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177 results

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Page 1
Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure.
Lee WM, Hynan LS, Rossaro L, Fontana RJ, Stravitz RT, Larson AM, Davern TJ 2nd, Murray NG, McCashland T, Reisch JS, Robuck PR; Acute Liver Failure Study Group. Lee WM, et al. Gastroenterology. 2009 Sep;137(3):856-64, 864.e1. doi: 10.1053/j.gastro.2009.06.006. Epub 2009 Jun 12. Gastroenterology. 2009. PMID: 19524577 Free PMC article. Clinical Trial.
BACKGROUND & AIMS: N-acetylcysteine (NAC), an antidote for acetaminophen poisoning, might benefit patients with non-acetaminophen-related acute liver failure. ...The primary outcome was overall survival at 3 weeks. Secondary outcomes include …
BACKGROUND & AIMS: N-acetylcysteine (NAC), an antidote for acetaminophen poisoning, might benefit patients with non-acetam …
N-acetylcysteine in non-acetaminophen-induced acute liver failure: a systematic review and meta-analysis of prospective studies.
Amjad W, Thuluvath P, Mansoor M, Dutta A, Ali F, Qureshi W. Amjad W, et al. Prz Gastroenterol. 2022;17(1):9-16. doi: 10.5114/pg.2021.107797. Epub 2021 Jul 14. Prz Gastroenterol. 2022. PMID: 35371352 Free PMC article. Review.
The primary outcome was overall mortality. Secondary outcomes were transplant-free survival and length of hospital stay. ...CONCLUSIONS: The treatment of patients with acute liver failure with N-acetylcysteine improved transplant-f …
The primary outcome was overall mortality. Secondary outcomes were transplant-free survival and length of hospital stay …
Acute liver failure: Management update and prognosis.
Martínez-Martínez LM, Rosales-Sotomayor G, Jasso-Baltazar EA, Torres-Díaz JA, Aguirre-Villarreal D, Hurtado-Díaz de León I, Páez-Zayas VM, Sánchez-Cedillo A, Martínez-Vázquez SE, Tadeo-Espinoza HN, Guerrero-Cabrera JP, García-Alanis M, García-Juárez I. Martínez-Martínez LM, et al. Rev Gastroenterol Mex (Engl Ed). 2024 Jul-Sep;89(3):404-417. doi: 10.1016/j.rgmxen.2024.05.002. Epub 2024 Jul 20. Rev Gastroenterol Mex (Engl Ed). 2024. PMID: 39033039 Free article. Review.
Its pathophysiology and clinical course vary, depending on the cause of the primary liver injury, and can lead to high morbidity and mortality or the need for liver transplantation, despite available therapies. ...Survival has improved with supportive measure …
Its pathophysiology and clinical course vary, depending on the cause of the primary liver injury, and can lead to high morbidity and …
Role of N-acetylcysteine in non-acetaminophen-related acute liver failure: an updated meta-analysis and systematic review.
Walayat S, Shoaib H, Asghar M, Kim M, Dhillon S. Walayat S, et al. Ann Gastroenterol. 2021;34(2):235-240. doi: 10.20524/aog.2021.0571. Epub 2021 Jan 4. Ann Gastroenterol. 2021. PMID: 33654365 Free PMC article.
BACKGROUND: The American Association for the Study of Liver Diseases recommends that N-acetylcysteine (NAC) may be beneficial in non-acetaminophen-related drug-induced liver injury. ...The primary outcome was to compare the overall survival in t …
BACKGROUND: The American Association for the Study of Liver Diseases recommends that N-acetylcysteine (NAC) may be bene …
Acute liver failure.
Vasques F, Cavazza A, Bernal W. Vasques F, et al. Curr Opin Crit Care. 2022 Apr 1;28(2):198-207. doi: 10.1097/MCC.0000000000000923. Curr Opin Crit Care. 2022. PMID: 35142727 Review.
Specific coagulopathy profiles including an abnormal vWF/ADAMTS13 ratio may be associated with poor outcome and increased bleeding risk. Use of N-acetylcysteine in nonparacetamol-related cases remains unsupported by robust clinical evidence. ...Better prognos …
Specific coagulopathy profiles including an abnormal vWF/ADAMTS13 ratio may be associated with poor outcome and increased bleeding ri …
Interventions for paracetamol (acetaminophen) overdose.
Chiew AL, Gluud C, Brok J, Buckley NA. Chiew AL, et al. Cochrane Database Syst Rev. 2018 Feb 23;2(2):CD003328. doi: 10.1002/14651858.CD003328.pub3. Cochrane Database Syst Rev. 2018. PMID: 29473717 Free PMC article.
The most recent randomised clinical trials studied different acetylcysteine regimens, with the primary outcome being adverse events. It was unclear which acetylcysteine treatment protocol offered the best efficacy, as most trials were underpowered to look at …
The most recent randomised clinical trials studied different acetylcysteine regimens, with the primary outcome being adverse e …
N-acetylcysteine for non-paracetamol (acetaminophen)-related acute liver failure.
Siu JT, Nguyen T, Turgeon RD. Siu JT, et al. Cochrane Database Syst Rev. 2020 Dec 9;12(12):CD012123. doi: 10.1002/14651858.CD012123.pub2. Cochrane Database Syst Rev. 2020. PMID: 33294991 Free PMC article.
N-acetylcysteine has been successful in treating paracetamol-induced acute liver failure and reduces the risk of needing to undergo liver transplantation. ...AUTHORS' CONCLUSIONS: The available evidence is inconclusive regarding the effect of …
N-acetylcysteine has been successful in treating paracetamol-induced acute liver failure and reduces the risk of needin …
Acute Liver Failure.
Bunchorntavakul C, Reddy KR. Bunchorntavakul C, et al. Clin Liver Dis. 2017 Nov;21(4):769-792. doi: 10.1016/j.cld.2017.06.002. Epub 2017 Jul 29. Clin Liver Dis. 2017. PMID: 28987262 Review.
Acute liver failure (ALF) is a life-threatening condition of heterogeneous etiology. Outcomes are better with early recognition and prompt initiation of etiology-specific therapy, intensive care protocols, and liver transplantation (LT). ...Extracorpor …
Acute liver failure (ALF) is a life-threatening condition of heterogeneous etiology. Outcomes are better with early recognitio …
Systematic review and meta-analysis of the effect of N-acetylcysteine on outcomes after liver resection.
Koh A, Wong T, Adiamah A, Sanyal S. Koh A, et al. ANZ J Surg. 2024 Oct;94(10):1693-1701. doi: 10.1111/ans.19183. Epub 2024 Aug 5. ANZ J Surg. 2024. PMID: 39101362
BACKGROUND: N-Acetylcysteine (NAC) is a recognized antioxidative agent that facilitates the conjugation of toxic metabolites. In recent years, NAC has been routinely used to limit ischaemia-reperfusion injury in liver transplantation. There remains, ho …
BACKGROUND: N-Acetylcysteine (NAC) is a recognized antioxidative agent that facilitates the conjugation of toxic metabolites. …
Acetaminophen Toxicity.
Schaffer DH, Murray BP, Khazaeni B. Schaffer DH, et al. 2026 Mar 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. 2026 Mar 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. PMID: 28722946 Free Books & Documents.
Timely intervention is essential in preventing fulminant liver failure and the need for liver transplantation. Activated charcoal can be considered in the first 2 hours after an acute ingestion, although there are limited data supporting improved outcomes …
Timely intervention is essential in preventing fulminant liver failure and the need for liver transplantation. Activate …
177 results