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Blockage of autophagy causes severe skeletal muscle disruption in a mouse model for myofibrillar myopathy 6.
Filippi K, Graf-Riesen K, Kuppusamy M, Unger A, Kimura K, Matijass M, Baeta H, Podlacha M, Haertter D, Kudin AP, Wiemann M, Węgrzyn G, Kornblum C, Reimann J, Linke WA, Huesgen PF, Kunz WS, Fleischmann BK, Hesse M. Filippi K, et al. Among authors: kuppusamy m. Nat Commun. 2026 Apr 11;17(1):3436. doi: 10.1038/s41467-026-71749-6. Nat Commun. 2026. PMID: 41965903 Free PMC article.
Rejuvenation of the Aged Cerebrovascular System via Protein Corona-Guided Fusogenic Liposome Delivery.
Shanmugarama S, Gronemann T, Csik B, Patai R, Nyúl-Tóth Á, Nagy D, Hricisak L, Nagykaldi M, Sanford M, Nagaraja RY, Gulej R, Kristof R, Kordestan KV, Brunner EG, Negri S, Abushukair H, Jung W, Tarantini S, Chandragiri SS, Sirpal P, Conley S, Mukli P, Yabluchanskiy A, Mukherjee P, Berkamp S, Hersch N, Kuppusamy M, Sachse C, Huesgen P, Merkel R, Kiss T, Benyo Z, Oh TG, Ungvari Z, Csiszar A, Csiszar A. Shanmugarama S, et al. Among authors: kuppusamy m. bioRxiv [Preprint]. 2026 Mar 9:2026.03.05.709925. doi: 10.64898/2026.03.05.709925. bioRxiv. 2026. PMID: 41959031 Free PMC article. Preprint.
Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy.
Frank D, Patnana PK, Vorwerk J, Mao L, Gopal LM, Jung N, Hennig T, Ruhnke L, Frenz JM, Kuppusamy M, Autry R, Wei L, Sun K, Mohammed Ahmed HM, Künstner A, Busch H, Müller H, Hutter S, Hoermann G, Liu L, Xie X, Al-Matary Y, Nimmagadda SC, Cano FC, Heuser M, Thol F, Göhring G, Steinemann D, Thomale J, Leitner T, Fischer A, Rad R, Röllig C, Altmann H, Kunadt D, Berdel WE, Hüve J, Neumann F, Klingauf J, Calderon V, Opalka B, Dührsen U, Rosenbauer F, Dugas M, Varghese J, Reinhardt HC, von Bubnoff N, Möröy T, Lenz G, Batcha AMN, Giorgi M, Selvam M, Wang E, McWeeney SK, Tyner JW, Stölzel F, Mann M, Jayavelu AK, Khandanpour C. Frank D, et al. Among authors: kuppusamy m. Blood. 2023 Dec 21;142(25):2175-2191. doi: 10.1182/blood.2022015752. Blood. 2023. PMID: 37756525 Free PMC article.
Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy.
Kimura K, Ooms A, Graf-Riesen K, Kuppusamy M, Unger A, Schuld J, Daerr J, Lother A, Geisen C, Hein L, Takahashi S, Li G, Röll W, Bloch W, van der Ven PFM, Linke WA, Wu SM, Huesgen PF, Höhfeld J, Fürst DO, Fleischmann BK, Hesse M. Kimura K, et al. Among authors: kuppusamy m. Nat Commun. 2021 Jun 11;12(1):3575. doi: 10.1038/s41467-021-23858-7. Nat Commun. 2021. PMID: 34117258 Free PMC article.