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Year Number of Results
2005 4
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2009 1
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55 results

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Page 1
Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease.
Lange P, Celli B, Agustí A, Boje Jensen G, Divo M, Faner R, Guerra S, Marott JL, Martinez FD, Martinez-Camblor P, Meek P, Owen CA, Petersen H, Pinto-Plata V, Schnohr P, Sood A, Soriano JB, Tesfaigzi Y, Vestbo J. Lange P, et al. N Engl J Med. 2015 Jul 9;373(2):111-22. doi: 10.1056/NEJMoa1411532. N Engl J Med. 2015. PMID: 26154786 Free article.
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is thought to result from an accelerated decline in forced expiratory volume in 1 second (FEV1) over time. Yet it is possible that a normal decline in FEV1 could also lead to COPD i …
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is thought to result from an accelerated decline …
Genetic Associations and Architecture of Asthma-COPD Overlap.
John C, Guyatt AL, Shrine N, Packer R, Olafsdottir TA, Liu J, Hayden LP, Chu SH, Koskela JT, Luan J, Li X, Terzikhan N, Xu H, Bartz TM, Petersen H, Leng S, Belinsky SA, Cepelis A, Hernández Cordero AI, Obeidat M, Thorleifsson G, Meyers DA, Bleecker ER, Sakoda LC, Iribarren C, Tesfaigzi Y, Gharib SA, Dupuis J, Brusselle G, Lahousse L, Ortega VE, Jonsdottir I, Sin DD, Bossé Y, van den Berge M, Nickle D, Quint JK, Sayers I, Hall IP, Langenberg C, Ripatti S, Laitinen T, Wu AC, Lasky-Su J, Bakke P, Gulsvik A, Hersh CP, Hayward C, Langhammer A, Brumpton B, Stefansson K, Cho MH, Wain LV, Tobin MD. John C, et al. Chest. 2022 May;161(5):1155-1166. doi: 10.1016/j.chest.2021.12.674. Epub 2022 Jan 31. Chest. 2022. PMID: 35104449 Free PMC article.

RESEARCH QUESTION: What is the genetic architecture of asthma-COPD overlap, and do the determinants of risk for asthma-COPD overlap differ from those for COPD or asthma? ...We followed up promising signals (P < 5 10(-6)) that remained associated in analy

