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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
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1986 1
1987 10
1988 6
1989 6
1990 9
1991 8
1992 10
1993 18
1994 21
1995 17
1996 25
1997 23
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1999 29
2000 27
2001 44
2002 28
2003 42
2004 61
2005 47
2006 58
2007 53
2008 60
2009 64
2010 70
2011 64
2012 70
2013 60
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2015 49
2016 49
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1,448 results

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Page 1
The plant Cleavage Factor I complex is essential for precise cleavage and polyadenylation site determination.
Szewc L, Zhang X, Bajczyk M, Bielewicz D, Zimna M, Yura K, Kato M, Nomoto M, Garcia-León M, Rubio V, Tada Y, Furumoto T, Aoyama T, Szweykowska-Kulinska Z, Staiger D, Jarmolowski A, Tsuge T. Szewc L, et al. Plant Physiol. 2025 Oct 31;199(3):kiaf483. doi: 10.1093/plphys/kiaf483. Plant Physiol. 2025. PMID: 41066534
Cleavage Factor I (CFI) is a 4-subunit protein complex of the pre-mRNA 3' end processing machinery in eukaryotes. ...Moreover, these morphological defects correlated with alterations in the usage of 3' UTR cleavage and polyadenylation sites. atc …
Cleavage Factor I (CFI) is a 4-subunit protein complex of the pre-mRNA 3' end processing machinery in eukaryotes …
Mediator regulates transcriptional termination through crosstalk with pre-mRNA 3' end processing factors.
Lu C, Bai X, Zhang H, Zhang Y, Yang M, Zheng Y, Jin Z, Yang W, Guo G, Huang Q, Huang Y, Wu L, Fu XD, Zhang Z, Wang G. Lu C, et al. Mol Cell. 2025 Jun 5;85(11):2147-2164.e10. doi: 10.1016/j.molcel.2025.05.006. Epub 2025 May 28. Mol Cell. 2025. PMID: 40441154
Beyond its function in transcription initiation, the Mediator complex coordinates the processes of transcription elongation and mRNA splicing. Here, we report that Mediator associates with the cleavage and polyadenylation specificity factor (CPSF) c …
Beyond its function in transcription initiation, the Mediator complex coordinates the processes of transcription elongation and mR …
Pre-mRNA processing factors differentially impact coordination between co-transcriptional cleavage and transcription termination.
Jin X, Li J, Lu W, Deng X, Wei Y, Shu Y, Liu B, Liu Z, Long Y, Zhu X, Fei Q, Xia Y, Li QQ, Michaels SD, Cao X, Lenhard M, Zhai J. Jin X, et al. Nat Commun. 2025 Aug 1;16(1):7086. doi: 10.1038/s41467-025-62555-7. Nat Commun. 2025. PMID: 40750766 Free PMC article.
Here, we applied single-molecule nascent RNA sequencing to simultaneously capture the cleavage status and readthrough distance on the same nascent RNA molecules and characterize 14 mutants of various pre-mRNA processing factors in Arabidopsis. . …
Here, we applied single-molecule nascent RNA sequencing to simultaneously capture the cleavage status and readthrough distance …
Activation of the Endonuclease that Defines mRNA 3' Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex.
Hill CH, Boreikaitė V, Kumar A, Casañal A, Kubík P, Degliesposti G, Maslen S, Mariani A, von Loeffelholz O, Girbig M, Skehel M, Passmore LA. Hill CH, et al. Mol Cell. 2019 Mar 21;73(6):1217-1231.e11. doi: 10.1016/j.molcel.2018.12.023. Epub 2019 Feb 5. Mol Cell. 2019. PMID: 30737185 Free PMC article.
Cleavage and polyadenylation factor (CPF/CPSF) is a multi-protein complex essential for formation of eukaryotic mRNA 3' ends. ...Cleavage also requires the accessory cleavage factors IA and IB, which bind substrate pre-mRNAs and CP …
Cleavage and polyadenylation factor (CPF/CPSF) is a multi-protein complex essential for formation of eukaryotic mRNA …
Surveillance of 3' mRNA cleavage during transcription termination requires CF IB/Hrp1.
Li J, Querl L, Coban I, Salinas G, Krebber H. Li J, et al. Nucleic Acids Res. 2023 Sep 8;51(16):8758-8773. doi: 10.1093/nar/gkad530. Nucleic Acids Res. 2023. PMID: 37351636 Free PMC article.
