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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
1994 1
1995 2
1996 2
1997 3
1998 2
1999 1
2000 4
2001 14
2002 15
2003 13
2004 15
2005 19
2006 26
2007 31
2008 28
2009 18
2010 27
2011 24
2012 36
2013 41
2014 37
2015 36
2016 30
2017 37
2018 19
2019 15
2020 23
2021 9
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478 results
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Lutein and Zeaxanthin-Food Sources, Bioavailability and Dietary Variety in Age-Related Macular Degeneration Protection.
Eisenhauer B, Natoli S, Liew G, Flood VM. Eisenhauer B, et al. Nutrients. 2017 Feb 9;9(2):120. doi: 10.3390/nu9020120. Nutrients. 2017. PMID: 28208784 Free PMC article. Review.
Lutein and zeaxanthin (L/Z) are the predominant carotenoids which accumulate in the retina of the eye. The impact of L/Z intake on the risk and progression of age-related macular degeneration (AMD), a leading cause of blindness in the developed world,
Lutein and zeaxanthin (L/Z) are the predominant carotenoids which accumulate in the retina of the eye. The impact of L/Z intak
Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial.
Age-Related Eye Disease Study 2 Research Group. Age-Related Eye Disease Study 2 Research Group. JAMA. 2013 May 15;309(19):2005-15. doi: 10.1001/jama.2013.4997. JAMA. 2013. PMID: 23644932 Clinical Trial.
Kaplan-Meier probabilities of progression to advanced AMD by 5 years were 31% (493 eyes [406 participants]) for placebo, 29% (468 eyes [399 participants]) for lutein + zeaxanthin, 31% (507 eyes [416 participants]) for DHA + EPA, and 30% (472 eyes [387 participants]) …
Kaplan-Meier probabilities of progression to advanced AMD by 5 years were 31% (493 eyes [406 participants]) for placebo, 29% (468 eyes [399 …
Lutein, Zeaxanthin and Meso-zeaxanthin Supplementation Associated with Macular Pigment Optical Density.
Ma L, Liu R, Du JH, Liu T, Wu SS, Liu XH. Ma L, et al. Nutrients. 2016 Jul 12;8(7):426. doi: 10.3390/nu8070426. Nutrients. 2016. PMID: 27420092 Free PMC article. Review.
The purpose of this study was to evaluate the effects of lutein, zeaxanthin and meso-zeaxanthin on macular pigment optical density (MPOD) in randomized controlled trials (RCTs) among patients with age-related macular degeneration (AMD) an …
The purpose of this study was to evaluate the effects of lutein, zeaxanthin and meso-zeaxanthin on macular pigme …
Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression: AREDS2 report No. 3.
Age-Related Eye Disease Study 2 (AREDS2) Research Group, Chew EY, Clemons TE, Sangiovanni JP, Danis RP, Ferris FL 3rd, Elman MJ, Antoszyk AN, Ruby AJ, Orth D, Bressler SB, Fish GE, Hubbard GB, Klein ML, Chandra SR, Blodi BA, Domalpally A, Friberg T, Wong WT, Rosenfeld PJ, Agrón E, Toth CA, Bernstein PS, Sperduto RD. Age-Related Eye Disease Study 2 (AREDS2) Research Group, et al. JAMA Ophthalmol. 2014 Feb;132(2):142-9. doi: 10.1001/jamaophthalmol.2013.7376. JAMA Ophthalmol. 2014. PMID: 24310343 Free PMC article. Clinical Trial.
The Age-Related Eye Disease Study 2 (AREDS2) assessed the value of substituting lutein/zeaxanthin in the AREDS formulation because of the demonstrated risk for lung cancer from beta carotene in smokers and former smokers and because lutein and zeaxanthin
The Age-Related Eye Disease Study 2 (AREDS2) assessed the value of substituting lutein/zeaxanthin in the AREDS formulation bec …
Lutein and Zeaxanthin Isomers in Eye Health and Disease.
Mares J. Mares J. Annu Rev Nutr. 2016 Jul 17;36:571-602. doi: 10.1146/annurev-nutr-071715-051110. Annu Rev Nutr. 2016. PMID: 27431371 Free PMC article. Review.
Additionally, egg yolks and human milk appear to be bioavailable sources. The prevalence of lutein, zeaxanthin, and meso-zeaxanthin in supplements is increasing. ...Accumulating evidence about variable interindividual response to dietary intake of these carot …
Additionally, egg yolks and human milk appear to be bioavailable sources. The prevalence of lutein, zeaxanthin, and meso-ze
Dietary sources of lutein and zeaxanthin carotenoids and their role in eye health.
