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2,247 results

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Page 1
LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity.
Wei X, Zhang L, Yang Y, Hou Y, Xu Y, Wang Z, Su H, Han F, Han J, Liu P, Hu S, Koci MD, Sun X, Zhang C. Wei X, et al. Cell Rep. 2022 May 31;39(9):110880. doi: 10.1016/j.celrep.2022.110880. Cell Rep. 2022. PMID: 35649354 Free article.
However, as an anionic hydrophilic molecule, cGAMP is not inherently membrane permeable. Here, we show that LL-37, a human host defense peptide, can function as a transporter of cGAMP. LL-37 specifically binds cGAMP and efficiently delivers cGAMP into …
However, as an anionic hydrophilic molecule, cGAMP is not inherently membrane permeable. Here, we show that LL-37, a human hos …
Therapeutic Potential of Cathelicidin Peptide LL-37, an Antimicrobial Agent, in a Murine Sepsis Model.
Nagaoka I, Tamura H, Reich J. Nagaoka I, et al. Int J Mol Sci. 2020 Aug 19;21(17):5973. doi: 10.3390/ijms21175973. Int J Mol Sci. 2020. PMID: 32825174 Free PMC article. Review.
In different species of mammals, the cathelicidin family of antimicrobial peptides AMPs has been identified, and in humans, LL-37 is the only type of cathelicidin identified. LL-37 has many different biological activities, such as regulation of respons …
In different species of mammals, the cathelicidin family of antimicrobial peptides AMPs has been identified, and in humans, LL-37 …
Regulation of LL-37 in Bone and Periodontium Regeneration.
Chinipardaz Z, Zhong JM, Yang S. Chinipardaz Z, et al. Life (Basel). 2022 Sep 30;12(10):1533. doi: 10.3390/life12101533. Life (Basel). 2022. PMID: 36294968 Free PMC article. Review.
LL-37 also manifests other functions such as promoting wound healing, angiogenesis, cell differentiation, and modulating apoptosis. This review summarizes the current studies on the structure, expression, and function of LL-37 and highlights the contri …
LL-37 also manifests other functions such as promoting wound healing, angiogenesis, cell differentiation, and modulating apopt …
Antibiofilm properties of cathelicidin LL-37: an in-depth review.
Memariani H, Memariani M. Memariani H, et al. World J Microbiol Biotechnol. 2023 Feb 14;39(4):99. doi: 10.1007/s11274-023-03545-z. World J Microbiol Biotechnol. 2023. PMID: 36781570 Review.
Endogenous host defense peptides, such as the human cathelicidin LL-37, are being propounded as promising options for treating such infectious diseases. ...Undoubtedly, LL-37 can open up new windows of opportunity to prevent and treat obstinate biofilm …
Endogenous host defense peptides, such as the human cathelicidin LL-37, are being propounded as promising options for treating …
Antifungal properties of cathelicidin LL-37: current knowledge and future research directions.
Memariani M, Memariani H. Memariani M, et al. World J Microbiol Biotechnol. 2023 Dec 7;40(1):34. doi: 10.1007/s11274-023-03852-5. World J Microbiol Biotechnol. 2023. PMID: 38057654 Review.
Recent years have witnessed an explosion in knowledge on microbicidal activity of LL-37, the sole human cathelicidin. Herein, we provide a summary of the current understanding about antifungal properties of LL-37, with particular emphasis on its molecu …
Recent years have witnessed an explosion in knowledge on microbicidal activity of LL-37, the sole human cathelicidin. Herein, …
The Potential of Human Peptide LL-37 as an Antimicrobial and Anti-Biofilm Agent.
Ridyard KE, Overhage J. Ridyard KE, et al. Antibiotics (Basel). 2021 May 29;10(6):650. doi: 10.3390/antibiotics10060650. Antibiotics (Basel). 2021. PMID: 34072318 Free PMC article. Review.
While LL-37 has shown promising results, it has yet to receive regulatory approval as a peptide antibiotic. ...The possible methods to overcome these challenges, including immobilization techniques, LL-37 delivery systems, the development of LL- …
While LL-37 has shown promising results, it has yet to receive regulatory approval as a peptide antibiotic. ...The possible me …
Cathelicidin LL-37: A new important molecule in the pathophysiology of systemic lupus erythematosus.
Moreno-Angarita A, Aragón CC, Tobón GJ. Moreno-Angarita A, et al. J Transl Autoimmun. 2019 Dec 17;3:100029. doi: 10.1016/j.jtauto.2019.100029. eCollection 2020. J Transl Autoimmun. 2019. PMID: 32743514 Free PMC article. Review.
In this article, we reviewed the structure, function, and importance of LL-37 in innate immunity, as well as its biological plausibility in the pathophysiology of autoimmune diseases such as SLE. In this narrative review, we included primary journal articles describ …
In this article, we reviewed the structure, function, and importance of LL-37 in innate immunity, as well as its biological pl …
LL-37: Cathelicidin-related antimicrobial peptide with pleiotropic activity.
Fabisiak A, Murawska N, Fichna J. Fabisiak A, et al. Pharmacol Rep. 2016 Aug;68(4):802-8. doi: 10.1016/j.pharep.2016.03.015. Epub 2016 Apr 7. Pharmacol Rep. 2016. PMID: 27117377 Review.
Among them, defensins and cathelicidins could be found. LL-37, the sole human cathelicidin draws particular attention because of its outstanding abilities. In addition to being a broad spectrum antibiotic, LL-37 has potent chemotactic and immunomodulat …
Among them, defensins and cathelicidins could be found. LL-37, the sole human cathelicidin draws particular attention because …
Structural Plasticity of LL-37 Indicates Elaborate Functional Adaptation Mechanisms to Bacterial Target Structures.
Zeth K, Sancho-Vaello E. Zeth K, et al. Int J Mol Sci. 2021 May 14;22(10):5200. doi: 10.3390/ijms22105200. Int J Mol Sci. 2021. PMID: 34068993 Free PMC article. Review.
The human cathelicidin LL-37 is a multifunctional peptide of the human innate immune system. Among the various functions of LL-37, its antimicrobial activity is important in controlling the microorganisms of the human body. The target molecules of L …
The human cathelicidin LL-37 is a multifunctional peptide of the human innate immune system. Among the various functions of …
LL-37-dsRNA Complexes Modulate Immune Response via RIG-I in Oral Keratinocytes.
Kato H, Ohta K, Akagi M, Fukada S, Sakuma M, Naruse T, Nishi H, Shigeishi H, Takechi M, Aikawa T. Kato H, et al. Inflammation. 2023 Jun;46(3):808-823. doi: 10.1007/s10753-023-01787-5. Epub 2023 Feb 10. Inflammation. 2023. PMID: 36763254
In this study, we firstly investigated the effect of LL-37 on CXCL10 induced by DAMPs and PAMPs in immortalized oral keratinocytes, RT7. Furthermore, the effects of LL-37 on translocation of exogenous nucleic acids into cytoplasm as well as cytosolic r …
In this study, we firstly investigated the effect of LL-37 on CXCL10 induced by DAMPs and PAMPs in immortalized oral keratinoc …
2,247 results

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