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430 results

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Page 1
A trial of intraoperative low-tidal-volume ventilation in abdominal surgery.
Futier E, Constantin JM, Paugam-Burtz C, Pascal J, Eurin M, Neuschwander A, Marret E, Beaussier M, Gutton C, Lefrant JY, Allaouchiche B, Verzilli D, Leone M, De Jong A, Bazin JE, Pereira B, Jaber S; IMPROVE Study Group. Futier E, et al. N Engl J Med. 2013 Aug 1;369(5):428-37. doi: 10.1056/NEJMoa1301082. N Engl J Med. 2013. PMID: 23902482 Free article. Clinical Trial.
However, its role in anesthetized patients undergoing major surgery is not known. METHODS: In this multicenter, double-blind, parallel-group trial, we randomly assigned 400 adults at intermediate to high risk of pulmonary complications after major abdominal surgery …
However, its role in anesthetized patients undergoing major surgery is not known. METHODS: In this multicenter, double-blind, paralle …
Effect of Intraoperative Low Tidal Volume vs Conventional Tidal Volume on Postoperative Pulmonary Complications in Patients Undergoing Major Surgery: A Randomized Clinical Trial.
Karalapillai D, Weinberg L, Peyton P, Ellard L, Hu R, Pearce B, Tan CO, Story D, O'Donnell M, Hamilton P, Oughton C, Galtieri J, Wilson A, Serpa Neto A, Eastwood G, Bellomo R, Jones DA. Karalapillai D, et al. JAMA. 2020 Sep 1;324(9):848-858. doi: 10.1001/jama.2020.12866. JAMA. 2020. PMID: 32870298 Free PMC article. Clinical Trial.
IMPORTANCE: In patients who undergo mechanical ventilation during surgery, the ideal tidal volume is unclear. OBJECTIVE: To determine whether low-tidal-volume ventilation compared with conventional ventilation during major …
IMPORTANCE: In patients who undergo mechanical ventilation during surgery, the ideal tidal volume is unclear. OBJECTIVE …
Low-Tidal-Volume Ventilation and Mortality in Patients With Acute Brain Injury: A Secondary Analysis of an International Observational Study.
Daza JF, Hamad DM, Urner M, Liu K, Wahlster S, Robba C, Stevens RD, McCredie VA, Cinotti R, Taran S; ENIO Study Group; PROtective VENTilation Network; European Society of Intensive Care Medicine; Colegio Mexicano de Medicina Critica; AtlanRéa Group; Société Française d’Anesthésie-Réanimation–SFAR Research Network. Daza JF, et al. Chest. 2025 Nov;168(5):1141-1151. doi: 10.1016/j.chest.2025.06.042. Epub 2025 Jul 8. Chest. 2025. PMID: 40639639 Free PMC article.
BACKGROUND: Low-tidal-volume ventilation (LTVV) improves outcomes in critically ill patients, but its impact in patients with acute brain injuries (ABIs) is less certain. ...INTERPRETATION: In this predominantly non-ARDS cohort of patients with ABI, LT …
BACKGROUND: Low-tidal-volume ventilation (LTVV) improves outcomes in critically ill patients, but its impact in …
Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial.
McNamee JJ, Gillies MA, Barrett NA, Perkins GD, Tunnicliffe W, Young D, Bentley A, Harrison DA, Brodie D, Boyle AJ, Millar JE, Szakmany T, Bannard-Smith J, Tully RP, Agus A, McDowell C, Jackson C, McAuley DF; REST Investigators. McNamee JJ, et al. JAMA. 2021 Sep 21;326(11):1013-1023. doi: 10.1001/jama.2021.13374. JAMA. 2021. PMID: 34463700 Free PMC article. Clinical Trial.
IMPORTANCE: In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared with conventional low tidal volume ventilation, may improve outcomes. ...CONCLUSIONS AND RELE …
IMPORTANCE: In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal …
Low tidal volume ventilation for patients undergoing laparoscopic surgery: a secondary analysis of a randomised clinical trial.