Abdel-Aal el-SM, Akhtar H, Zaheer K, Ali R. Abdel-Aal el-SM, et al. Nutrients. 2013 Apr 9;5(4):1169-85. doi: 10.3390/nu5041169. Nutrients. 2013. PMID: 23571649 Free PMC article. Review.
The eye is a major sensory organ that requires special care for a healthy and productive lifestyle. Numerous studies have identified lutein and zeaxanthin to be essential components for eye health. Lutein and zeaxanthin are carotenoid pigments that imp …
The eye is a major sensory organ that requires special care for a healthy and productive lifestyle. Numerous studies have identified lute
Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease.
Bernstein PS, Li B, Vachali PP, Gorusupudi A, Shyam R, Henriksen BS, Nolan JM. Bernstein PS, et al. Prog Retin Eye Res. 2016 Jan;50:34-66. doi: 10.1016/j.preteyeres.2015.10.003. Epub 2015 Nov 2. Prog Retin Eye Res. 2016. PMID: 26541886 Free PMC article. Review.
The human macula uniquely concentrates three carotenoids: lutein, zeaxanthin, and meso-zeaxanthin. Lutein and zeaxanthin must be obtained from dietary sources such as green leafy vegetables and orange and yellow fruits and vegetables, while meso …
The human macula uniquely concentrates three carotenoids: lutein, zeaxanthin, and meso-zeaxanthin. Lutein and …
No CFH or ARMS2 Interaction with Omega-3 Fatty Acids, Low versus High Zinc, or beta-Carotene versus Lutein and Zeaxanthin on Progression of Age-Related Macular Degeneration in the Age-Related Eye Disease Study 2: Age-Related Eye Disease Study 2 Report No. 18.
van Asten F, Chiu CY, Agrón E, Clemons TE, Ratnapriya R, Swaroop A, Klein ML, Fan R, Chew EY; Age-Related Eye Disease Study 2 Research Group. van Asten F, et al. Ophthalmology. 2019 Nov;126(11):1541-1548. doi: 10.1016/j.ophtha.2019.06.004. Epub 2019 Jun 12. Ophthalmology. 2019. PMID: 31358387 Free PMC article. Clinical Trial.
METHODS: AREDS2 participants (n = 4203) with bilateral large drusen or late AMD in 1 eye were assigned randomly to lutein and zeaxanthin, omega-3 fatty acids, both, or placebo, and most also received the AREDS supplements. ...The main treatment effects, as well as t …
METHODS: AREDS2 participants (n = 4203) with bilateral large drusen or late AMD in 1 eye were assigned randomly to lutein and zeax
Zeaxanthin and Lutein: Photoprotectors, Anti-Inflammatories, and Brain Food.
Demmig-Adams B, López-Pozo M, Stewart JJ, Adams WW 3rd. Demmig-Adams B, et al. Molecules. 2020 Aug 8;25(16):3607. doi: 10.3390/molecules25163607. Molecules. 2020. PMID: 32784397 Free PMC article. Review.
This review compares and contrasts the role of carotenoids across the taxa of life-with a focus on the xanthophyll zeaxanthin (and its structural isomer lutein) in plants and humans. Xanthophylls' multiple protective roles are summarized, with attention to the simil …
This review compares and contrasts the role of carotenoids across the taxa of life-with a focus on the xanthophyll zeaxanthin (and it …
Effect of Dietary Supplementation With Lutein, Zeaxanthin, and omega-3 on Macular Pigment: A Randomized Clinical Trial.
Korobelnik JF, Rougier MB, Delyfer MN, Bron A, Merle BMJ, Savel H, Chêne G, Delcourt C, Creuzot-Garcher C. Korobelnik JF, et al. JAMA Ophthalmol. 2017 Nov 1;135(11):1259-1266. doi: 10.1001/jamaophthalmol.2017.3398. JAMA Ophthalmol. 2017. PMID: 28973076 Free PMC article. Clinical Trial.
IMPORTANCE: Nutritional uptake of lutein, zeaxanthin, and omega-3 polyunsaturated fatty acids may increase macular pigment optical density (MPOD) and thereby protect against the development of age-related macular degeneration (AMD). OBJECTIVES: …
IMPORTANCE: Nutritional uptake of lutein, zeaxanthin, and omega-3 polyunsaturated fatty acids may increase macular pigm …
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