Getting to the heart of hERG K(+) channel gating.
J Physiol. 2015 Jun 15;593(12):2575-85. doi: 10.1113/JP270095.
J Physiol. 2015.
PMID: 25820318
Free PMC article.
Review.
First, they have very unusual gating kinetics, most notably rapid and voltage-dependent inactivation coupled to slow deactivation, which has led to the suggestion that they may play a specific role in the suppression of arrhythmias. Second, mutations in hERG are the cause …
First, they have very unusual gating kinetics, most notably rapid and voltage-dependent inactivation coupled to slow deactivation, which has …