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506 results

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Page 1
Did you mean mRNA splicing, via pliceosome (6,331 results)?
A day in the life of the spliceosome.
Matera AG, Wang Z. Matera AG, et al. Nat Rev Mol Cell Biol. 2014 Feb;15(2):108-21. doi: 10.1038/nrm3742. Nat Rev Mol Cell Biol. 2014. PMID: 24452469 Free PMC article. Review.
The subsequent realization that the intervening regions are removed from pre-mRNA transcripts via the activity of a common set of small nuclear RNAs (snRNAs), which assemble together with associated proteins into a complex known as the spliceosome, was equall …
The subsequent realization that the intervening regions are removed from pre-mRNA transcripts via the activity of a common set …
USP42 drives nuclear speckle mRNA splicing via directing dynamic phase separation to promote tumorigenesis.
Liu S, Wang T, Shi Y, Bai L, Wang S, Guo D, Zhang Y, Qi Y, Chen C, Zhang J, Zhang Y, Liu Q, Yang Q, Wang Y, Liu H. Liu S, et al. Cell Death Differ. 2021 Aug;28(8):2482-2498. doi: 10.1038/s41418-021-00763-6. Epub 2021 Mar 17. Cell Death Differ. 2021. PMID: 33731873 Free PMC article.
Functionally, USP42 downregulation deregulates multiple mRNA splicing events and leads to deterred cancer cell growth, which is consistent with the impact of PLRG1 repression. ...As a deubiquitylase capable of dynamically guiding nuclear speckle phase separation and …
Functionally, USP42 downregulation deregulates multiple mRNA splicing events and leads to deterred cancer cell growth, which i …
Mechanisms and regulation of spliceosome-mediated pre-mRNA splicing in Saccharomyces cerevisiae.
Senn KA, Hoskins AA. Senn KA, et al. Wiley Interdiscip Rev RNA. 2024 Jul-Aug;15(4):e1866. doi: 10.1002/wrna.1866. Wiley Interdiscip Rev RNA. 2024. PMID: 38972853 Free PMC article. Review.
Pre-mRNA splicing, the removal of introns and ligation of flanking exons, is a crucial step in eukaryotic gene expression. ...This article is categorized under: RNA Processing > Splicing Mechanisms RNA Processing > Splicing Regulati …
Pre-mRNA splicing, the removal of introns and ligation of flanking exons, is a crucial step in eukaryotic gene expression. ... …
RBM25 is required to restrain inflammation via ACLY RNA splicing-dependent metabolism rewiring.
Zhang Y, Gao Y, Wang Y, Jiang Y, Xiang Y, Wang X, Wang Z, Ding Y, Chen H, Rui B, Huai W, Cai B, Ren X, Ma F, Xu S, Zhan Z, Liu X. Zhang Y, et al. Cell Mol Immunol. 2024 Nov;21(11):1231-1250. doi: 10.1038/s41423-024-01212-3. Epub 2024 Sep 9. Cell Mol Immunol. 2024. PMID: 39251781 Free PMC article.
Spliceosome dysfunction and aberrant RNA splicing underline unresolved inflammation and immunopathogenesis. Here, we revealed the misregulation of mRNA splicing via the spliceosome in the pathogenesis of rheumatoid arthritis (RA). …
Spliceosome dysfunction and aberrant RNA splicing underline unresolved inflammation and immunopathogenesis. Here, we re …
CDK7-CDK11 axis in spliceosome regulation and pre-mRNA splicing.
Rájecký M, Gajdušková P, Maník P, Hluchý M, Hegedűsová E, Kryštofová K, Potěšil D, Martinková P, Slabá Z, Khirsariya P, Šebesta M, Paruch K, Friedel CC, Zdráhal Z, Blazek D. Rájecký M, et al. Nucleic Acids Res. 2025 Nov 26;53(22):gkaf1343. doi: 10.1093/nar/gkaf1343. Nucleic Acids Res. 2025. PMID: 41428738 Free PMC article.
Cyclin-dependent kinase 11 (CDK11) is essential for the regulation of pre-mRNA splicing via phosphorylation of the core spliceosome component SF3B1. This phosphorylation is a marker of the catalytically active spliceosomes; thus, it is important …
Cyclin-dependent kinase 11 (CDK11) is essential for the regulation of pre-mRNA splicing via phosphorylation of the core …
CCAR1 promotes DNA repair via alternative splicing.
