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[Acute poisoning by new psychotropic drugs].
Harry P. Harry P. Rev Prat. 1997 Apr 1;47(7):731-5. Rev Prat. 1997. PMID: 9183949 Review. French.
Poisoning with new selective serotonin reuptake inhibitor antidepressants or monoamine-oxidase inhibitors type A (toloxatone, moclobemide) is usually not severe, but life-threatening serotonin syndromes may appear in case of drug combination with antidepressants. Loxapine …
Poisoning with new selective serotonin reuptake inhibitor antidepressants or monoamine-oxidase inhibitors type A (toloxatone, moclobemide) i …
A randomized, placebo-controlled repeat-dose thorough QT study of inhaled loxapine in healthy volunteers.
Cassella JV, Spyker DA, Yeung PP. Cassella JV, et al. Int J Clin Pharmacol Ther. 2015 Nov;53(11):963-71. Int J Clin Pharmacol Ther. 2015. PMID: 26501204 Free article. Clinical Trial.
OBJECTIVE: This randomized, double-blind, active- and placebo-controlled, crossover, thorough QT study assessed the effect of two inhaled loxapine doses on cardiac repolarization as measured by corrected QT (QTc) interval in healthy subjects (ClinicalTrials.g …
OBJECTIVE: This randomized, double-blind, active- and placebo-controlled, crossover, thorough QT study assessed the effect of two inh …
First generation antipsychotic-associated serious adverse events in women: a retrospective analysis of a pharmacovigilance database.
McCall KL, Doughty BJ, Piper BJ, Naik H, Bange S, Leppien EE. McCall KL, et al. Int J Clin Pharm. 2024 Apr;46(2):515-521. doi: 10.1007/s11096-023-01693-8. Epub 2024 Feb 5. Int J Clin Pharm. 2024. PMID: 38315306
The study cohort consisted of chlorpromazine (n = 3317), fluphenazine (n = 1124), haloperidol (n = 16,709), loxapine (n = 3151), perphenazine (n = 816), thioridazine (n = 665), thiothixene (n = 244), and trifluoperazine (n = 360). Cases of neuroleptic malignant syndrome (N …
The study cohort consisted of chlorpromazine (n = 3317), fluphenazine (n = 1124), haloperidol (n = 16,709), loxapine (n = 3151), perp …
A randomized, placebo-controlled repeat-dose thorough QT study of inhaled loxapine in healthy volunteers.
Cassella JV, Spyker DA, Yeung PP. Cassella JV, et al. Int J Clin Pharmacol Ther. 2015 Oct 7;53(11):963-71. doi: 10.5414/CP202457. Online ahead of print. Int J Clin Pharmacol Ther. 2015. PMID: 26445139 Free PMC article.
OBJECTIVE: This randomized, double-blind, active- and placebo-controlled, crossover, thorough QT study assessed the effect of two inhaled loxapine doses on cardiac repolarization as measured by corrected QT (QTc) interval in healthy subjects (ClinicalTrials.g …
OBJECTIVE: This randomized, double-blind, active- and placebo-controlled, crossover, thorough QT study assessed the effect of two inh …
Loxapine delivered as a thermally generated aerosol does not prolong QTc in a thorough QT/QTc study in healthy subjects.
Spyker DA, Voloshko P, Heyman ER, Cassella JV. Spyker DA, et al. J Clin Pharmacol. 2014 Jun;54(6):665-74. doi: 10.1002/jcph.257. Epub 2014 Jan 22. J Clin Pharmacol. 2014. PMID: 24375070 Clinical Trial.
Inhaled loxapine did not increase QT intervals, as demonstrated by the upper bound of the 1-sided 95% CIs placed on the point estimate of the placebo-subtracted change of QTcI (deltadeltaQTcI) being less than 10 milliseconds at all 11 post-dose times. ...The analyse …
Inhaled loxapine did not increase QT intervals, as demonstrated by the upper bound of the 1-sided 95% CIs placed on the point …
Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine.
Obers S, Staudacher I, Ficker E, Dennis A, Koschny R, Erdal H, Bloehs R, Kisselbach J, Karle CA, Schweizer PA, Katus HA, Thomas D. Obers S, et al. Naunyn Schmiedebergs Arch Pharmacol. 2010 May;381(5):385-400. doi: 10.1007/s00210-010-0496-7. Epub 2010 Mar 13. Naunyn Schmiedebergs Arch Pharmacol. 2010. PMID: 20229012 Free article.
The antidepressant amoxapine has been linked to cases of QT prolongation, acute heart failure, and sudden death. Inhibition of cardiac hERG (Kv11.1) potassium channels causes prolonged repolarization and is implicated in apoptosis. ...
The antidepressant amoxapine has been linked to cases of QT prolongation, acute heart failure, and sudden death. Inhibition of cardia …