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4,752 results

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Page 1
Molecular Mechanisms of Macroautophagy, Microautophagy, and Chaperone-Mediated Autophagy.
Yamamoto H, Matsui T. Yamamoto H, et al. J Nippon Med Sch. 2024 Mar 9;91(1):2-9. doi: 10.1272/jnms.JNMS.2024_91-102. Epub 2023 Jun 2. J Nippon Med Sch. 2024. PMID: 37271546 Free article. Review.
Autophagy can be classified into three categories: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). Macroautophagy involves membrane elongation and microautophagy involves membrane internalization, and both pathways undergo selective or non-se …
Autophagy can be classified into three categories: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). Macroau …
Macroautophagy in CNS health and disease.
Griffey CJ, Yamamoto A. Griffey CJ, et al. Nat Rev Neurosci. 2022 Jul;23(7):411-427. doi: 10.1038/s41583-022-00588-3. Epub 2022 May 3. Nat Rev Neurosci. 2022. PMID: 35505254 Free PMC article. Review.
Macroautophagy is an evolutionarily conserved process that delivers diverse cellular contents to lysosomes for degradation. ...Macroautophagy is a broadly used homeostatic process, giving rise to questions surrounding how defects in this single pathway could cause d …
Macroautophagy is an evolutionarily conserved process that delivers diverse cellular contents to lysosomes for degradation. ...Mac …
Macroautophagy at the service of synapses.
Wosnitzka E, Gambarotto L, Nikoletopoulou V. Wosnitzka E, et al. Curr Opin Neurobiol. 2025 Aug;93:103054. doi: 10.1016/j.conb.2025.103054. Epub 2025 May 24. Curr Opin Neurobiol. 2025. PMID: 40414166 Free article. Review.
Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage.
Murley A, Popovici AC, Hu XS, Lund A, Wickham K, Durieux J, Joe L, Koronyo E, Zhang H, Genuth NR, Dillin A. Murley A, et al. Cell. 2025 May 15;188(10):2670-2686.e14. doi: 10.1016/j.cell.2025.03.009. Epub 2025 Apr 8. Cell. 2025. PMID: 40203825 Free article.
Protein aggregates are also targeted to lysosomes by macroautophagy in quiescent cultured mammalian cells and are associated with lysosome damage. Thus, lysosome damage is a hallmark of quiescent cells, and limiting lysosome damage by restraining macroautophagy can …
Protein aggregates are also targeted to lysosomes by macroautophagy in quiescent cultured mammalian cells and are associated with lys …
Macroautophagy in quiescent and senescent cells: a pathway to longevity?
Murley A, Dillin A. Murley A, et al. Trends Cell Biol. 2023 Jun;33(6):495-504. doi: 10.1016/j.tcb.2022.10.004. Epub 2022 Nov 20. Trends Cell Biol. 2023. PMID: 36414491 Review.
Findings also point to both pro-senescence and anti-senescence functions for macroautophagy depending on context. In this review, we will discuss these findings, unanswered questions on the role of macroautophagy and lysosomal function in quiescent and senescent cel …
Findings also point to both pro-senescence and anti-senescence functions for macroautophagy depending on context. In this review, we …
Impaired neuronal macroautophagy in the prelimbic cortex contributes to comorbid anxiety-like behaviors in rats with chronic neuropathic pain.
Fu S, Sun H, Wang J, Gao S, Zhu L, Cui K, Liu S, Qi X, Guan R, Fan X, Liu Q, Chen W, Su L, Cui S, Liao F, Liu F, Wong CCL, Yi M, Wan Y. Fu S, et al. Autophagy. 2024 Jul;20(7):1559-1576. doi: 10.1080/15548627.2024.2330038. Epub 2024 Mar 24. Autophagy. 2024. PMID: 38522078 Free PMC article.
Intriguingly, such macroautophagy impairment was mainly observed in a FOS/c-Fos(+) neuronal subpopulation in the PrL. ...By contrast, artificial disruption of macroautophagy induced early-onset co-morbid anxiety in neuropathic rats, but not general anxiety in normal …
Intriguingly, such macroautophagy impairment was mainly observed in a FOS/c-Fos(+) neuronal subpopulation in the PrL. ...By contrast, …
Deacetylation of ATG7 drives the induction of macroautophagy and LC3-associated microautophagy.
Xu Y, Qian C, Wang Q, Song L, He Z, Liu W, Wan W. Xu Y, et al. Autophagy. 2024 May;20(5):1134-1146. doi: 10.1080/15548627.2023.2287932. Epub 2023 Nov 28. Autophagy. 2024. PMID: 37999993 Free PMC article.
LC3 lipidation plays an important role in the regulation of macroautophagy and LC3-associated microautophagy. The E1-like enzyme ATG7 is one of the core components that are directly involved in LC3 lipidation reaction. ...Functionally, in response to various different stim …
LC3 lipidation plays an important role in the regulation of macroautophagy and LC3-associated microautophagy. The E1-like enzyme ATG7 …
Macroautophagy is repressed during mitosis - seeing is believing.
Odle RI, Cook SJ. Odle RI, et al. Autophagy. 2020 Apr;16(4):775-776. doi: 10.1080/15548627.2020.1725405. Epub 2020 Feb 20. Autophagy. 2020. PMID: 32079445 Free PMC article. Review.
For the last two decades there has been wide ranging debate about the status of macroautophagy during mitosis. Because metazoan cells undergo an "open" mitosis in which the nuclear envelope breaks down, it has been proposed that macroautophagy must be inhibited to m …
For the last two decades there has been wide ranging debate about the status of macroautophagy during mitosis. Because metazoan cells …
Alternative macroautophagy and mitophagy.
Shimizu S, Honda S, Arakawa S, Yamaguchi H. Shimizu S, et al. Int J Biochem Cell Biol. 2014 May;50:64-6. doi: 10.1016/j.biocel.2014.02.016. Epub 2014 Feb 22. Int J Biochem Cell Biol. 2014. PMID: 24569119 Review.
Mitophagy is a mitochondrial quality control mechanism where damaged and surplus mitochondria are removed by macroautophagy. Mitophagy is associated with various physiological and pathological events such as mitochondrial clearance during terminal differentiation of reticu …
Mitophagy is a mitochondrial quality control mechanism where damaged and surplus mitochondria are removed by macroautophagy. Mitophag …
Role of Macroautophagy in Mammalian Male Reproductive Physiology.
Kirat D, Alahwany AM, Arisha AH, Abdelkhalek A, Miyasho T. Kirat D, et al. Cells. 2023 May 5;12(9):1322. doi: 10.3390/cells12091322. Cells. 2023. PMID: 37174722 Free PMC article. Review.
Non-selective macroautophagy randomly engulfs the cytoplasmic components in autophagosomes that are degraded by lysosomal enzymes. While selective macroautophagy precisely identifies and degrades a specific element, current findings have shown the novel functional r …
Non-selective macroautophagy randomly engulfs the cytoplasmic components in autophagosomes that are degraded by lysosomal enzymes. Wh …
4,752 results