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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 3
1947 2
1948 1
1949 2
1950 3
1951 3
1952 2
1953 1
1954 3
1955 5
1956 5
1957 3
1958 7
1960 4
1961 3
1962 4
1963 6
1964 1
1965 3
1966 10
1967 21
1968 20
1969 24
1970 31
1971 36
1972 35
1973 32
1974 28
1975 63
1976 66
1977 86
1978 87
1979 104
1980 133
1981 169
1982 199
1983 207
1984 268
1985 321
1986 352
1987 427
1988 521
1989 683
1990 819
1991 1017
1992 1245
1993 1450
1994 1780
1995 2122
1996 2352
1997 2643
1998 3119
1999 3545
2000 3990
2001 4463
2002 4663
2003 5123
2004 5670
2005 5993
2006 6600
2007 6861
2008 7237
2009 7527
2010 8090
2011 8452
2012 9041
2013 9586
2014 9924
2015 9932
2016 9759
2017 10268
2018 10079
2019 10209
2020 10594
2021 11056
2022 10338
2023 10039
2024 10732
2025 13891
2026 9247

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229,715 results

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Page 1
Specific localization and timing in neuronal signal transduction mediated by protein-lipid interactions.
Fivaz M, Meyer T. Fivaz M, et al. Neuron. 2003 Oct 9;40(2):319-30. doi: 10.1016/s0896-6273(03)00634-2. Neuron. 2003. PMID: 14556711 Free article. Review.
A large number of signaling proteins translocate from the cytosol to the plasma membrane in response to receptor and electrical stimuli. ...Here we discuss how diversity in lipid-based membrane anchoring and targeting motifs contributes to plasticity in neuronal signali …
A large number of signaling proteins translocate from the cytosol to the plasma membrane in response to receptor and electrical stimu …
Dynamic membrane patterning, signal localization and polarity in living cells.
Zamparo M, Chianale F, Tebaldi C, Cosentino-Lagomarsino M, Nicodemi M, Gamba A. Zamparo M, et al. Soft Matter. 2015 Feb 7;11(5):838-49. doi: 10.1039/c4sm02157f. Epub 2015 Jan 7. Soft Matter. 2015. PMID: 25563791 Review.
We review the molecular and physical aspects of the dynamic localization of signaling molecules on the plasma membranes of living cells. At the nanoscale, clusters of receptors and signaling proteins play an essential role in the processing of extracellular …
We review the molecular and physical aspects of the dynamic localization of signaling molecules on the plasma membranes of liv …
Integrin-mediated signal transduction.
Longhurst CM, Jennings LK. Longhurst CM, et al. Cell Mol Life Sci. 1998 Jun;54(6):514-26. doi: 10.1007/s000180050180. Cell Mol Life Sci. 1998. PMID: 9676571 Free PMC article. Review.
In addition, integrins interact with the cytoskeleton and through this process participate in cell migration, tissue organization, cell growth, haemostasis, inflammation, target recognition of lymphocytes and the differentiation of many cell types. Signals generated from l …
In addition, integrins interact with the cytoskeleton and through this process participate in cell migration, tissue organization, cell grow …
Paxillin interactions.
Turner CE. Turner CE. J Cell Sci. 2000 Dec;113 Pt 23:4139-40. doi: 10.1242/jcs.113.23.4139. J Cell Sci. 2000. PMID: 11069756 Review.
Focal adhesions form a structural link between the ECM and the actin cytoskeleton and are also important sites of signal transduction; their components propagate signals arising from the activation of integrins following their engagement with ECM prote …
Focal adhesions form a structural link between the ECM and the actin cytoskeleton and are also important sites of signal tr …
Studying signal compartmentation in adult cardiomyocytes.
Judina A, Gorelik J, Wright PT. Judina A, et al. Biochem Soc Trans. 2020 Feb 28;48(1):61-70. doi: 10.1042/BST20190247. Biochem Soc Trans. 2020. PMID: 32104883 Free PMC article. Review.
Multiple intra-cellular signalling pathways rely on calcium and 3'-5' cyclic adenosine monophosphate (cAMP) to act as secondary messengers. ...Active processes comprise the creation and destruction of signals, whereas passive processes comprise the release or seques …
Multiple intra-cellular signalling pathways rely on calcium and 3'-5' cyclic adenosine monophosphate (cAMP) to act as secondary messe …
RAFTK/Pyk2-mediated cellular signalling.
Avraham H, Park SY, Schinkmann K, Avraham S. Avraham H, et al. Cell Signal. 2000 Mar;12(3):123-33. doi: 10.1016/s0898-6568(99)00076-5. Cell Signal. 2000. PMID: 10704819 Review.
Intracellular signal transduction following extracellular ligation by a wide variety of surface molecules involves the activation and tyrosine phosphorylation of protein tyrosine kinases (PTKs). ...This review describes the role of RAFTK/Pyk2 in various signallin …
Intracellular signal transduction following extracellular ligation by a wide variety of surface molecules involves the activat …
GPCR signaling via cAMP nanodomains.
Yadav R, Zaccolo M. Yadav R, et al. Biochem J. 2025 May 13;482(10):519-33. doi: 10.1042/BCJ20253088. Biochem J. 2025. PMID: 40364615 Free PMC article. Review.
GPCRs can initiate distinct cAMP responses based on their localization within the cell, with evidence showing that both receptors resident at the plasma membrane and intracellular receptors-including endosomal, Golgi, and nuclear GPCRs-elicit unique cAMP signaling p …
GPCRs can initiate distinct cAMP responses based on their localization within the cell, with evidence showing that both receptors res …
Signal integration in budding yeast.
Waltermann C, Klipp E. Waltermann C, et al. Biochem Soc Trans. 2010 Oct;38(5):1257-64. doi: 10.1042/BST0381257. Biochem Soc Trans. 2010. PMID: 20863295 Review.
In the present article, we provide an overview of the main signalling system and discuss the mechanisms by which yeast integrates and separates signals from these sources. We apply our classification scheme to a simple semi-quantitative model of the HOG (high-osmola …
In the present article, we provide an overview of the main signalling system and discuss the mechanisms by which yeast integrates and …
Characterisation of a nucleo-adhesome.
Byron A, Griffith BGC, Herrero A, Loftus AEP, Koeleman ES, Kogerman L, Dawson JC, McGivern N, Culley J, Grimes GR, Serrels B, von Kriegsheim A, Brunton VG, Frame MC. Byron A, et al. Nat Commun. 2022 Jun 1;13(1):3053. doi: 10.1038/s41467-022-30556-5. Nat Commun. 2022. PMID: 35650196 Free PMC article.
In addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesion receptors. In experimentally defined adhesomes, we noticed that there is clear enrichment of proteins that localise to the nucleus …
In addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesi …
Mobile signals in systemic acquired resistance.
Kachroo A, Kachroo P. Kachroo A, et al. Curr Opin Plant Biol. 2020 Dec;58:41-47. doi: 10.1016/j.pbi.2020.10.004. Epub 2020 Nov 14. Curr Opin Plant Biol. 2020. PMID: 33202317 Review.
SAR involves the rapid generation of mobile signal(s) in response to localized microbial infection, which transport to the distal tissue and 'prime' them against future infections by related and unrelated pathogens. ...This review reflects on the potential ca …
SAR involves the rapid generation of mobile signal(s) in response to localized microbial infection, which transport to …
229,715 results
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