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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 1
1951 2
1952 1
1953 1
1954 2
1955 2
1956 2
1959 2
1960 2
1961 1
1962 2
1963 3
1964 5
1965 3
1966 10
1967 16
1968 57
1969 55
1970 92
1971 96
1972 103
1973 89
1974 97
1975 115
1976 118
1977 136
1978 111
1979 186
1980 127
1981 133
1982 148
1983 144
1984 153
1985 126
1986 149
1987 117
1988 138
1989 144
1990 133
1991 114
1992 114
1993 128
1994 106
1995 126
1996 135
1997 138
1998 154
1999 215
2000 187
2001 197
2002 184
2003 244
2004 226
2005 262
2006 283
2007 298
2008 265
2009 277
2010 266
2011 244
2012 280
2013 290
2014 306
2015 286
2016 331
2017 321
2018 295
2019 290
2020 211
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9,007 results
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Page 1
An Oldie but Goodie: Lithium in the Treatment of Bipolar Disorder through Neuroprotective and Neurotrophic Mechanisms.
Won E, Kim YK. Won E, et al. Int J Mol Sci. 2017 Dec 11;18(12):2679. doi: 10.3390/ijms18122679. Int J Mol Sci. 2017. PMID: 29232923 Free PMC article. Review.
Lithium has been used for the treatment of bipolar disorder (BD) for the last sixty or more years, and recent studies with more reliable designs and updated guidelines have recommended lithium to be the treatment of choice for acute manic, mixed and depressiv
Lithium has been used for the treatment of bipolar disorder (BD) for the last sixty or more years, and recent studies with mor
Lithium: still a major option in the management of bipolar disorder.
Licht RW. Licht RW. CNS Neurosci Ther. 2012 Mar;18(3):219-26. doi: 10.1111/j.1755-5949.2011.00260.x. Epub 2011 Jun 23. CNS Neurosci Ther. 2012. PMID: 22070642 Free PMC article. Review.
Additionally, the evidence was sought translated into the proper use of lithium in clinical practice. Lithium's antimanic efficacy has been convincingly demonstrated. ...For acute bipolar depression, results are conflicting. Recent maintenance trials h …
Additionally, the evidence was sought translated into the proper use of lithium in clinical practice. Lithium's antiman …
Free and Bound Therapeutic Lithium in Brain Signaling.
Dudev T, Mazmanian K, Weng WH, Grauffel C, Lim C. Dudev T, et al. Acc Chem Res. 2019 Oct 15;52(10):2960-2970. doi: 10.1021/acs.accounts.9b00389. Epub 2019 Sep 26. Acc Chem Res. 2019. PMID: 31556294 Review.
Lithium, a first-line therapy for bipolar disorder, is effective in preventing suicide and new depressive/manic episodes. Yet, how this beguilingly simple monocation with only two electrons could yield such profound therapeutic effects remains unclear. An in-depth u
Lithium, a first-line therapy for bipolar disorder, is effective in preventing suicide and new depressive/manic episodes. Yet,
Modeling Complex Neurological Diseases with Stem Cells: A Study of Bipolar Disorder.
Pernia CD, Nathan NH, Tobe BTD, Winquist AM, Sidman RL, Goshima Y, Snyder EY. Pernia CD, et al. Results Probl Cell Differ. 2018;66:265-282. doi: 10.1007/978-3-319-93485-3_12. Results Probl Cell Differ. 2018. PMID: 30209664
However, hiPSCs from BPD patients responsive to lithium have offered unique opportunities to discern lithium's mechanism of action and hence gain insight into BPD pathology. ...These data suggest that the "lithium response pathway" in BPD governs CRMP2 …
However, hiPSCs from BPD patients responsive to lithium have offered unique opportunities to discern lithium's mechanis …
Lithium in bipolar disorder: can drug concentrations predict therapeutic effect?
Sproule B. Sproule B. Clin Pharmacokinet. 2002;41(9):639-60. doi: 10.2165/00003088-200241090-00002. Clin Pharmacokinet. 2002. PMID: 12126457 Review.
The evidence is reviewed for effective serum lithium concentrations for the acute and prophylactic treatment of mania and depression in patients with bipolar disorder. ...Lithium doses and serum concentrations similar to those used to treat acute mania have b …
The evidence is reviewed for effective serum lithium concentrations for the acute and prophylactic treatment of mania and depression …
Lithium in the long-term treatment of bipolar disorders.
Kleindienst N, Greil W. Kleindienst N, et al. Eur Arch Psychiatry Clin Neurosci. 2003 Jun;253(3):120-5. doi: 10.1007/s00406-003-0429-2. Eur Arch Psychiatry Clin Neurosci. 2003. PMID: 12904975 Review.
Lithium efficacy is high and beyond reasonable doubt in classic manic-depressive illness. Bipolar patients presenting atypical features show a much poorer response rate to lithium. 2. ...Other factors limiting lithium efficacy in clinical practice (e.
Lithium efficacy is high and beyond reasonable doubt in classic manic-depressive illness. Bipolar patients presenting atypical
Timing of onset of lithium relapse prevention in bipolar disorder: evidence from randomised trials.
Taylor MJ. Taylor MJ. Br J Psychiatry. 2018 Nov;213(5):664-666. doi: 10.1192/bjp.2018.177. Epub 2018 Sep 24. Br J Psychiatry. 2018. PMID: 30246666
Lithium is widely prescribed, but the timing of key effects remains uncertain. The timing of onset of its relapse prevention effects is clarified by placebo-controlled randomised trials (3 studies, n = 1120). ...There is an early onset of lithium relapse prevention
Lithium is widely prescribed, but the timing of key effects remains uncertain. The timing of onset of its relapse prevention effects
Lithium.
el-Mallakh RS. el-Mallakh RS. Conn Med. 1990 Mar;54(3):115-26. Conn Med. 1990. PMID: 2182284 Review.
Lithium utility and toxicity are reviewed. Lithium continues to be the most useful agent available for the prophylaxis and treatment of bipolar illness. ...In internal medicine, lithium has proven useful in the prophylaxis of cluster headaches and in a
Lithium utility and toxicity are reviewed. Lithium continues to be the most useful agent available for the prophylaxis and tre
Inositol, lithium, and the brain.
Agranoff BW, Fisher SK. Agranoff BW, et al. Psychopharmacol Bull. 2001 Summer;35(3):5-18. Psychopharmacol Bull. 2001. PMID: 12397875 Review.
We review the inositol depletion hypothesis, which proposes that lithium's beneficial action in the treatment of bipolar disorder is attributable to its inhibition of the enzymatic breakdown of inositol phosphates to free inositol. ...We offer an alternative …
We review the inositol depletion hypothesis, which proposes that lithium's beneficial action in the treatment of bipolar
Is the prophylactic antidepressant efficacy of lithium in bipolar I disorder dependent on study design and lithium level?
Severus WE, Grunze H, Kleindienst N, Frangou S, Moeller HJ. Severus WE, et al. J Clin Psychopharmacol. 2005 Oct;25(5):457-62. doi: 10.1097/01.jcp.0000177550.13714.7a. J Clin Psychopharmacol. 2005. PMID: 16160621 Review.
In the 1970s, several randomized controlled trials demonstrated significant antimanic and antidepressant properties of lithium in the prophylactic treatment of bipolar disorder. ...Lithium's efficacy against manic relapse/recurrence appears rather robu …
In the 1970s, several randomized controlled trials demonstrated significant antimanic and antidepressant properties of lithium in the …
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