomaterials. 2026 Mar;326:123698. doi: 10.1016/j.biomaterials.2025.123698. Epub 2025 Sep 16. Biomaterials. 2026. PMID: 40992159
Ebselen (EbSe), an organic selenium-based compound with potential antitumor activity, faces great challenges of poor aqueous solubility, which impairs its bioavailability and exacerbates potential toxicity. Liposomes, as established clinical tools for delivering sma …
Ebselen (EbSe), an organic selenium-based compound with potential antitumor activity, faces great challenges of poor aqueous solubility, whi …
A Targeted Metabolomic Assessment of Oral Glutathione Bioavailability and Safety in Humans: A Randomized Crossover Clinical Trial.
Solnier J, Du M, Zhang Y, Roh YS, Kuo YC, Ibi A, Wood S, Hardy M, Gahler RJ, Chang C. Solnier J, et al. Antioxidants (Basel). 2026 Mar 11;15(3):354. doi: 10.3390/antiox15030354. Antioxidants (Basel). 2026. PMID: 41897500 Free PMC article.
This human pilot study aimed to evaluate the oral absorption and safety profile of a novel formulation of micellar glutathione (LipoMicel( ), LMG) compared with two commonly used dietary supplement forms: standard glutathione (STD) and liposomal glutathion …
This human pilot study aimed to evaluate the oral absorption and safety profile of a novel formulation of micellar glutathione (LipoM …
Enhanced oral bioavailability and in vivo antioxidant activity of chlorogenic acid via liposomal formulation.
Feng Y, Sun C, Yuan Y, Zhu Y, Wan J, Firempong CK, Omari-Siaw E, Xu Y, Pu Z, Yu J, Xu X. Feng Y, et al. Int J Pharm. 2016 Mar 30;501(1-2):342-9. doi: 10.1016/j.ijpharm.2016.01.081. Epub 2016 Feb 6. Int J Pharm. 2016. PMID: 26861689
In the present study, a formulation system consisting of cholesterol and phosphatidyl choline was used to prepare an effective chlorogenic acid-loaded liposome (CAL) with an improved oral bioavailability and an increased antioxidant activity. ...Collectively, these …
In the present study, a formulation system consisting of cholesterol and phosphatidyl choline was used to prepare an effective chlorogenic a …
Glutathione Therapy in Diseases: Challenges and Potential Solutions for Therapeutic Advancement.
Dehkordi HT, Ghasemi S. Dehkordi HT, et al. Curr Mol Med. 2024;24(10):1219-1230. doi: 10.2174/1566524023666230818142831. Curr Mol Med. 2024. PMID: 37594114 Review.
However, there are challenges in this field. Low bioavailability and poor stability of GSH limit its delivery to tissues, mainly brain tissue. ...The utilization of nano-materials and liposomes as potential new approaches to solving these issues is being considered. …
However, there are challenges in this field. Low bioavailability and poor stability of GSH limit its delivery to tissues, mainly brai …
Ebselen, a selenoorganic compound as glutathione peroxidase mimic.
Sies H. Sies H. Free Radic Biol Med. 1993 Mar;14(3):313-23. doi: 10.1016/0891-5849(93)90028-s. Free Radic Biol Med. 1993. PMID: 8458589 Review.
The selenoorganic compound ebselen, 2-phenyl-1,2-benzisoselenazol-3(2H)-one, exhibits activity as an enzyme mimic. The reaction catalyzed is that of a glutathione (GSH) peroxidase (i.e., the reduction of a hydroperoxide at the expense of thiol). ...The main point is that t …
The selenoorganic compound ebselen, 2-phenyl-1,2-benzisoselenazol-3(2H)-one, exhibits activity as an enzyme mimic. The reaction catalyzed is …
Cardioprotective effects of liposomal resveratrol in diabetic rats: unveiling antioxidant and anti-inflammatory benefits.
Alanazi AZ, Alqinyah M, Alhamed AS, Mohammed H, Raish M, Aljerian K, Alsabhan JF, Alhazzani K. Alanazi AZ, et al. Redox Rep. 2024 Dec;29(1):2416835. doi: 10.1080/13510002.2024.2416835. Epub 2024 Nov 4. Redox Rep. 2024. PMID: 39496097 Free PMC article.
There is evidence that natural phytochemicals, including resveratrol, a bioactive polyphenol, may be able to reduce oxidative stress and improve insulin sensitivity. However, resveratrol's limited bioavailability hampers its therapeutic effectiveness. By using liposomes …
There is evidence that natural phytochemicals, including resveratrol, a bioactive polyphenol, may be able to reduce oxidative stress and imp …
49 results