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Year Number of Results
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59 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Comparative profiles of lubiprostone, linaclotide, and elobixibat for chronic constipation: a systematic literature review with meta-analysis and number needed to treat/harm.
Rao SS, Manabe N, Karasawa Y, Hasebe Y, Nozawa K, Nakajima A, Fukudo S. Rao SS, et al. BMC Gastroenterol. 2024 Jan 2;24(1):12. doi: 10.1186/s12876-023-03104-8. BMC Gastroenterol. 2024. PMID: 38166671 Free PMC article.
OBJECTIVE: To comprehensively evaluate the efficacy, safety, patient symptoms, and quality-of-life (QoL) of lubiprostone, linaclotide, and elobixibat as treatment for chronic constipation (CC). DESIGN: Systematic literature review (SLR) and meta-analysis (MA). ...However, …
OBJECTIVE: To comprehensively evaluate the efficacy, safety, patient symptoms, and quality-of-life (QoL) of lubiprostone, linaclotide …
Systematic review with meta-analysis: lubiprostone efficacy on the treatment of patients with constipation.
Passos MDCF, Takemoto MLS, Corradino GC, Guedes LS. Passos MDCF, et al. Arq Gastroenterol. 2020 Oct-Dec;57(4):498-506. doi: 10.1590/S0004-2803.202000000-83. Arq Gastroenterol. 2020. PMID: 33331483 Free article.
Qualitative synthesis showed that for CIC patients, lubiprostone is superior to placebo in terms of SBM outcomes. Meta-analysis for CIC was feasible for full responder and SBM within 24h rates, indicating superiority of lubiprostone over placebo. ...For OIC, lubi …
Qualitative synthesis showed that for CIC patients, lubiprostone is superior to placebo in terms of SBM outcomes. Meta-analysis for C …
Lubiprostone for Pediatric Functional Constipation: Randomized, Controlled, Double-Blind Study With Long-term Extension.
Benninga MA, Hussain SZ, Sood MR, Nurko S, Hyman P, Clifford RA, O'Gorman M, Losch-Beridon T, Mareya S, Lichtlen P, Di Lorenzo C. Benninga MA, et al. Clin Gastroenterol Hepatol. 2022 Mar;20(3):602-610.e5. doi: 10.1016/j.cgh.2021.04.005. Epub 2021 Apr 7. Clin Gastroenterol Hepatol. 2022. PMID: 33838349 Free article. Clinical Trial.
RESULTS: 606 patients were randomized to treatment (placebo: n = 202; lubiprostone: n = 404) in study 1. No statistically significant difference in overall SBM response rate was observed between the lubiprostone and placebo groups (18.5% vs 14.4%; P = .2245). Both t …
RESULTS: 606 patients were randomized to treatment (placebo: n = 202; lubiprostone: n = 404) in study 1. No statistically significant …
Efficacy of lubiprostone for functional constipation treatment in adolescents and children: Randomized controlled trial.
Elkaragy ES, Shamseya MM, Metwally RH, Mansour ER, Lashen SA. Elkaragy ES, et al. J Pediatr Gastroenterol Nutr. 2024 Apr;78(4):800-809. doi: 10.1002/jpn3.12135. Epub 2024 Feb 5. J Pediatr Gastroenterol Nutr. 2024. PMID: 38314885 Clinical Trial.
OBJECTIVES: Adolescent and pediatric functional constipation (FC) is a common clinical problem. Currently, data on lubiprostone for the treatment of pediatric FC are scarce. This study investigated the efficacy and safety of lubiprostone in the treatment of pediatri …
OBJECTIVES: Adolescent and pediatric functional constipation (FC) is a common clinical problem. Currently, data on lubiprostone for t …
Lubiprostone Is Effective in the Treatment of Chronic Idiopathic Constipation and Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Li F, Fu T, Tong WD, Liu BH, Li CX, Gao Y, Wu JS, Wang XF, Zhang AP. Li F, et al. Mayo Clin Proc. 2016 Apr;91(4):456-68. doi: 10.1016/j.mayocp.2016.01.015. Mayo Clin Proc. 2016. PMID: 27046523
OBJECTIVE: To evaluate the efficacy and safety of lubiprostone in the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). ...At 3 months, except for abdominal bloating (P=.03), there was no difference between lubipr …
OBJECTIVE: To evaluate the efficacy and safety of lubiprostone in the treatment of chronic idiopathic constipation (CIC) and irritabl …
Lubiprostone in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled, phase 2a trial.