Karalapillai D, Weinberg L, Neto AS, Peyton PJ, Ellard L, Hu R, Pearce B, Tan CO, Story D, O'Donnell M, Hamilton P, Oughton C, Galtieri J, Wilson A, Liskaser G, Balasubramaniam A, Eastwood G, Bellomo R, Jones DA. Karalapillai D, et al. BMC Anesthesiol. 2023 Mar 7;23(1):71. doi: 10.1186/s12871-023-01998-1. BMC Anesthesiol. 2023. PMID: 36882701 Free PMC article. Clinical Trial.
BACKGROUND: We recently reported the results for a large randomized controlled trial of low tidal volume ventilation (LTVV) versus conventional tidal volume (CTVV) during major surgery when positive end expiratory pressure (PEEP) was equal betwe …
BACKGROUND: We recently reported the results for a large randomized controlled trial of low tidal volume ventilation …
Low-tidal-volume ventilation.
Chiche L, Forel JM, Papazian L. Chiche L, et al. N Engl J Med. 2007 Dec 13;357(24):2518-9; author reply 2519-20. doi: 10.1056/NEJMc072900. N Engl J Med. 2007. PMID: 18077819 No abstract available.
Commentary: Low tidal volume ventilation: How low can you go?
Karush J, Liptay M. Karush J, et al. J Thorac Cardiovasc Surg. 2022 Apr;163(4):1586-1587. doi: 10.1016/j.jtcvs.2020.12.124. Epub 2021 Jan 10. J Thorac Cardiovasc Surg. 2022. PMID: 33563425 Free article. No abstract available.
Low tidal volume ventilation during anaesthesia for major surgery: protocol and statistical analysis plan.
Karalapillai D, Weinberg L, Peyton P, Ellard L, Hu R, Pearce B, Tan C, Story D, ODonnell M, Hamilton P, Oughton C, Galtieri J, Wilson A, Neto AS, Eastwood G, Bellomo R, Jones DA. Karalapillai D, et al. Crit Care Resusc. 2019 Dec;21(4):243-50. Crit Care Resusc. 2019. PMID: 31778630
BACKGROUND: Mechanical ventilation is mandatory in patients undergoing general anaesthesia for major surgery. ...RESULTS AND CONCLUSIONS: This is the first well powered study comparing the effect of low tidal volume ventilation …
BACKGROUND: Mechanical ventilation is mandatory in patients undergoing general anaesthesia for major surgery. .. …
Intraoperative low tidal volume ventilation and the risk of ICD-10 coded delirium and the use for antipsychotic medications.
Karalapillai D, Weinberg L, Neto AS, Peyton PJ, Ellard L, Hu R, Pearce B, Tan C, Story D, O'Donnell M, Hamilton P, Oughton C, Galtieri J, Appu S, Wilson A, Eastwood G, Bellomo R, Jones DA. Karalapillai D, et al. BMC Anesthesiol. 2022 May 16;22(1):149. doi: 10.1186/s12871-022-01689-3. BMC Anesthesiol. 2022. PMID: 35578170 Free PMC article. Clinical Trial.
BACKGROUND: Low tidal volume (V(T)) ventilation and its associated increase in arterial carbon dioxide (PaCO(2)) may affect postoperative neurologic function. ...There was no interaction between allocation group and type of surgery. CONCLUSION: …
BACKGROUND: Low tidal volume (V(T)) ventilation and its associated increase in arterial carbon dioxide (PaCO(2)) …
Intraoperative low-tidal-volume ventilation.
Mynbaev OA, Biro P, Stark M. Mynbaev OA, et al. N Engl J Med. 2013 Nov 7;369(19):1862. doi: 10.1056/NEJMc1311316. N Engl J Med. 2013. PMID: 24195562 Free article. No abstract available.
430 results