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13,215 results

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Page 1
What Are 3' UTRs Doing?
Mayr C. Mayr C. Cold Spring Harb Perspect Biol. 2019 Oct 1;11(10):a034728. doi: 10.1101/cshperspect.a034728. Cold Spring Harb Perspect Biol. 2019. PMID: 30181377 Free PMC article. Review.
3' untranslated regions (3' UTRs) of messenger RNAs (mRNAs) are best known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and translation. ...This review summarizes both 3' UTR fun …
3' untranslated regions (3' UTRs) of messenger RNAs (mRNAs) are best known to regulate mRNA-based …
Widespread 3'UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites.
Haberman N, Digby H, Faraway R, Cheung R, Chakrabarti AM, Jobbins AM, Parr C, Yasuzawa K, Kasukawa T, Yip CW, Kato M, Takahashi H, Carninci P, Vernia S, Ule J, Sibley CR, Martinez-Sanchez A, Lenhard B. Haberman N, et al. BMC Biol. 2024 Nov 7;22(1):254. doi: 10.1186/s12915-024-02032-7. BMC Biol. 2024. PMID: 39511645 Free PMC article.
The 3' untranslated region (3'UTR) plays a crucial role in determining mRNA stability, localisation, translation and degradation. ...By using a combination of AGO2 enhanced individual nucleotide resolution UV crosslinking and immunoprecipitation …
The 3' untranslated region (3'UTR) plays a crucial role in determining mRNA stability, localisation, tran …
Comparative Analysis of Published Database Predicting MicroRNA Binding in 3'UTR of mRNA in Diverse Species.
Ahirwar SS, Rizwan R, Sethi S, Shahid Z, Malviya S, Khandia R, Agarwal A, Kotnis A. Ahirwar SS, et al. Microrna. 2024;13(1):2-13. doi: 10.2174/0122115366261005231018070640. Microrna. 2024. PMID: 37929739 Review.
OBJECTIVE: This descriptive review aimed to analyse the usability of the existing database based on the following criteria: accessibility, efficiency, interpretability, updatability, and flexibility for miRNA target prediction of 3'UTR of mRNA in diverse spec …
OBJECTIVE: This descriptive review aimed to analyse the usability of the existing database based on the following criteria: accessibility, e …
Regulation of mRNA translation by 5'- and 3'-UTR-binding factors.
Wilkie GS, Dickson KS, Gray NK. Wilkie GS, et al. Trends Biochem Sci. 2003 Apr;28(4):182-8. doi: 10.1016/S0968-0004(03)00051-3. Trends Biochem Sci. 2003. PMID: 12713901 Review.
The past few years have seen a rapid expansion in the identification and characterization of mRNA regulatory elements and their binding proteins. For the majority of these examples, the mechanism by which translational regulation is achieved is not well understood. …
The past few years have seen a rapid expansion in the identification and characterization of mRNA regulatory elements and their bi …
Live cell imaging reveals 3'-UTR dependent mRNA sorting to synapses.
Bauer KE, Segura I, Gaspar I, Scheuss V, Illig C, Ammer G, Hutten S, Basyuk E, Fernández-Moya SM, Ehses J, Bertrand E, Kiebler MA. Bauer KE, et al. Nat Commun. 2019 Jul 18;10(1):3178. doi: 10.1038/s41467-019-11123-x. Nat Commun. 2019. PMID: 31320644 Free PMC article.
However, the precise process of mRNA sorting to synapses in neurons remains elusive. Here we use Rgs4 mRNA to investigate 3'-UTR-dependent transport by MS2 live-cell imaging. The majority of observed RNA granules display 3'-UTR ind …
However, the precise process of mRNA sorting to synapses in neurons remains elusive. Here we use Rgs4 mRNA to investigate 3 …
3'UTR of mRNA Encoding CPEB Protein Orb2 Plays an Essential Role in Intracellular Transport in Neurons.