CF IB/Hrp1 is part of the cleavage and polyadenylation factor (CPF) and cleavage factor (CF) complex (CPF-CF), which is responsible for 3' cleavage and maturation of pre-mRNAs. Although Hrp1 supports this process, its presence is not esse …
CF IB/Hrp1 is part of the cleavage and polyadenylation factor (CPF) and cleavage factor (CF) complex (CPF …
Regulation of the hypertonic stress response by the 3' mRNA cleavage and polyadenylation complex.
Urso SJ, Sathaseevan A, Brent Derry W, Lamitina T. Urso SJ, et al. Genetics. 2023 May 4;224(1):iyad051. doi: 10.1093/genetics/iyad051. Genetics. 2023. PMID: 36972377 Free PMC article.
Both cpf-2 and symk-1 are nuclear components of the highly conserved 3' mRNA cleavage and polyadenylation complex. cpf-2 and symk-1 block the hypertonic induction of gpdh-1 and other osmotically induced mRNAs, suggesting they act at the transcriptional level. …
Both cpf-2 and symk-1 are nuclear components of the highly conserved 3' mRNA cleavage and polyadenylation complex. cpf- …
Regulation of the Ysh1 endonuclease of the mRNA cleavage/polyadenylation complex by ubiquitin-mediated degradation.
Lee SD, Liu HY, Graber JH, Heller-Trulli D, Kaczmarek Michaels K, Cerezo JF, Moore CL. Lee SD, et al. RNA Biol. 2020 May;17(5):689-702. doi: 10.1080/15476286.2020.1724717. Epub 2020 Feb 12. RNA Biol. 2020. PMID: 32009536 Free PMC article.
Mutation of the essential yeast protein Ipa1 has previously been demonstrated to cause defects in pre-mRNA 3' end processing and growth, but the mechanism underlying these defects was not clear. In this study, we show that the ipa1-1 mutation causes a striking depletion of …
Mutation of the essential yeast protein Ipa1 has previously been demonstrated to cause defects in pre-mRNA 3' end processing and grow …
A Complex of U1 snRNP with Cleavage and Polyadenylation Factors Controls Telescripting, Regulating mRNA Transcription in Human Cells.
So BR, Di C, Cai Z, Venters CC, Guo J, Oh JM, Arai C, Dreyfuss G. So BR, et al. Mol Cell. 2019 Nov 21;76(4):590-599.e4. doi: 10.1016/j.molcel.2019.08.007. Epub 2019 Sep 12. Mol Cell. 2019. PMID: 31522989 Free PMC article.
However, the mechanism of this U1 activity, termed telescripting, is unknown. Here, we captured a complex, comprising U1 and CPA factors (U1-CPAFs), that binds intronic PASs and suppresses PCPA. U1-CPAFs are distinct from U1-spliceosomal complexes; they inclu …
However, the mechanism of this U1 activity, termed telescripting, is unknown. Here, we captured a complex, comprising U1 and CPA f …
Two mechanisms repress cyclin B1 translation to maintain prophase arrest in mouse oocytes.
Cheng S, Schuh M. Cheng S, et al. Nat Commun. 2024 Nov 20;15(1):10044. doi: 10.1038/s41467-024-54161-w. Nat Commun. 2024. PMID: 39567493 Free PMC article.
Using Trim-Away, we identify two mechanisms that maintain cyclin B1 dormancy and thus prophase arrest. First, a complex of the RNA-binding proteins DDX6, LSM14B and CPEB1 directly represses cyclin B1 translation through interacting with its 3'UTR. Second, cytoplasmi …
Using Trim-Away, we identify two mechanisms that maintain cyclin B1 dormancy and thus prophase arrest. First, a complex of the RNA …
A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA)(n) Repeats Associated with Friedreich's Ataxia.
McGinty RJ, Puleo F, Aksenova AY, Hisey JA, Shishkin AA, Pearson EL, Wang ET, Housman DE, Moore C, Mirkin SM. McGinty RJ, et al. Cell Rep. 2017 Sep 5;20(10):2490-2500. doi: 10.1016/j.celrep.2017.08.051. Cell Rep. 2017. PMID: 28877480 Free PMC article.
Using this method, we found that missense mutations in the endoribonuclease subunit (Ysh1) of the mRNA cleavage and polyadenylation complex dramatically increase the rate of (GAA)(n) repeat expansions but only when they are actively transcribed. ...These resu …
Using this method, we found that missense mutations in the endoribonuclease subunit (Ysh1) of the mRNA cleavage and polyadenyl …
1,448 results