Kessoku T, Imajo K, Kobayashi T, Ozaki A, Iwaki M, Honda Y, Kato T, Ogawa Y, Tomeno W, Kato S, Higurashi T, Yoneda M, Kirikoshi H, Kubota K, Taguri M, Yamanaka T, Usuda H, Wada K, Kobayashi N, Saito S, Nakajima A. Kessoku T, et al. Lancet Gastroenterol Hepatol. 2020 Nov;5(11):996-1007. doi: 10.1016/S2468-1253(20)30216-8. Epub 2020 Aug 15. Lancet Gastroenterol Hepatol. 2020. PMID: 32805205 Clinical Trial.
BACKGROUND: The laxative drug lubiprostone improves intestinal permeability in healthy volunteers. We aimed to assess efficacy and safety of lubiprostone in patients with non-alcoholic fatty liver disease (NAFLD) with constipation via attenuation of intestinal perme …
BACKGROUND: The laxative drug lubiprostone improves intestinal permeability in healthy volunteers. We aimed to assess efficacy and sa …
A meta-analysis of randomized controlled trials of the addition of lubiprostone to bowel preparation before colonoscopy.
Li P, He XQ, Dong J, Du J. Li P, et al. Medicine (Baltimore). 2020 Feb;99(8):e19208. doi: 10.1097/MD.0000000000019208. Medicine (Baltimore). 2020. PMID: 32080109 Free PMC article.
We performed a meta-analysis to determine the efficacy and safety of the addition of lubiprostone to the bowel preparation process prior to colonoscopy. METHODS: Online databases, namely, PubMed, MEDLINE and Cochrane Library, were searched for randomized controlled trials …
We performed a meta-analysis to determine the efficacy and safety of the addition of lubiprostone to the bowel preparation process pr …
Comparative Efficacy and Safety of Lubiprostone and Osmotic Laxatives in Chronic Idiopathic Constipation: A Systematic Review and Network Meta-Analysis.
Yang L, Zong Y, Meng F, Wu Y, Zhang S. Yang L, et al. J Gastroenterol Hepatol. 2025 Feb;40(2):387-397. doi: 10.1111/jgh.16844. Epub 2024 Dec 11. J Gastroenterol Hepatol. 2025. PMID: 39660667
OBJECTIVE: The objective of this study is to compare the efficacy and safety of lubiprostone (Lub) with osmotic laxatives in the treatment of chronic idiopathic constipation (CIC). ...According to the SUCRA results, the highest rank probabilities were for Lub in increasing …
OBJECTIVE: The objective of this study is to compare the efficacy and safety of lubiprostone (Lub) with osmotic laxatives in the trea …
Lubiprostone plus polyethylene glycol electrolyte lavage solution (PEG-ELS) versus PEG-ELS for bowel preparation in chronic constipation: a randomized controlled trial.
Tangvoraphonkchai K, Manasirisuk W, Sawadpanich K, Suttichaimongkol T, Mairiang P. Tangvoraphonkchai K, et al. Sci Rep. 2023 Sep 27;13(1):16265. doi: 10.1038/s41598-023-43598-6. Sci Rep. 2023. PMID: 37759079 Free PMC article. Clinical Trial.
The rate of adequate bowel cleansing was comparable between the PEG-ELS plus lubiprostone group and the PEG-ELS alone group (50% vs. 52.9%, p value = 0.81) with a relative risk of 1.13 (95% CI = 0.43-2.91). ...No additional benefit to successful bowel preparation was achie …
The rate of adequate bowel cleansing was comparable between the PEG-ELS plus lubiprostone group and the PEG-ELS alone group (50% vs. …
Effects of Lubiprostone, an Intestinal Secretagogue, on Electrolyte Homeostasis in Chronic Idiopathic and Opioid-induced Constipation.
Rao SSC, Lichtlen P, Habibi S. Rao SSC, et al. J Clin Gastroenterol. 2021 Jul 1;55(6):512-519. doi: 10.1097/MCG.0000000000001385. J Clin Gastroenterol. 2021. PMID: 32569031 Free PMC article. Clinical Trial.
We investigated short-term and long-term effects of lubiprostone on electrolyte, blood urea nitrogen (BUN), and creatinine levels using pooled data from CIC and OIC patients. ...In the double-blind, placebo-controlled studies, there were no clinically meaningful difference …
We investigated short-term and long-term effects of lubiprostone on electrolyte, blood urea nitrogen (BUN), and creatinine levels usi …
59 results