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Amitriptyline at Low-Dose and Titrated for Irritable Bowel Syndrome as Second-Line Treatment in primary care (ATLANTIS): a randomised, double-blind, placebo-controlled, phase 3 trial.
Ford AC, Wright-Hughes A, Alderson SL, Ow PL, Ridd MJ, Foy R, Bianco G, Bishop FL, Chaddock M, Cook H, Cooper D, Fernandez C, Guthrie EA, Hartley S, Herbert A, Howdon D, Muir DP, Nath T, Newman S, Smith T, Taylor CA, Teasdale EJ, Thornton R, Farrin AJ, Everitt HA; ATLANTIS trialists. Ford AC, et al. Lancet. 2023 Nov 11;402(10414):1773-1785. doi: 10.1016/S0140-6736(23)01523-4. Epub 2023 Oct 16. Lancet. 2023. PMID: 37858323 Free article. Clinical Trial.
BACKGROUND: Most patients with irritable bowel syndrome (IBS) are managed in primary care. When first-line therapies for IBS are ineffective, the UK National Institute for Health and Care Excellence guideline suggests considering low- dose tricyclic …
BACKGROUND: Most patients with irritable bowel syndrome (IBS) are managed in primary care. When first-line therapies for IBS a …
Low-dose titrated amitriptyline as second-line treatment for adults with irritable bowel syndrome in primary care: the ATLANTIS RCT.
Wright-Hughes A, Ford AC, Alderson SL, Ow PL, Ridd MJ, Foy R, Bishop FL, Chaddock M, Cook H, Cooper D, Fernandez C, Guthrie EA, Hartley S, Herbert A, Howdon D, Muir DP, Newman S, Taylor CA, Teasdale EJ, Thornton R, Everitt HA, Farrin AJ. Wright-Hughes A, et al. Health Technol Assess. 2024 Oct;28(66):1-161. doi: 10.3310/BFCR7986. Health Technol Assess. 2024. PMID: 39397570 Free PMC article. Clinical Trial.
When first-line therapies are ineffective, National Institute for Health and Care Excellence guidelines suggest considering low-dose tricyclic antidepressants as second-line treatment, but their effectiveness in primary care is unknown and they are infrequent …
When first-line therapies are ineffective, National Institute for Health and Care Excellence guidelines suggest considering low-do …
Predictors of response to low-dose amitriptyline for irritable bowel syndrome and efficacy and tolerability according to subtype: post hoc analyses from the ATLANTIS trial.
Wright-Hughes A, Ow PL, Alderson SL, Ridd MJ, Foy R, Bishop FL, Chaddock M, Fernandez C, Guthrie EA, Muir DP, Taylor CA, Farrin AJ, Everitt HA, Ford AC. Wright-Hughes A, et al. Gut. 2025 Apr 7;74(5):728-739. doi: 10.1136/gutjnl-2024-334490. Gut. 2025. PMID: 39863398 Free PMC article.
BACKGROUND: Low-dose amitriptyline, a tricyclic antidepressant (TCA), was superior to placebo for irritable bowel syndrome (IBS) in the AmitripTyline at Low-dose ANd Titrated for Irritable bowel syndrome as Second-line treatment (A …
BACKGROUND: Low-dose amitriptyline, a tricyclic antidepressant (TCA), was superior to placebo for irritable bowe …
Efficacy of a single low dose of esketamine for patients with irritable bowel syndrome: study protocol for a randomised controlled trial.
Sun Z, Jiang L, Xing Y, Luo F. Sun Z, et al. BMJ Open. 2025 Jun 23;15(6):e099793. doi: 10.1136/bmjopen-2025-099793. BMJ Open. 2025. PMID: 40550724 Free PMC article.
At present, the conventional treatment of IBS remains somewhat unsatisfactory. Studies have shown that the antidepressant effects of esketamine are rapid and significant, whether a single low dose of esketamine is effective in IBS deserves furth …
At present, the conventional treatment of IBS remains somewhat unsatisfactory. Studies have shown that the antidepressant effe …
Irritable Bowel Syndrome.
Wald A. Wald A. Curr Treat Options Gastroenterol. 1999 Feb;2(1):13-19. doi: 10.1007/s11938-999-0013-6. Curr Treat Options Gastroenterol. 1999. PMID: 11096567
For chronic visceral pain syndromes, I recommend small doses of tricyclic antidepressants. These agents are especially effective in diarrhea-predominant patients with disturbed sleep patterns but may be unacceptable to patients with constipation. ...I have found tha …
For chronic visceral pain syndromes, I recommend small doses of tricyclic antidepressants. These agents are especially effecti …
Low-dose amitriptyline for irritable bowel syndrome: a qualitative study of patients' and GPs' views and experiences.
