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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2004 1
2007 2
2009 1
2010 1
2011 3
2013 1
2014 2
2015 3
2016 4
2017 4
2018 9
2019 14
2020 25
2021 26
2022 42
2023 25
2024 41
2025 42
2026 25

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241 results

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Page 1
Childhood Loneliness and Cognitive Decline and Dementia Risk in Middle-Aged and Older Adults.
Wang J, Jiao D, Zhao X, Tian Y, Li H, Li X, Sheng C, Tao L, Chen H, Wu Z, Guo X. Wang J, et al. JAMA Netw Open. 2025 Sep 2;8(9):e2531493. doi: 10.1001/jamanetworkopen.2025.31493. JAMA Netw Open. 2025. PMID: 40938598 Free PMC article.
IMPORTANCE: Adult loneliness has been linked to cognitive decline and dementia risk, but the long-term implications of childhood loneliness remain underexplored. OBJECTIVES: To investigate whether childhood loneliness is associated with …
IMPORTANCE: Adult loneliness has been linked to cognitive decline and dementia risk, but the long-term implicati …
The impact of loneliness and social isolation on the development of cognitive decline and Alzheimer's Disease.
Ren Y, Savadlou A, Park S, Siska P, Epp JR, Sargin D. Ren Y, et al. Front Neuroendocrinol. 2023 Apr;69:101061. doi: 10.1016/j.yfrne.2023.101061. Epub 2023 Feb 8. Front Neuroendocrinol. 2023. PMID: 36758770 Free article. Review.
This makes the detection of the early intervention strategies to reduce future disease risk extremely important. Isolation and loneliness have been identified among the major risk factors for AD. The increasing prevalence of both loneliness and AD emphasizes the urg …
This makes the detection of the early intervention strategies to reduce future disease risk extremely important. Isolation and loneliness …
Associations of Social Isolation and Loneliness With Later Dementia.
Shen C, Rolls ET, Cheng W, Kang J, Dong G, Xie C, Zhao XM, Sahakian BJ, Feng J. Shen C, et al. Neurology. 2022 Jul 11;99(2):e164-e175. doi: 10.1212/WNL.0000000000200583. Neurology. 2022. PMID: 35676089
BACKGROUND AND OBJECTIVES: To investigate the independent associations of social isolation and loneliness with incident dementia and to explore the potential neurobiological mechanisms. ...However, the fully adjusted hazard ratio for dementia related to lo …
BACKGROUND AND OBJECTIVES: To investigate the independent associations of social isolation and loneliness with incident dementia …
Prolonged loneliness and risk of incident cognitive decline and dementia: A two-cohort study.
Ren Z, Luo Y, Liu Y, Gao J, Liu J, Zheng X. Ren Z, et al. J Affect Disord. 2025 Jun 1;378:254-262. doi: 10.1016/j.jad.2025.03.001. Epub 2025 Mar 5. J Affect Disord. 2025. PMID: 40044082
BACKGROUND: Loneliness is prevalent currently and could result in increased dementia risks, whereas the associations of prolonged loneliness and its changes with cognitive decline and dementia remain less investigated. ...CONCLUSIONS: Pro …
BACKGROUND: Loneliness is prevalent currently and could result in increased dementia risks, whereas the associations of prolon …
Sensation and Psychiatry: Linking Age-Related Hearing Loss to Late-Life Depression and Cognitive Decline.
Rutherford BR, Brewster K, Golub JS, Kim AH, Roose SP. Rutherford BR, et al. Am J Psychiatry. 2018 Mar 1;175(3):215-224. doi: 10.1176/appi.ajp.2017.17040423. Epub 2017 Dec 5. Am J Psychiatry. 2018. PMID: 29202654 Free PMC article. Review.
Behavioral mechanisms may explain these associations, such as the withdrawal of older adults from situations in which they may have difficulty hearing and communicating, which may contribute to the development of social isolation, loneliness, and consequent cognitive …
Behavioral mechanisms may explain these associations, such as the withdrawal of older adults from situations in which they may have difficul …
Loneliness and Cognitive Function in Older Adults Without Dementia: A Systematic Review and Meta-Analysis.