…
RESEARCH QUESTION: What is the genetic architecture of asthma-COPD overlap, and do the determinants of risk for asthma-COPD ov …
BIK polymorphism and proteasome regulation unveil host risk factor for severe influenza.
Soni S, Yildiz S, Allen EK, Petersen H, Peeples M, El Zahed S, Rosas L, Anang V, Antonescu L, Nho RS, Mora AL, Horowitz JC, Rojas M, Medina RA, Thomas PG, García-Sastre A, Tesfaigzi Y, Mebratu YA. Soni S, et al. Proc Natl Acad Sci U S A. 2025 Jul 15;122(28):e2424367122. doi: 10.1073/pnas.2424367122. Epub 2025 Jul 8. Proc Natl Acad Sci U S A. 2025. PMID: 40627391 Free PMC article.
Influenza A viruses (IAVs) pose a significant public health threat, with host factors playing a crucial role in disease severity. We investigated the role of Bcl-2-interacting killer (BIK) in IAV infection using cellular and mouse models, and influenza-infected human co …
Influenza A viruses (IAVs) pose a significant public health threat, with host factors playing a crucial role in disease severity. We …
Chronic obstructive pulmonary disease mortality, a competing risk analysis.
Abukhalaf J, Davidson R, Villalobos N, Meek P, Petersen H, Sood A, Tesfaigzi Y, Vazquez Guillamet R. Abukhalaf J, et al. Clin Respir J. 2018 Nov;12(11):2598-2605. doi: 10.1111/crj.12963. Epub 2018 Oct 25. Clin Respir J. 2018. PMID: 30257066
BACKGROUND: Current risk factors for Chronic Obstructive Pulmonary Disease mortality focus only on overall and respiratory death. We investigated whether risk factors for each specific cause of mortality are different depending on the outcome under con …
BACKGROUND: Current risk factors for Chronic Obstructive Pulmonary Disease mortality focus only on overall and r …
From pre-COPD to COPD: a Simple, Low cost and easy to IMplement (SLIM) risk calculator.
Divo MJ, Liu C, Polverino F, Castaldi PJ, Celli BR, Tesfaigzi Y. Divo MJ, et al. Eur Respir J. 2023 Sep 28;62(3):2300806. doi: 10.1183/13993003.00806-2023. Print 2023 Sep. Eur Respir J. 2023. PMID: 37678951 Free PMC article.
BACKGROUND: The lifetime risk of developing clinical COPD among smokers ranges from 13% to 22%. Identifying at-risk individuals who will develop overt disease in a reasonable timeframe may allow for early intervention. We hypothesised that readily available clinical …
BACKGROUND: The lifetime risk of developing clinical COPD among smokers ranges from 13% to 22%. Identifying at-risk individuals who w …
Identifying Metabolomic Biomarkers of Lung Function Decline in People with HIV.
Lovelace TC, Gelhaus SL, Methé B, Mullett SJ, Zhang B, Li K, Chan SY, Murray C, Gentry H, Qin S, Rinaldo CR, Benos PV, Morris A. Lovelace TC, et al. J Acquir Immune Defic Syndr. 2025 Apr 29. doi: 10.1097/QAI.0000000000003689. Online ahead of print. J Acquir Immune Defic Syndr. 2025. PMID: 40298290
BACKGROUND: Pulmonary complications in people living with HIV (PWH) have shifted away from infectious disease and towards chronic disease. HIV is an independent risk factor for chronic obstructive pulmonary disease (COPD …
BACKGROUND: Pulmonary complications in people living with HIV (PWH) have shifted away from infectious disease and towards c …
Epigenetic Repression of CCDC37 and MAP1B Links Chronic Obstructive Pulmonary Disease to Lung Cancer.
Tessema M, Yingling CM, Picchi MA, Wu G, Liu Y, Weissfeld JL, Siegfried JM, Tesfaigzi Y, Belinsky SA. Tessema M, et al. J Thorac Oncol. 2015 Aug;10(8):1181-8. doi: 10.1097/JTO.0000000000000592. J Thorac Oncol. 2015. PMID: 26200272 Free PMC article.
INTRODUCTION: Lung cancer and chronic obstructive pulmonary disease (COPD) share environmental risk factors. COPD also increases the risk of lung cancer; however, the molecular mechanisms are unclear. ...CCDC37 methylation was more preval …
INTRODUCTION: Lung cancer and chronic obstructive pulmonary disease (COPD) share environmental risk facto …
Circulating biomarkers of airflow limitation across the life span.
Zhai J, Voraphani N, Imboden M, Keidel D, Liu C, Stern DA, Venker C, Petersen H, Bosco A, Sherrill DL, Morgan WJ, Tesfaigzi Y, Probst-Hensch NM, Martinez FD, Halonen M, Guerra S. Zhai J, et al. J Allergy Clin Immunol. 2024 Jun;153(6):1692-1703. doi: 10.1016/j.jaci.2023.12.026. Epub 2024 Jan 20. J Allergy Clin Immunol. 2024. PMID: 38253260 Free PMC article.
BACKGROUND: Airflow limitation is a hallmark of chronic obstructive pulmonary disease, which can develop through different lung function trajectories across the life span. ...CONCLUSIONS: A signature of 5 circulating biomarkers of airflow limitation wa …
BACKGROUND: Airflow limitation is a hallmark of chronic obstructive pulmonary disease, which can develop through …
Development and validation of a mortality risk prediction model for chronic obstructive pulmonary disease: a cross-sectional study using probabilistic graphical modelling.
Lovelace TC, Ryu MH, Jia M, Castaldi P, Sciurba FC, Hersh CP, Benos PV. Lovelace TC, et al. EClinicalMedicine. 2024 Aug 22;75:102786. doi: 10.1016/j.eclinm.2024.102786. eCollection 2024 Sep. EClinicalMedicine. 2024. PMID: 39263674 Free PMC article.
BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of mortality. Predicting mortality risk in patients with COPD can be important for disease management strategies. ...We applied graphical models on multi-m …
BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of mortality. Predicting mort …
A retrospective study to assess clinical characteristics and time to initiation of open-triple therapy among patients with chronic obstructive pulmonary disease, newly established on long-acting mono- or combination therapy.
Mapel D, Laliberté F, Roberts MH, Sama SR, Sundaresan D, Pilon D, Lefebvre P, Duh MS, Patel J. Mapel D, et al. Int J Chron Obstruct Pulmon Dis. 2017 Jun 21;12:1825-1836. doi: 10.2147/COPD.S129007. eCollection 2017. Int J Chron Obstruct Pulmon Dis. 2017. PMID: 28684905 Free PMC article.
INTRODUCTION: An incremental approach using open-triple therapy may improve outcomes in patients with chronic obstructive pulmonary disease (COPD). However, there is little sufficient, real-world evidence available identifying time to open-tripl …
INTRODUCTION: An incremental approach using open-triple therapy may improve outcomes in patients with chronic obstructive p …
55 results