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Page 1
Systemic estradiol levels with low-dose vaginal estrogens.
Santen RJ, Mirkin S, Bernick B, Constantine GD. Santen RJ, et al. Menopause. 2020 Mar;27(3):361-370. doi: 10.1097/GME.0000000000001463. Menopause. 2020. PMID: 31794498 Free PMC article.
Estradiol absorption was dose-dependent, and may be influenced by dose, formulation, and positioning in the vagina. Very low systemic estradiol absorption with low/ultralow-dose vaginal estrogens …
Estradiol absorption was dose-dependent, and may be influenced by dose, formulation, and positioning in the v …
Management of postmenopausal vulvovaginal atrophy: recommendations of the International Society for the Study of Vulvovaginal Disease.
Pérez-López FR, Phillips N, Vieira-Baptista P, Cohen-Sacher B, Fialho SCAV, Stockdale CK. Pérez-López FR, et al. Gynecol Endocrinol. 2021 Aug;37(8):746-752. doi: 10.1080/09513590.2021.1943346. Epub 2021 Jun 25. Gynecol Endocrinol. 2021. PMID: 34169794 Review.
Beneficial options include lubricants, moisturizers, vaginal estrogens (estradiol, estriol, promestriene, conjugated estrogens), androgens, prasterone, and laser application. ...In breast cancer survivors, moisturizers and lubricants are first line therapy. However, …
Beneficial options include lubricants, moisturizers, vaginal estrogens (estradiol, estriol, promestriene, conjugated estrogens …
TX-004HR vaginal estradiol has negligible to very low systemic absorption of estradiol.
Archer DF, Constantine GD, Simon JA, Kushner H, Mayer P, Bernick B, Graham S, Mirkin S; REJOICE Study Group. Archer DF, et al. Menopause. 2017 May;24(5):510-516. doi: 10.1097/GME.0000000000000790. Menopause. 2017. PMID: 28002201 Free PMC article. Clinical Trial.
OBJECTIVE: To evaluate the pharmacokinetics of TX-004HR vaginal estradiol softgel capsules when used for treating moderate-to-severe dyspareunia in postmenopausal women with vulvar and vaginal atrophy. ...No drug accumulation was observed. CONCLUSIONS: Vag …
OBJECTIVE: To evaluate the pharmacokinetics of TX-004HR vaginal estradiol softgel capsules when used for treating moderate-to- …
A vaginal estradiol softgel capsule, TX-004HR, has negligible to very low systemic absorption of estradiol: Efficacy and pharmacokinetic data review.
Simon JA, Archer DF, Constantine GD, Pickar JH, Amadio JM, Bernick B, Graham S, Mirkin S. Simon JA, et al. Maturitas. 2017 May;99:51-58. doi: 10.1016/j.maturitas.2017.02.008. Epub 2017 Feb 16. Maturitas. 2017. PMID: 28364869 Free article. Review.
This paper reviews the efficacy, safety, and systemic absorption of estradiol with TX-004HR, an investigational, low-dose 17beta-estradiol vaginal softgel capsule, designed to treat vulvar and vaginal atrophy (VVA) in postme …
This paper reviews the efficacy, safety, and systemic absorption of estradiol with TX-004HR, an investigational, low …
Vaginal administration of estradiol: effects of dose, preparation and timing on plasma estradiol levels.
Santen RJ. Santen RJ. Climacteric. 2015 Apr;18(2):121-34. doi: 10.3109/13697137.2014.947254. Epub 2014 Oct 18. Climacteric. 2015. PMID: 25327484 Review.
Each preparation was associated with acute estradiol absorption with peaks at approximately 8 h and return to baseline at 12 h. Low-dose vaginal estrogen, arbitrarily defined as the 7.5-mug vaginal ring and 10-mug tablet, increased plasma …
Each preparation was associated with acute estradiol absorption with peaks at approximately 8 h and return to baseline at 12 h …
Ultra-low-dose vaginal estrogen tablets for the treatment of postmenopausal vaginal atrophy.
Simon JA, Maamari RV. Simon JA, et al. Climacteric. 2013 Aug;16 Suppl 1:37-43. doi: 10.3109/13697137.2013.807606. Climacteric. 2013. PMID: 23848490 Review.
These symptoms can be safely and effectively managed with the use of local estrogen therapy, which reduces the risks associated with long-term systemic hormone therapy. The ultra-low-dose 10 mug estradiol vaginal tablet is the lowest approved …
These symptoms can be safely and effectively managed with the use of local estrogen therapy, which reduces the risks associated with long-te …
Vaginal administration of low-dose conjugated estrogens: systemic absorption and effects on the endometrium.
Handa VL, Bachus KE, Johnston WW, Robboy SJ, Hammond CB. Handa VL, et al. Obstet Gynecol. 1994 Aug;84(2):215-8. Obstet Gynecol. 1994. PMID: 8041532
OBJECTIVE: To test the hypothesis tha a very-low-dose regimen of vaginal estrogen would provide effective relief from atrophic vaginitis without endometrial proliferation. ...Endometrial proliferation may occur at this low dose, albeit ra …
OBJECTIVE: To test the hypothesis tha a very-low-dose regimen of vaginal estrogen would provide effective relief from a …
Different local estrogen therapies for a tailored approach to GSM.
Nappi RE, Tiranini L, Martini E, Bosoni D, Cassani C, Cucinella L. Nappi RE, et al. Climacteric. 2023 Aug;26(4):361-366. doi: 10.1080/13697137.2023.2218998. Epub 2023 Jun 15. Climacteric. 2023. PMID: 37318030 Review.
Over the years, several vaginal products including different formulations (tablets, rings, capsules, pessaries, creams, gels and ovules) and molecules (estradiol [E2], estriol [E3], promestriene, conjugated equine estrogens and estrone) have been used with superimpo …
Over the years, several vaginal products including different formulations (tablets, rings, capsules, pessaries, creams, gels and ovul …
Treatment of postmenopausal vaginal atrophy with 10-mug estradiol vaginal tablets.
Panay N, Maamari R. Panay N, et al. Menopause Int. 2012 Mar;18(1):15-9. doi: 10.1258/mi.2012.011120. Menopause Int. 2012. PMID: 22393176 Review.
The development of the ultra-low-dose 10- g estradiol vaginal tablets is in line with the requirements of regulatory agencies and women's health societies regarding the use of the lowest effective hormonal dose. Because of its effectiveness and …
The development of the ultra-low-dose 10- g estradiol vaginal tablets is in line with the requirements of regula …
Evaluation of endometrial progesterone receptor expression after 12 weeks of exposure to a low-dose vaginal estradiol insert.
Mirkin S, Simon JA, Liu JH, Archer DF, Castro PD, Graham S, Bernick B, Komm B. Mirkin S, et al. Menopause. 2021 May 28;28(9):998-1003. doi: 10.1097/GME.0000000000001801. Menopause. 2021. PMID: 34054104 Free PMC article. Clinical Trial.
CONCLUSIONS: No meaningful differences in endometrial PGR expression were observed with the vaginal E2 (4- and 10-mug) inserts at week 12 from baseline, supporting the hypothesis that local exposure to E2 from a low-dose, vaginal insert placed near the …
CONCLUSIONS: No meaningful differences in endometrial PGR expression were observed with the vaginal E2 (4- and 10-mug) inserts at wee …
22 results