Kozlov EN, Deev RV, Tokmatcheva EV, Tvorogova A, Kachaev ZM, Gilmutdinov RA, Zhukova M, Savvateeva-Popova EV, Schedl P, Shidlovskii YV. Kozlov EN, et al. Cells. 2023 Jun 25;12(13):1717. doi: 10.3390/cells12131717. Cells. 2023. PMID: 37443751 Free PMC article.
We found that the phenotypic effects of the orb2 3'UTR deletion were rescued by introducing the 3'UTR from the orb, another Drosophila CPEB gene. In contrast, the phenotypic effects of the 3'UTR deletion were not rescued by the 3' …
We found that the phenotypic effects of the orb2 3'UTR deletion were rescued by introducing the 3'UTR from the o …
Adipocyte RNA-binding protein CELF1 promotes beiging of white fat through stabilizing Dio2 mRNA.
Zeng T, Xiao L, Li J, Wu H, Guo X, Zhu F, Yu X, Cui Y, Zhao X, Wang Y, Zhang T, He W, Zeng H, Li X. Zeng T, et al. Nat Commun. 2025 Aug 11;16(1):7414. doi: 10.1038/s41467-025-62740-8. Nat Commun. 2025. PMID: 40789858 Free PMC article.
RNA-binding proteins (RBPs) regulate diverse post-transcriptional processes and play roles in adipocyte development; however, their role in white fat beiging remains unclear. ...Adipocyte-specific Celf1 deficiency impairs cold-induced thermogenic gene expression and …
RNA-binding proteins (RBPs) regulate diverse post-transcriptional processes and play roles in adipocyte development; however, …
Protein binding in an mRNA 5'-UTR sterically hinders translation.
Felder S, Nelson IM, Hatfield BM, Weeks KM. Felder S, et al. RNA. 2025 Jan 22;31(2):143-149. doi: 10.1261/rna.080136.124. RNA. 2025. PMID: 39662963 Free PMC article.
Binding of high-affinity proteins in the 5'-UTR hindered translation, whereas no effect was observed when the coat protein was targeted to the 3'-UTR. ...MS2 proteins engineered to bind two reporter mRNA sites had a stronger effect than those …
Binding of high-affinity proteins in the 5'-UTR hindered translation, whereas no effect was observed when the coat protein was …
Pumilio differentially binds to mRNA 3' UTR isoforms to regulate localization of synaptic proteins.
Grzejda D, Hess A, Rezansoff A, Gorey S, Carrasco J, Alfonso-Gonzalez C, Tsagkris S, Neuhaus L, Shi M, Ozbulut HC, Vögtle FN, Vlachos A, Hilgers V. Grzejda D, et al. EMBO Rep. 2025 Apr;26(7):1792-1815. doi: 10.1038/s44319-025-00401-z. Epub 2025 Feb 21. EMBO Rep. 2025. PMID: 39984683 Free PMC article.
In this study, we globally investigate the role of alternative 3' UTRs in regulating RNA localization in the synaptic regions of the Drosophila brain. ...Pumilio differentially binds to RNA isoforms of the same gene, favoring long, neuronal 3 …
In this study, we globally investigate the role of alternative 3' UTRs in regulating RNA localization in the synaptic regio …
Identification of 3' UTR motifs required for mRNA localization to myelin sheaths in vivo.
Yergert KM, Doll CA, O'Rouke R, Hines JH, Appel B. Yergert KM, et al. PLoS Biol. 2021 Jan 13;19(1):e3001053. doi: 10.1371/journal.pbio.3001053. eCollection 2021 Jan. PLoS Biol. 2021. PMID: 33439856 Free PMC article.
To investigate how mRNAs are targeted to myelin sheaths, we tested the hypothesis that transcripts are selected for myelin enrichment through consensus sequences in the 3' untranslated region (3' UTR). Using methods to visualize mRNA in living z …
To investigate how mRNAs are targeted to myelin sheaths, we tested the hypothesis that transcripts are selected for myelin enrichment throug …
13,215 results
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