Harrington KD, Vasan S, Kang JE, Sliwinski MJ, Lim MH. Harrington KD, et al. J Alzheimers Dis. 2023;91(4):1243-1259. doi: 10.3233/JAD-220832. J Alzheimers Dis. 2023. PMID: 36617781 Free PMC article.
BACKGROUND: Loneliness has been highlighted as a risk factor for dementia. However, the nature of the relationship between loneliness and cognitive function prior to onset of dementia is unclear. OBJECTIVE: The aim of this systematic review and …
BACKGROUND: Loneliness has been highlighted as a risk factor for dementia. However, the nature of the relationship between …
Loneliness during the COVID-19 pandemic: A potential risk factor for post-pandemic cognitive decline in older adults without dementia.
Harb A, Souza-Talarico JN, Willey G, da Silva FC, de Jesus MCF, Deberg J. Harb A, et al. Dement Neuropsychol. 2025 Jun 2;19:e20240256. doi: 10.1590/1980-5764-DN-2024-0256. eCollection 2025. Dement Neuropsychol. 2025. PMID: 40469238 Free PMC article. Review.
OBJECTIVE: The aim of this study was to examine the association between loneliness during the COVID-19 pandemic and cognitive decline in cognitively unimpaired older adults by synthesizing evidence from primary studies. ...A total of six studies found signifi …
OBJECTIVE: The aim of this study was to examine the association between loneliness during the COVID-19 pandemic and cognitive …
Loneliness, Not Social Support, Is Associated with Cognitive Decline and Dementia Across Two Longitudinal Population-Based Cohorts.
Freak-Poli R, Wagemaker N, Wang R, Lysen TS, Ikram MA, Vernooij MW, Dintica CS, Vernooij-Dassen M, Melis RJF, Laukka EJ, Fratiglioni L, Xu W, Tiemeier H. Freak-Poli R, et al. J Alzheimers Dis. 2022;85(1):295-308. doi: 10.3233/JAD-210330. J Alzheimers Dis. 2022. PMID: 34842183 Free PMC article.
OBJECTIVE: To investigate whether loneliness and social support are independently associated with cognitive decline and risk of dementia, and whether depressive symptoms confound the association. ...Neither perceived or structural social support was as …
OBJECTIVE: To investigate whether loneliness and social support are independently associated with cognitive decline and …
Subjective Cognitive Decline in a Registry Sample: Relation to Psychiatric History, Loneliness, and Personality.
Reynolds GO, Manning L, Kirn D, Klein H, Hampton O, Burke O Jr, Buckley R, Rentz D, Sperling R, Marshall GA, Amariglio RE. Reynolds GO, et al. J Prev Alzheimers Dis. 2022;9(3):435-440. doi: 10.14283/jpad.2022.31. J Prev Alzheimers Dis. 2022. PMID: 35841244 Free PMC article.
Electronic questionnaires included questions on demographic variables, subjective cognitive decline, quality of life, loneliness, and personality. RESULTS: There was a high prevalence of risk factors for dementia in the registry sample (68% with family …
Electronic questionnaires included questions on demographic variables, subjective cognitive decline, quality of life, lonel …
Contributions of loneliness to cognitive impairment and dementia in older adults are independent of other risk factors and Alzheimer's pathology: a narrative review.
Oken BS, Kaplan J, Klee D, Gallegos AM. Oken BS, et al. Front Hum Neurosci. 2024 May 30;18:1380002. doi: 10.3389/fnhum.2024.1380002. eCollection 2024. Front Hum Neurosci. 2024. PMID: 38873650 Free PMC article. Review.
Loneliness significantly contributes to cognitive impairment and dementia in older adults. ...Loneliness needs to be assessed in all studies of cognitive decline in elders, since it significantly contributes to the variance of cognitiv …
Loneliness significantly contributes to cognitive impairment and dementia in older adults. ...Loneliness needs t …
241 results