Karasu ME, Jahnke L, Joseph BJ, Amerzhanova Y, Mironov A, Shu X, Schröder MS, Gvozdenovic A, Sala I, Zavolan M, Jonas S, Corn JE. Karasu ME, et al. Mol Cell. 2024 Jul 25;84(14):2634-2647.e9. doi: 10.1016/j.molcel.2024.06.011. Epub 2024 Jul 3. Mol Cell. 2024. PMID: 38964321 Free article.
Transcriptomic analysis revealed that the CCAR1 splicing modulatory activity is not limited to FANCA, and it instead regulates widespread changes in alternative splicing that would damage coding sequences in mouse and human cells. CCAR1 therefore has an unanticipate …
Transcriptomic analysis revealed that the CCAR1 splicing modulatory activity is not limited to FANCA, and it instead regulates widesp …
SF3B3-regulated mTOR alternative splicing promotes colorectal cancer progression and metastasis.
Xu T, Li X, Zhao W, Wang X, Jin L, Feng Z, Li H, Zhang M, Tian Y, Hu G, Yue Y, Dai X, Shan C, Zhang W, Zhang C, Zhang Y. Xu T, et al. J Exp Clin Cancer Res. 2024 Apr 26;43(1):126. doi: 10.1186/s13046-024-03053-4. J Exp Clin Cancer Res. 2024. PMID: 38671459 Free PMC article.
BACKGROUND: Aberrant alternative splicing (AS) is a pervasive event during colorectal cancer (CRC) development. SF3B3 is a splicing factor component of U2 small nuclear ribonucleoproteins which are crucial for early stages of spliceosome assembly. ...Mechanis …
BACKGROUND: Aberrant alternative splicing (AS) is a pervasive event during colorectal cancer (CRC) development. SF3B3 is a splicin …
Lights, camera, action! Capturing the spliceosome and pre-mRNA splicing with single-molecule fluorescence microscopy.
DeHaven AC, Norden IS, Hoskins AA. DeHaven AC, et al. Wiley Interdiscip Rev RNA. 2016 Sep;7(5):683-701. doi: 10.1002/wrna.1358. Epub 2016 May 20. Wiley Interdiscip Rev RNA. 2016. PMID: 27198613 Free PMC article. Review.
The process of removing intronic sequences from a precursor to messenger RNA (pre-mRNA) to yield a mature mRNA transcript via splicing is an integral step in eukaryotic gene expression. Splicing is carried out by a cellular nanomachine ca …
The process of removing intronic sequences from a precursor to messenger RNA (pre-mRNA) to yield a mature mRNA transcri …
Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia.
Jin P, Wang X, Jin Q, Zhang Y, Shen J, Jiang G, Zhu H, Zhao M, Wang D, Li Z, Zhou Y, Li W, Zhang W, Liu Y, Wang S, Jin W, Cao Y, Sheng G, Dong F, Wu S, Li X, Jin Z, He M, Liu X, Chen L, Zhang Y, Wang K, Li J. Jin P, et al. Cancer Res. 2024 May 15;84(10):1583-1596. doi: 10.1158/0008-5472.CAN-23-2543. Cancer Res. 2024. PMID: 38417135
Herein, we retrospectively analyzed the multiomics data of more than 1,500 AML cases and found that patients with spliceosome mutations had a higher risk of developing refractory disease. RNA splicing analysis revealed that the mis-spliced genes in refractory …
Herein, we retrospectively analyzed the multiomics data of more than 1,500 AML cases and found that patients with spliceosome mutatio …
Best practice standards for circular RNA research.
Nielsen AF, Bindereif A, Bozzoni I, Hanan M, Hansen TB, Irimia M, Kadener S, Kristensen LS, Legnini I, Morlando M, Jarlstad Olesen MT, Pasterkamp RJ, Preibisch S, Rajewsky N, Suenkel C, Kjems J. Nielsen AF, et al. Nat Methods. 2022 Oct;19(10):1208-1220. doi: 10.1038/s41592-022-01487-2. Epub 2022 May 26. Nat Methods. 2022. PMID: 35618955 Free PMC article. Review.
Circular RNAs (circRNAs) are formed in all domains of life and via different mechanisms. There has been an explosion in the number of circRNA papers in recent years; however, as a relatively young field, circRNA biology has an urgent need for common experimental standards …
Circular RNAs (circRNAs) are formed in all domains of life and via different mechanisms. There has been an explosion in the number of …
506 results