Teasdale EJ, Everitt HA, Alderson SL, Ford AC, Hanney J, Chaddock M, Williamson E, Cook H, Farrin AJ, Fernandez C, Guthrie EA, Hartley S, Herbert A, Howdon D, Muir D, Newman S, Ow PL, Ridd MJ, Taylor CM, Thornton R, Wright-Hughes A, Bishop FL. Teasdale EJ, et al. Br J Gen Pract. 2025 May 29;75(755):e431-e439. doi: 10.3399/BJGP.2024.0303. Print 2025 Jun. Br J Gen Pract. 2025. PMID: 39191441 Free PMC article.
Guidelines suggest low-dose amitriptyline for IBS as second-line treatment, but this is rarely prescribed in primary care. ...CONCLUSION: Patients and GPs felt that the potential benefits of trying low-dose amitriptyline for IBS outweighe …
Guidelines suggest low-dose amitriptyline for IBS as second-line treatment, but this is rarely prescribed in primary ca …
[Chronic, non-infectious diarrhea: diagnostics and therapy].
Ulbricht K, Layer P, Andresen V. Ulbricht K, et al. Dtsch Med Wochenschr. 2016 Sep;141(19):1395-402. doi: 10.1055/s-0042-108700. Epub 2016 Sep 19. Dtsch Med Wochenschr. 2016. PMID: 27642742 Review. German.
Additional approaches in intractable irritable bowel syndrome with diarrhea (IBS-D) include 5-HT3 receptor antagonists, the antibiotic Rifaximin as well as low-dose tricyclic antidepressants. Specific diets such as the low-FODMAP diet can also r …
Additional approaches in intractable irritable bowel syndrome with diarrhea (IBS-D) include 5-HT3 receptor antagonists, the antibioti …
Amitriptyline at low-dose and titrated for irritable bowel syndrome as second-line treatment (The ATLANTIS trial): protocol for a randomised double-blind placebo-controlled trial in primary care.
Alderson SL, Wright-Hughes A, Ford AC, Farrin A, Hartley S, Fernandez C, Taylor C, Ow PL, Teasdale E, Howdon D, Guthrie E, Foy R, Ridd MJ, Bishop FL, Muir D, Chaddock M, Herbert A, Cooper D, Gibbins R, Newman S, Cook H, Longo R, Everitt H. Alderson SL, et al. Trials. 2022 Jul 8;23(1):552. doi: 10.1186/s13063-022-06492-6. Trials. 2022. PMID: 35804433 Free PMC article.
METHODS: ATLANTIS is a randomised, multi-centre, parallel-group, two-arm, double-blind, placebo-controlled trial of low-dose amitriptyline as a second-line treatment for IBS in primary care. Participants will be invited by letter, or recruited opportunistical …
METHODS: ATLANTIS is a randomised, multi-centre, parallel-group, two-arm, double-blind, placebo-controlled trial of low-dose a …
Efficacy of tricyclic antidepressants in irritable bowel syndrome: a meta-analysis.
Rahimi R, Nikfar S, Rezaie A, Abdollahi M. Rahimi R, et al. World J Gastroenterol. 2009 Apr 7;15(13):1548-53. doi: 10.3748/wjg.15.1548. World J Gastroenterol. 2009. PMID: 19340896 Free PMC article.
We aimed to evaluate the efficacy of tricyclic antidepressants (TCAs) as a therapeutic option for irritable bowel syndrome (IBS) through meta-analysis of randomized controlled trials. ...Effect size of TCAs versus placebo for mean change in abdominal pain score amon …
We aimed to evaluate the efficacy of tricyclic antidepressants (TCAs) as a therapeutic option for irritable bowel syndrome (IBS …
The association of functional gastrointestinal disorders and fibromyalgia.
Chang L. Chang L. Eur J Surg Suppl. 1998;(583):32-6. doi: 10.1080/11024159850191210. Eur J Surg Suppl. 1998. PMID: 10027670 Review.
Up to 50% of patients with a diagnosis of FM syndrome complain of symptoms characteristic of functional dyspepsia and 70% have symptoms of IBS. These two conditions have common clinical characteristics: (1) the majority of patients associate stressful life events with the …
Up to 50% of patients with a diagnosis of FM syndrome complain of symptoms characteristic of functional dyspepsia and 70% have symptoms of …
15 results